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作品数：249被引量：329H指数：9
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相关领域：医药卫生农业科学更多>>
相关作者：孙凤艳李学君宋雷康连鸣刘新丽更多>>
相关机构：厦门大学台湾大学上海医科大学国家心血管病中心更多>>
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Functional analysis of SDR112C1 associated with fenpropathrin tolerance in Tetranychus cinnabarinus(Boisduval)
《Insect Science》2025年第2期585-599,共15页Jinhang Li Jialu Liu Lishu Peng Jingui Liu Lin Xu Junfeng He Longjiang Sun Guangmao Shen Lin He 
funded by the National Natural Science Foundation of China(U2202202);the National Key Research,Development Program of China(2023YFD1400000);Chongqing China Three Gorges Museum independent project(3GM2022-KTZ06).
Short-chain dehydrogenases/reductases(SDRs)are ubiquitously distributed across diverse organisms and play pivotal roles in the growth,as well as endogenous and exogenous metabolism of various substances,including drug...
关键词：fenpropathrin tolerance heterologous expression polyphagous mite shortchain dehydrogenase transgenic fruit fly 
Uncoupling of nutrient metabolism and cellular redox by cytosolic routing of the mitochondrial G-3-P dehydrogenase Gpd2 causes loss of conidiation and pathogenicity in Pyricularia oryzae
《Journal of Integrative Agriculture》2025年第2期638-654,共17页Wenqin Fang Yonghe Hong Tengsheng Zhou Yangdou Wei Lili Lin Zonghua Wang Xiaohan Zhu 
funded by the National Natural Science Foundation of China(32272513 and 31770156);the Natural Sciences and Engineering Research Council of Canada(Discovery Grant,RGPIN-2016-05356);the Canadian Foundation for Innovation(Discovery Grant,227398-2011)。
Oxidation of self-stored carbohydrates and lipids provides the energy for the rapid morphogenetic transformation during asexual and infection-related development in Pyricularia oryzae,which results in intracellular ac...
关键词：Pyricularia oryzae mitochondrial G-3-P dehydrogenase NAD+/NADH balance fungal virulence mitochondrial targeted signal 
Artificial cascade biocatalysis for the synthesis of 2-aminocyclohexanols with contiguous stereocenters
《Chinese Journal of Catalysis》2025年第1期345-355,共11页Fei-Xiang Dong Tian Jin Xiaojuan Yu Hong-Yue Wang Qi Chen Jian-He Xu Gao-Wei Zheng 
国家重点研发计划(2019YFA09005000);国家自然科学基金(21878085,31971380)。
Chiral cyclic amino alcohols with contiguous stereocenters are key building blocks in the synthesis of bioactive molecules and pharmaceuticals.Artificial cascade biocatalysis represents an attractive method for the sy...
关键词：BIOCATALYSIS Enzyme cascade AMINOALCOHOL Reductive aminase Amine dehydrogenase 
Molecular insight into the potential functional role of pseudoenzyme GFOD1 via interaction with NKIRAS2
《Acta Biochimica et Biophysica Sinica》2024年第9期1256-1266,共11页Jiawen Shi Xinyi Guo Chan Liu Yilun Wang Xiaobao Chen Guihua Wu Jianping Ding Tianlong Zhang 
supported by the grants from the National Natural Science Foundation of China(Nos.32070766,32271247 and 32071190);the National Key Research and Development Program of China(Nos.2020YFA0509000 and 2020YFA0803200);the Jiangsu Commission of Health(No.LKZ2023018).
The glucose-fructose oxidoreductase/inositol dehydrogenase/rhizopine catabolism protein(Gfo/Idh/MocA)family includes a variety of oxidoreductases with a wide range of substrates that utilize NAD or NADP as redox cofac...
关键词：crystal structure glucose-fructose oxidoreductase GFoD1 glucose-fructose oxidoreductase/inositol dehydrogenase/rhizopine catabolism protein(Gfo/ldh/MocA)family NKIRAS2 pseudoenzyme 
Fatal multiple acyl-CoA dehydrogenase deficiency caused by ETFDH gene mutation:A case report
《World Journal of Clinical Cases》2024年第23期5422-5430,共9页Xue-Xia Li Xiao-Nan Yang Hu-Dan Pan Liang Liu 
BACKGROUND Multiple acyl-CoA dehydrogenase deficiency(MADD)is a disease of rare autosomal recessive disorder.There are three types of MADD.Type I is a neonatalonset form with congenital anomalies.Type II is a neonatal...
关键词：Electron transfer flavoprotein dehydrogenase mutation Multiple acyl-CoA dehydrogenase deficiency Multiple organ failure Case report 
Low expression of fatty acid oxidation related gene ACADM indicates poor prognosis of renal clear cell carcinoma and is related to tumor immune infltration
《Oncology Research》2024年第3期545-561,共17页JIECHUAN QIU TIANMIN YANG YANNING SUN KAI SUN YINGKUN XU QINGHUA XIA 
the National Natural Science Foundation of China(Grant Nos.82072816 and 81672553);the Natural Science Foundation of Shandong Province(Grant No.ZR2021LZY003).
This research aims to identify the key fatty acid beta-oxidation(FAO)genes that are altered in kidney renal clear cell carcinoma(KIRC)and to analyze the role of these genes in KIRC The Gene Expression Omnibus(GEO)and ...
关键词：Kidney renal clear cell carcinoma Acyl CoA dehydrogenase medium chain Immune infiltration Fatty acid oxidation Prognosis 
Transfer RNA-derived fragment tRF-23-Q99P9P9NDD promotes progression of gastric cancer by targeting ACADSB
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第5期438-450,共13页Yu ZHANG Xinliang GU Yang LI Xun LI Yuejiao HUANG Shaoqing JU 
was supported by the National Natural Science Foundation of China(Nos.82272411 and 82072363);the Jiangsu Provincial Medical Key Discipline(Laboratory)(No.ZDXK202240);the Science and Technology Project of Jiangsu Province(No.BE2023741),China。
Gastric cancer(GC)is one of the most common gastrointestinal tumors.As a newly discovered type of non-coding RNAs,transfer RNA(tRNA)-derived small RNAs(tsRNAs)play a dual biological role in cancer.Our previous studies...
关键词：Transfer RNA(tRNA)-derived small RNA(tsRNA) Gastric cancer(GC) Acyl-coenzyme A dehydrogenase short/branched chain(ACADSB) Molecular mechanism Treatment Ferroptosis 
Structural and biochemical basis for the pathogenic mutations of methylmalonate semialdehyde dehydrogenase ALDH6A1
《Medicine Plus》2024年第4期19-30,共12页Gengchen Su Kaide Ju Youwei Xu Ye Jin Limeng Chen Xiaodong Luan 
supported by the National Key Research and Development Program of China (2023YFC3605504);the Innovation Fund for Medical Sciences from the Chinese Academy of Medical Sciences (2021-I2M-1-003);the National High-Level Hospital Clinical Research Funding (2022-PUMCH-D-002 and 2022-PUMCH-B-098)
Background: Methylmalonate semialdehyde dehydrogenase(ALDH6A1), encoded by the ALDH6A1 gene, is essential for the metabolic degradation of valine and thymine.Genetic alterations in ALDH6A1 lead to methylmalonate semia...
关键词：ALDH6A1 Methylmalonate semialdehyde dehydrogenase deficiency Disease mutations Enzyme activity 
Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma
《Hepatobiliary & Pancreatic Diseases International》2024年第1期35-42,共8页Li-Li Miao Jing-Wen Wang Hui-Hui Liu Shuai Gao Yu-Chen Fan Kai Wang 
This study was supported by grants from the Key Project of the Chinese Ministry of Science and Technology(2017ZX102022022);National Key Research and Development Program of China(2021YFC2301801).
Background: Glycine dehydrogenase(GLDC) plays an important role in the initiation and proliferation of several human cancers. In this study, we aimed to detect the methylation status of GLDC promoter and its diagnosti...
关键词：Hepatocellular carcinoma Glycine dehydrogenase DNA methylation Peripheral blood mononuclear cells 
Co-immobilization of amine dehydrogenase and glucose dehydrogenase for the biosynthesis of(S)-2-aminobutan-1-ol in continuous flow
《Bioresources and Bioprocessing》2024年第1期946-956,共11页Pengcheng Xie Jin Lan Jingshuan Zhou Zhun Hu Jiandong Cui Ge Qu Bo Yuan Zhoutong Sun 
supported by the National Key Research and Development Program of China(No.2021YFA0910400 and 2019YFA0905100);the National Natural Science Foundation of China(No.32171462);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(No.TSBICIP-CXRC-040);the Natural Science Foundation of Tianjin(No.21JCJQJC00110).
Reductive amination by amine dehydrogenases is a green and sustainable process that produces only water as the by-product.In this study,a continuous flow process was designed utilizing a packed bed reactor filled with...
关键词：Continuous flow Asymmetric reductive amination Amine dehydrogenases CO-IMMOBILIZATION Packed bed reactor 
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