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Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy...
Supported by the National Key Research and Development Program of China(Grant No.2016YFA0400200);the National Natural Science Foundation of China(Grants No.11773075);the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.2016288).
According to models such as panspermia or the Nebula-Relay hypothesis,the ancestors of life on Earth once lived in molecular clouds.Then what are the energy source and bioenergetics for such lifeforms?A new bioenerget...
supported by Russian science foundation(grant 21-75-30009).
Background: The active use of stem and progenitor cells in the therapy of various diseases requires thedevelopment of approaches for targeted modification of their properties. One such approach is the induction of a p...
supported by National Institute of Health awards NS118000 and NS128049 (to GG)。
Neurons are energy-demanding cells.Disruptions in energy metabolism can quickly interrupt neuronal function,leading to cell death and neurodegeneration.For instance,ischemia rapidly depletes adenosine triphosphate(ATP...
supported by grants from the Region Occitanie/Pyrénées-Méditerranée(Grant No.1901175);the European Regional Development Fund(ERDF)(Grant No.MP0022856);This study received funding from la Fédération Française de Cardiologie”(FFC,Dotation Recherche),Alzheimer Prevention in Occitania and Catalonia(APOC Chair of Excellence-Inspire Program);Saint Louis University.The MAPT study was supported by grants from the Gérontopôle of Toulouse,the French Ministry of Health(PHRC 2008,2009);Pierre Fabre Research Institute(manufacturer of the omega-3 supplement);ExonHit Therapeutics SA,and Avid Radiopharmaceuticals,Inc.The promotion of this study was supported by the University Hospital Center of Toulouse;The data-sharing activity was supported by the Association Monegasque pour la Recherche sur la Maladie d'Alzheimer(AMPA)and the INSERM-University of Toulouse III UMR 1295(CERPOP)Research Unit.
Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy metabolism.IF1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains...
High glucose(HG)culture conditions in vitro and persistent exposure to hyperglycemia in diabetes patients are detrimental to stem cells,analogous to any other cell type in our body.It interferes with diverse signaling...
The negative effect of fossil-based industrial processes on the environment,especially the contribution to global warming by emitting greenhouse gases such as CO_(2) causes a global threat to mankind.Therefore,technol...
This work was supported by grants from the“Young Talent Support Plan”of Xi’an Jiaotong University(71211222010704)to N.Huang;the Intramural Research Program of NINDS,NIH(ZIA NS003029 and ZIA NS002946)to Z.-H.Sheng.
Central nervous system(CNS)neurons typically fail to regenerate their axons after injury leading to neurological impairment.Axonal regeneration is a highly energy-demanding cellular program that requires local mitocho...
Cells are open systems that exchange energy and molecules with their environment.As any material system,they perform all the complex activities required for homeostasis and reproduction,obeying the thermodynamic laws....
Supported by the Beijing Municipal Natural Science Foundation,No.7212068;the National Natural Science Foundation of China,No.81900747.
BACKGROUND The pancreatic islet microcirculation adapts its metabolism to cope with limited oxygen availability and nutrient delivery.In diabetes,the balance between oxygen delivery and consumption is impaired.Insulin...