Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia  

作　　者：Zhenyu Chen Xue-Jun Li 

机构地区：[1]Department of Biomedical Sciences,University of Illinois College of Medicine Rockford,Rockford,IL,USA [2]Department of Bioengineering,University of Illinois at Chicago,Chicago,IL,USA

出　　处：《Neural Regeneration Research》2025年第5期1397-1398,共2页中国神经再生研究（英文版）

基　　金：supported by the NIH grant(RO1 NS118066);the Blazer Foundation(to XJL)。

摘　　要：Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower extremities.HSP is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关 键 词：DEGENERATION DISEASES HEREDITARY 

分 类 号：R741[医药卫生—神经病学与精神病学]