TRAFFICKING

作品数：180被引量：527H指数：9
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相关领域：生物学更多>>
相关作者：全超陈帅陈亮周嘉伟陈剑峰更多>>
相关机构：中国科学院上海生命科学研究院复旦大学北京师范大学中国科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金江苏省自然科学基金更多>>
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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia
《Neural Regeneration Research》2025年第5期1397-1398,共2页Zhenyu Chen Xue-Jun Li 
supported by the NIH grant(RO1 NS118066);the Blazer Foundation(to XJL)。
Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower extre...
关键词：DEGENERATION DISEASES HEREDITARY 
Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking
《Military Medical Research》2025年第2期157-183,共27页Man-Xiu Xie Ren-Chun Lai Yi-Bin Xiao Xi Zhang Xian-Ying Cao Xiao-Yu Tian An-Nan Chen Zi-Yi Chen Yan Cao Xiao Li Xiao-Long Zhang 
National Natural Science Foundation of China(82271241 and 82001172 to XLZ,81801112 to MXX);Guangdong Basic and Applied Basic Research Foundation(2022A1515012389 to MXX,2022A1515012543 to RCL);Young Talent Support Project of Guangzhou Association for Science and Technology(QT20220101169 to XLZ);Excellent Young Talents Project of Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences(KY012021188 to XLZ);Science and Technology Projects in Guangzhou(202201010792 to RCL)。
Background Tactile and mechanical pain are crucial to our interaction with the environment,yet the underpinning molecular mechanism is still elusive.Endophilin A2(EndoA2)is an evolutionarily conserved protein that is ...
关键词：Endophilin A2 TOUCH Mechanical allodynia Piezo2 KIF5B 
A PRA-Rab trafficking machinery modulates NLR immune receptor plasma membrane microdomain anchoring and blast resistance in rice
《Science Bulletin》2025年第5期733-747,共15页Di Liang Dongyong Yang Tai Li Zhe Zhu Bingxiao Yan Yang He Xiaoyuan Li Keran Zhai Jiyun Liu Yoji Kawano Yiwen Deng Xu Na Wu Junzhong Liu Zuhua He 
Biological Breeding-National Science and Technology Major Projects(2023ZD04070);Chinese Academy of Sciences(XDA24010304 and XDB27040201);National Natural Science Foundation of China(32088102,31930090,31720103913,and 32070564);National Key Research and Development Program of China(2016YFD0100600);Postdoctoral Innovation Talents Support Program(BX20240376);Xingdian Talent Support Program of Yunnan Province(C619300A094);Yunnan Fundamental Research Projects(202301BF070001-013,202101AW070002,202201AT070090 and 202301AT070166).
Nucleotide-binding leucine-rich repeat(NLR)receptors mediate pathogen effector-triggered immunity(ETI)in plants,and a subclass of NLRs are hypothesized to function at the plasma membrane(PM).However,how NLR traffic an...
关键词：Prenylated Rab acceptor PigmR Trafficking vesicles OsRab5a Blast resistance 
Rab1 and Syntaxin 17 regulate hematopoietic homeostasis through β-integrin trafficking in Drosophila
《Journal of Genetics and Genomics》2025年第1期51-65,共15页Fangzhou Luo Luwei Sui Ying Sun Zhixian Lai Chengcheng Zhang Gaoqun Zhang Bing Bi Shichao Yu Li Hua Jin 
supported by the National Natural Science Foundation of China(32170484 and 32300384);the Fundamental Research Funds for the Central Universities(2572022DQ07 and 2572020AW04).
Hematopoiesis is crucial for organismal health,and Drosophila serves as an effective genetic model due to conserved regulatory mechanisms with vertebrates.In larvae,hematopoiesis primarily occurs in the lymph gland,wh...
关键词：HEMATOPOIESIS Lymphgland Rab1 Syntaxin 17 β-integrin DROSOPHILA 
TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation
《Oncology Research》2025年第1期161-169,共9页XIUWANG WEI JIANBO LIANG HUANWEN HUANG DAMING YANG XINXIN WANG XIUJIA WANG CHANGSHENG CHEN KAIQIANG LI TAISEN PANG BIN HU FENGNING WU 
supported by Guangxi Medical and Health Appropriate Technology Development and Promotion Application Project(S2022022).
Background:Transmembrane emp24 trafficking protein 3(TMED3)is associated with the development of several tumors;however,whether TMED3 regulates the progression of prostate cancer remains unclear.Materials and Methods:...
关键词：Prostate cancer Transmembrane emp24 trafficking protein 3(TMED3) forkhead box O transcription factor(FOXO) Proliferation Apoptosis 
The MON1–CCZ1 complex plays dual roles in autophagic degradation and vacuolar protein transport in rice
《Journal of Integrative Plant Biology》2025年第1期35-54,共20页Binglei Zhang Yihua Wang Yun Zhu Tian Pan Haigang Yan Xin Wang Ruonan Jing Hongming Wu Fan Wang Yu Zhang Xiuhao Bao Yongfei Wang Pengcheng Zhang Yu Chen Erchao Duan Xiaohang Han Gexing Wan Mengyuan Yan Xiejun Sun Cailin Lei Zhijun Cheng Zhichao Zhao Ling Jiang Yiqun Bao Yulong Ren Jianmin Wan 
supported by grants from the National Key R&D Program of China(2021YFF1000200);Innovation Program of Chinese Academy of Agricultural Sciences,International Science&Technology Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-ZDRW202109);National Natural Science Foundation of China(31830064 and 32172085);supported by the Central Public-Interest Scientific Institution Basal Research Fund,China(Y2021YJ18);Jiangsu Nanjing Rice Germplasm Resources National Field Observation and Research Station。
Autophagy is a highly conserved cellular program in eukaryotic cells which mediates the degradation of cytoplasmic components through the lysosome,also named the vacuole in plants.However,the molecular mechanisms unde...
关键词：autophagic degradation MON1–CCZ1 Rab7 RICE vacuolar trafficking 
Targeted degradation of membrane and extracellular proteins with LYTACs
《Acta Pharmacologica Sinica》2025年第1期1-7,共7页Yu-yang Li Yang Yang Ren-shuai Zhang Rui-xin Ge Song-bo Xie 
This work was supported by the National Natural Science Foundation of China(32270892 and 32070708);Henan Province Key Research and development and promotion special(Science and technology research):No.242102311036.
Targeted protein degradation technology has gained substantial momentum over the past two decades as a revolutionary strategy for eliminating pathogenic proteins that are otherwise refractory to treatment.Among the va...
关键词：targeted protein degradation lysosome targeting chimera lysosome-trafficking receptor extracellular protein membraneprotein 
Bis-benzylisoquinoline alkaloids inhibit flavivirus entry and replication by compromising endolysosomal trafficking and autophagy
《Virologica Sinica》2024年第6期892-908,共17页Lihong Huang Lele Liu Junhai Zhu Nanjun Chen Jie Chen Chuen-Fuk Chan Fei Gao Youqin Yin Jiufeng Sun Rongxin Zhang Kehui Zhang Wenbao Qi Jianbo Yue 
supported by the National Key Research and Development Program of China(2022YFD1800100);the National Natural Science Foundation of China(32302843,32070702,and 82161128014);GuangDong Basic and Applied Basic Research Foundation(2023A1515010748);Innovation and Technology Fund of Hong Kong(MRP/064/21,GHP/097/20GD,and MHP/072/21);Hong Kong Research Grant Council(RGC)grant(11103620 and 11104422);research grants from Shenzhen Science and Technology Innovation Committee(SGDX20201103093201010 and JCYJ20210324134007020);Kunshan Shuang Chuang Grant(kssc202302073);the Kunshan Municipal Government research funding。
Flaviviruses,such as dengue virus(DENV),Zika virus(ZIKV),and Japanese encephalitis virus(JEV),represent a substantial public health challenge as there are currently no approved treatments available.Here,we investigate...
关键词：Bis-benzylisoquinoline alkaloids(BBAs) FLAVIVIRUS Zika virus(ZIKV) Endolysosomes TRPML channels AUTOPHAGY 
Reevaluating Golgi fragmentation and its implications in wound repair
《Cell Regeneration》2024年第1期364-375,共12页Chandra Sugiarto Wijaya Suhong Xu 
National Key R&D Program of China(2021YFA1101002,2021YFA1300302);National Natural Science Foundation of China(92254303).
The Golgi Apparatus(GA)is pivotal in vesicle sorting and protein modifications within cells.Traditionally,the GA has been described as a perinuclear organelle consisting of stacked cisternae forming a ribbon-like stru...
关键词：Golgi apparatus Membrane repair TRAFFICKING Wound repair and regeneration Golgi fragmentation APOPTOSIS Cell division CANCER Neurodegenerative disease 
Mechanisms and applications:Cargos transport to basolateral membranes in polarized epithelial cells
《Chinese Chemical Letters》2024年第12期104-110,共7页Yinglan Yu Sajid Hussain Jianping Qi Lei Luo Xuemei Zhang 
supported by the China Postdoctoral Science Foundation(No.2023M740731);Fundamental Research Funds for the Central Universities(No.SWU-KQ22024);National Key Research and Development Program of China(No.2021YFD1800900);National Natural Science Foundation of China(No.82073790);the Chongqing Science and Technology Commission(No.CSTB2022TIAD-LUX0001)。
In polarized cells,the differential distribution of proteins results in the formation of apical and basolateral membranes.The basolateral membrane contacts basal lamina and mediates cell-to-cell communication,which is...
关键词：Polarized cells Basolateral trafficking Sorting signals Disease prediction Drug delivery 
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