CYTOCHROME

作品数：197被引量：480H指数：12
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Cytochrome P4503A gene family in gastric cancer:Unveiling diagnostic biomarkers and therapeutic targets for personalized treatment
《World Journal of Clinical Oncology》2025年第4期31-43,共13页Jun-Kun Zhu Jing Wang 
The cytochrome P4503A(CYP3A)gene family’s role in early progression of gastric cancer was comprehensively investigated.Its potential as a therapeutic target was evaluated.Upon literature review,aberrant expression of...
关键词：Gastric cancer Cytochrome P4503A Early diagnosis Therapeutic target Precision medicine 
Adding new dimension to non-directed C(sp^(3))-H functionalizations
《Science China Chemistry》2025年第4期1215-1217,共3页Konstantin P.Bryliakov 
Aliphatic C-H groups are among the most abundant yet least reactive functional groups in organic molecules.Nature has evolved metalloenzymes such as those of the cytochrome P450 superfamily that efficiently activate i...
关键词：complex molecules organic moleculesnature aliphatic c h groups METALLOENZYMES non directed c sp h functionalization synthetic applications cytochrome p cytochrome p superfamily 
Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model
《Research》2025年第1期618-630,共13页Qian Wang Xiaonan Liu Hejian Zhang Huanyu Chu Chao Shi Lei Zhang Jie Bai Pi Liu Jing Li Xiaoxi Zhu Yuwan Liu Zhangxin Chen Rong Huang Hong Chang Tian Liu Zhenzhan Chang Jian Cheng Huifeng Jiang 
funding from the National Key R&D Program of China(grant no.2019YFA0905700 and 2021YFC2103500);the National Natural Science Foundation of China(no.32371499);the China Postdoctoral Science Foundation(grant no.2019M661032);the National Natural Science Foundation of China(NSFC,grant nos.31901026 and 32171418);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(nos.TSBICIP-KJGG-002-02 and TSBICIP-CXRC-015);the Tianjin Science Fund for Distinguished Young Scholars(no.18JCJQJC48300).
Although cytochrome P450 enzymes are the most versatile biocatalysts in nature,there is insufficient comprehension of the molecular mechanism underlying their functional innovation process.Here,by combining ancestral ...
关键词：cytochrome P progressive forward accumulationwe cytochrome p enzymes molecular mechanism ancestral sequence reconstructionreverse mutation assayand de novo design catalytic pocket functional innovation 
Cytochrome P45026A1 Contributes to the Maintenance of Neuropathic Pain
《Neuroscience Bulletin》2024年第3期293-309,共17页De-Li Cao Ling-Jie Ma Bao-Chun Jiang Qiang Gu Yong-Jing Gao 
supported by STI2030-Major Projects(2022ZD0204700);the National Natural Science Foundation of China(32030048,31700899,and 32200817);the Graduate Student Scientific Research Innovation Projects of Jiangsu Province(KYCX18-2397);the Startup Foundation for Doctors of the Affiliated Hospital of Nantong University(Tdb1906).
The cytochrome P450 proteins(CYP450s)have been implicated in catalyzing numerous important biological reactions and contribute to a variety of diseases.CYP26A1,a member of the CYP450 family,carries out the oxidative m...
关键词：CYP26A1 MICROGLIA ASTROCYTES ERK P38 IL-10 Neuropathic pain 
Nitric oxide synthase-guided genome mining identifies a cytochrome P450 enzyme for olefin nitration in bacterial specialized metabolism
《Synthetic and Systems Biotechnology》2024年第1期127-133,共7页Hu Li Wei Li Kaihui Song Yu Liu Guiyun Zhao Yi-Ling Du 
supported by the National Natural Science Foundation of China(32122005 and 32370051)to Y.-L.D.
The biological signaling molecule nitric oxide(NO)has recently emerged as a metabolic precursor for the creation of microbial natural products with diversified structures and biological activities.Within the biosynthe...
关键词：Nitric oxide Genome mining BIOSYNTHESIS NITRATION CYTOCHROME P450 
A cytochrome c551 mediates the cyclic electron transport chain of the anoxygenic phototrophic bacterium Roseiflexus castenholzii被引量：1
《Plant Communications》2024年第2期79-93,共15页Lu Yu Zhenzhen Min Menghua Liu Yueyong Xin Aokun Liu Jian Kuang Wenping Wu Jingyi Wu Huimin He Jiyu Xin Robert EBlankenship Changlin Tian Xiaoling Xu 
supported by grants from the National Natural Science Foundation of China (32171227,31870740,and 31570738 to X.X.,21825703 and 21927814 to C.T.);the National Key Research and Development Project of China (2019YFA0405600 and 2019YFA0706900 to C.T.);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB37040000)to C.T.,;the Youth Innovation Promotion Association CAS (2022455)to L.Y.,;the Zhejiang Provincial Natural Science Foundation of China under grant LR22C020002 to X.X.
Roseiflexus castenholzii is a gram-negativefilamentous phototrophic bacterium that carries out anoxygenic photosynthesis through a cyclic electron transport chain(ETC).The ETC is composed of a reaction center(RC)–lig...
关键词：cytochrome c menaquinol oxidoreductase electron transport chain electron paramagnetic reso-nance light-harvesting complex 
Characterization of PetM cytochrome b6f subunit 7 domain-containing protein in tomato
《Horticulture Research》2023年第12期14-25,共12页Mustafa Bulut Adriano Nunes-Nesi Alisdair R.Fernie Saleh Alseekh 
We would like to thank Dr.Micha Wijesingha Ahchige for guiding and giving advice for the CRISPR/Cas9 vector generation and Dr.Mark A.Schoettler and Dr.Ryo Yokohama for the scientific advices and discussions.Also thanks to Dr.Karin Köhl,the greenhouse team of theMax Planck Institute of Molecular Plant Physiology,for transforming and handling the plants.M.B.appreciates the finan-cial support of the International Max Planck Research School for Molecular Plant Sciences(IMPRS-MolPlant).The research fellow-ship granted by Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq-Brazil)to A.N.-N.is gratefully acknowledged.A.R.F.and S.A.acknowledge the European Union’s Horizon 2020 research and innovation programme,project PlantaSYST(SGA-CSA No.739582 under FPA No.664620);the BG05M2OP001-1.003-001-C01 project;financed by the European Regional Devel-opment Fund through the Bulgarian’Science and Education for Smart Growth’Operational Programme.S.A.acknowledges the EU Horizon 2020,call HORIZON-WIDERA-2022-TALENTS-01,project NatGenCrop(grant agreement No.101087091).
In recent years,multiple advances have been made in understanding the photosynthetic machinery in model organisms.Knowledge transfer to horticultural important fruit crops is challenging and time-consuming due to rest...
关键词：ASSIMILATION METABOLISM consuming 
A Bacterial Cytochrome P450 Enzyme Catalyzes Multistep Oxidation Reactions in Pyrroindomycin Biosynthesis
《Chinese Journal of Chemistry》2023年第19期2439-2445,共7页Jiabao Wang Yu Xu Dandan Chen Jiang Tao Hongbo Wang Wen Liu 
supported in part by grants from the National Key Research and Development Program of China(2022YFC2303100);the National Natural Science Foundation of China(22193070,32030002,81974495 and 21977109);the Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZLCX20212401).
Cytochrome P450 enzymes (P450s) belong to a large family of oxidative hemeproteins and catalyze highly diverse oxygenation reactions that are involved in the biosynthesis of various natural products. Here, we report a...
关键词：Cytochrome P450 enzyme Pyrroindomycin Multistep oxidation reactions Enzyme catalysis SELECTIVITY 
Cytochrome P450 mediates the formation of four new citrinin metabolites
《Food Bioscience》2023年第3期1576-1583,共8页Yida Xu Yongli Ye Yahui Gao Xinyu Sun Jingdong Shao Xiulan Sun 
supported by the National Natural Science Foundation of China(32125031);the Fundamental Research Funds for the Central Universities(JUSRP222001);the Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province,Jiangnan University.
Citrinin(CIT)is one of by-products by Monascus fermentation with known nephrotoxicity.Except dihydro-citrinone,no other metabolites including the possible metabolic pathways have been found in vivo metabolism.In this ...
关键词：CITRININ METABOLISM Phase I Cytochrome 450 
Moorella thermoacetica:A promising cytochrome-and quinone-containing acetogenic bacterium as platform for a CO_(2)-based bioeconomy
《Green Carbon》2023年第1期2-13,共12页Florian P.Rosenbaum Volker Müller 
The negative effect of fossil-based industrial processes on the environment,especially the contribution to global warming by emitting greenhouse gases such as CO_(2) causes a global threat to mankind.Therefore,technol...
关键词：ANAEROBES Synthesis gas BIOENERGETICS THERMOPHILES Wood-Ljungdahl pathway 
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