Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production  

作　　者：Angelid Pabon Jagannatham Naidu Bhupana Ching-On Wong 

机构地区：[1]Department of Biological Sciences,Rutgers University,Newark,NJ,USA

出　　处：《Neural Regeneration Research》2025年第3期671-681,共11页中国神经再生研究（英文版）

基　　金：supported by the NIH grant R01AG081379 (to CW)。

摘　　要：Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关 键 词：AUTOPHAGY BIOENERGETICS endolysosome energy production GLYCOLYSIS metabolic reprogramming MITOCHONDRIA 

分 类 号：R36[医药卫生—病理学]