Associations between physical activity levels and ATPase inhibitory factor 1 concentrations in older adults  

作　　者：Jérémy Raffin Yves Rolland Annelise Genoux Guillaume Combes Mikael Croyal Bertrand Perret Sophie Guyonnet Bruno Vellas Laurent O.Martinez Philipe de Souto Barreto For the MAPT/DSA Group 

机构地区：[1]Institut du Vieillissement,Gérontopôle de Toulouse,Centre Hospitalo-Universitaire de Toulouse,Toulouse 31000,France [2]Centre d'Epidémiologie et de Recherche en Santédes Populations,UnitéMixte de Recherche 1295,Institut National de la Santéet de la Recherche Médicale,UniversitéToulouse-III-Paul-Sabatier,Toulouse 31000,France [3]LimitAging Team,Institut des Maladies Métaboliques et Cardiovasculaires,UnitéMixte de Recherche 1297,Institut National de la Santéet de la Recherche Médicale,UniversitéToulouse III-Paul Sabatier,Toulouse 31432,France [4]Service de Biochimie,Pôle de biologie,Hôpital de Purpan,Centre Hospitalo-Universitaire de Toulouse,Toulouse 31300,France [5]L'Institut du Thorax,Institut National de la Santéet de la Recherche Médicale,Centre National de la Recherche Scientifique,Centre Hospitalo-Universitaire de Nantes,Nantes Université,Nantes 44000,France [6]BioCore,US16,Structure Fédérative de Recherche Bonamy,Institut National de la Santéet de la Recherche Médicale,Centre National de la Recherche Scientifique,Centre Hospitalo-Universitaire de Nantes,Nantes Université,Nantes 44000,France [7]Plate-forme de spectrométrie de masse,Centre de Recherche en Nutrition HumaineOuest,Nantes 44000,France [8]不详

出　　处：《Journal of Sport and Health Science》2024年第3期409-418,共10页运动与健康科学（英文）

基　　金：supported by grants from the Region Occitanie/Pyrénées-Méditerranée(Grant No.1901175);the European Regional Development Fund(ERDF)(Grant No.MP0022856);This study received funding from la Fédération Française de Cardiologie”(FFC,Dotation Recherche),Alzheimer Prevention in Occitania and Catalonia(APOC Chair of Excellence-Inspire Program);Saint Louis University.The MAPT study was supported by grants from the Gérontopôle of Toulouse,the French Ministry of Health(PHRC 2008,2009);Pierre Fabre Research Institute(manufacturer of the omega-3 supplement);ExonHit Therapeutics SA,and Avid Radiopharmaceuticals,Inc.The promotion of this study was supported by the University Hospital Center of Toulouse;The data-sharing activity was supported by the Association Monegasque pour la Recherche sur la Maladie d'Alzheimer(AMPA)and the INSERM-University of Toulouse III UMR 1295(CERPOP)Research Unit.

摘　　要：Background:Adenosine triphosphatase inhibitory factor 1(IF1)is a key protein involved in energy metabolism.IF1 has been linked to various agerelated diseases,although its relationship with physical activity(PA)remains unclear.Additionally,the apolipoprotein A-I(apoA-I),a PA-modulated lipoprotein,could play a role in this relationship because it shares a binding site with IF1 on the cell-surface ATP synthase.We examined here the associations between chronic PA and plasma IF1 concentrations among older adults,and we investigated whether apoA-I mediated these associations.Methods:In the present work,1096 healthy adults(63.8%females)aged 70 years and over who were involved in the Multidomain Alzheimer Prevention Trial study were included.IF1 plasma concentrations(square root of ng/mL)were measured at the 1-year visit of the Multidomain Alzheimer Prevention Trial,while PA levels(square root of metabolic equivalent task min/week)were assessed using questionnaires administered each year from baseline to the 3-year visit.Multiple linear regressions were performed to investigate the associations between the first-year mean PA levels and IF1 concentrations.Mediation analyses were conducted to examine whether apoA-I mediated these associations.Mixedeffect linear regressions were carried out to investigate whether the 1-year visit IF1 concentrations predicted subsequent changes in PA.Results:Multiple linear regressions indicated that first-year mean PA levels were positively associated with IF1 concentrations(B=0.021;SE=0.010;p=0.043).Mediation analyses revealed that about 37.7%of this relationship was mediated by apoA-I(B_(ab)=0.008;SE=0.004;p=0.023).Longitudinal investigations demonstrated that higher concentrations of IF1 at the 1-year visit predicted a faster decline in PA levels over the subsequent 2 years(time×IF1:B=0.148;SE=0.066;p=0.025).Conclusion:This study demonstrates that regular PA is associated with plasma IF1 concentrations,and it suggests that apoA-I partly mediates this association.Additionally,this study

关 键 词：Aging APOLIPOPROTEIN BIOENERGETICS Exerkine MITOCHONDRIA 

分 类 号：G804.2[文化科学—运动人体科学]