Simon Labbé's work on iron and copper homeostasis  

作　　者：Simon Labbé 

机构地区：[1]Department of Biochemistry,Faculty of Medicine,Universitéde Sherbrooke,3001,12e Avenue Nord,Sherbrooke J1H 5N4,Canada

出　　处：《World Journal of Biological Chemistry》2010年第5期196-200,共5页世界生物化学杂志（英文版）（电子版）

基　　金：Supported by The Canadian Institutes for Health Research (MOP-36450 to LabbéS);Natural Sciences and Engineering Research Council of Canada(MOP-238238-2010 to LabbéS);the Fonds de la Recherche en Santédu Québec(Senior Investigator Scholarship to LabbéS)

摘　　要：Iron and copper have a wealth of functions in biological systems,which makes them essential micronutrients for all living organisms.Defects in iron and copper homeostasis are directly responsible for diseases,and have been linked to impaired development,metabolic syndromes and fungal virulence.Consequently,it is crucial to gain a comprehensive understanding of the molecular bases of iron-and copper-dependent proteins in living systems.Simon Labbémaintains parallel programs on iron and copper homeostasis using the fission yeast Schizosaccharomyces pombe(Schiz.pombe) as a model system.The study of fission yeast transition-metal metabolism has been successful,not only in discerning the genes and pathways functioning in Schiz.pombe,but also the genes and pathways that are active in mammalian systems and for other fungi.Iron and copper have a wealth of functions in biological systems, which makes them essential micronutrients for all living organisms. Defects in iron and copper homeostasis are directly responsible for diseases, and have been linked to impaired development, metabolic syndromes and fungal virulence. Consequently, it is crucial to gain a comprehensive understanding of the molecular bases of iron- and copper-dependent proteins in living systems. Simon Labbé maintains parallel programs on iron and copper homeostasis using the fission yeast Schizosaccharomyces pombe (Schiz. pombe) as a model system. The study of fission yeast transition-metal metabolism has been successful, not only in discerning the genes and pathways functioning in Schiz. pombe, but also the genes and pathways that are active in mammalian systems and for other fungi.

关 键 词：IRON and COPPER transport SYSTEMS Metalloregulatory sensors Iron-and copper-responsivegenes Metal TRAFFICKING pathways METALLOENZYMES Fungi as model SYSTEMS 

分 类 号：Q58[生物学—生物化学]