METALLOENZYMES

作品数：7被引量：9H指数：2
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相关期刊：《Science China Chemistry》《Progress in Natural Science:Materials International》《Asian Pacific Journal of Tropical Biomedicine》《Synthetic and Systems Biotechnology》更多>>
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Luteolin attenuates diabetic nephropathy via inhibition of metalloenzymes in rats
《Asian Pacific Journal of Tropical Biomedicine》2023年第12期507-520,I0002,I0003,共16页R.B.Daude Rajendra Bhadane J.S.Shah 
supported by the Joe,Pentti,and Tor Borg Memorial Fund.
Objective:To investigate the renoprotective effects of luteolin on diabetes in rats.Methods:One week after administration of streptozotocin 55 mg/kg intraperitoneally,rats were given 25,50,and 75 mg/kg/day of luteolin...
关键词：MMPS HDAC-2 LUTEOLIN NRK-52E Diabetic nephropathy DOCKING Molecular dynamic simulations 
Chemical modifications of proteins and their applications in metalloenzyme studies被引量：2
《Synthetic and Systems Biotechnology》2021年第1期32-49,共18页Nathchar Naowarojna Ronghai Cheng Juan Lopez Christina Wong Lu Qiao Pinghua Liu 
This research was partially supported by National Science Foundation(CHE-2004109 to P.L.)。
Protein chemical modifications are important tools for elucidating chemical and biological functions of proteins.Several strategies have been developed to implement these modifications,including enzymatic tailoring re...
关键词：METALLOENZYMES Biorthogonal reactions Protein engineering Non-canonical amino acids BIOCATALYSIS 
Biosynthetic approach to modeling and understanding metalloproteins using unnatural amino acids被引量：1
《Science China Chemistry》2017年第2期188-200,共13页Yang Yu Chang Cui Jiangyun Wang Yi Lu 
supported by the US National Science Foundation(CHE-1413328);the Major State Basic Research Program of China(2015CB856203);the National Natural Science Foundation of China (21325211,31500641);theTianjinMunicipalGrant(13ZCZDSY04800, 14ZCZDSY00059,14JCYBJC43400)
Metalloproteins have inspired chemists for many years to synthesize artificial catalysts that mimic native enzymes.As a complementary approach to studying native enzymes or making synthetic models,biosynthetic approac...
关键词：metalloenzymes heme proteins copper proteins ribonucleotide reductase protein design 
Oxygenolysis reaction mechanism of copper-dependent quercetin 2,3-dioxygenase:A density functional theory study
《Science China Chemistry》2012年第9期1832-1841,共10页XIE HuJun LEI QunFang FANG WenJun 
supported by the National Natural Science Foundation of China (21073164,20673098);the Natural Science Foundation of Zhejiang Province (Y4100620);the Research Foundation of the Education Bureau of Zhejiang Province (Y200906517)
The mechanism of the action of copper-dependent quercetin 2,3-dioxygenase （2,3QD） has been investigated by means of hy- brid density functional theory. The 2,3QD enzyme cleaves the O-heterocycle of a quercetin by in...
关键词：quercetin 2 3-dioxygenase DFT calculations catalytic mechanism METALLOENZYMES oxygenolysis 
Simon Labbé's work on iron and copper homeostasis
《World Journal of Biological Chemistry》2010年第5期196-200,共5页Simon Labbé 
Supported by The Canadian Institutes for Health Research (MOP-36450 to LabbéS);Natural Sciences and Engineering Research Council of Canada(MOP-238238-2010 to LabbéS);the Fonds de la Recherche en Santédu Québec(Senior Investigator Scholarship to LabbéS)
Iron and copper have a wealth of functions in biological systems,which makes them essential micronutrients for all living organisms.Defects in iron and copper homeostasis are directly responsible for diseases,and have...
关键词：IRON and COPPER transport SYSTEMS Metalloregulatory sensors Iron-and copper-responsivegenes Metal TRAFFICKING pathways METALLOENZYMES Fungi as model SYSTEMS 
Metalloproteins/metalloenzymes for the synthesis of acetyl-CoA in the Wood-Ljungdahl pathway被引量：4
《Science China Chemistry》2009年第12期2071-2082,共12页ZHU XiaoFei1 & TAN XiangShi1,2 1 Department of Chemistry,Fudan University,Shanghai 200433,China 2 Institutes of Biomedical Sciences,Fudan University,Shanghai 200433,China 
Supported by the National Natural Science Foundation of China (Grant No. 20771029);Shanghai Pujiang Talent Project (Grant No. 08PJ14017);Shanghai Leading Academic Discipline Project (Grant No. B108)
This paper focuses on the group of metalloproteins/metalloenzymes in the acetyl-coenzyme A synthesis pathway of anaerobic microbes called Wood-Ljungdahl pathway,including formate dehydrogenase (FDH),corrinoid iron sul...
关键词：Wood-Ljungdahl PATHWAY formate DEHYDROGENASE corrinoid iron sulfur protein ACETYL-COA synthase CO DEHYDROGENASE 
Progress in study on metalloporphyrin mimicking metalloenzymes被引量：2
《Progress in Natural Science:Materials International》2002年第5期321-330,共9页JI Liangnian , PENG Xiaobin and HUANG Jinwang( Department of Chemistry, Zhongshan University, Guangzhou 510275,China Department of Applied Chemistry, South China University of Technology, Guangzhou 510641, China) 
Supported by the National Natural Science Foundation of China (Grant Nos. 298871036, 29731030, 30070188); State Key Laboratory of Coordination Chemistry in Nanjing University, The Natural Science Foundation of Guangdong Province, and Research Fund of Ro
The development of research on metalloporphyrins, which are used as model compounds for some metalloenzymes, is reviewed, including the survey of oxygen binding of heme, the catalytic oxidation of cytochrome P450, the...
关键词：metalloporphyrins  metalloenzymes  MODEL compound. 
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