GLUCOTOXICITY

作品数：4被引量：9H指数：1
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相关领域：医药卫生更多>>
相关作者：严丹更多>>
相关机构：深圳大学更多>>
相关期刊：《Acta Biochimica et Biophysica Sinica》《Journal of Diabetes Mellitus》《World Journal of Diabetes》《Journal of Traditional Chinese Medicine》更多>>
相关基金：国家自然科学基金更多>>
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Role of insulin in pancreatic microcirculatory oxygen profile and bioenergetics
《World Journal of Diabetes》2022年第9期765-775,共11页Bing-Wei Li Yuan Li Xu Zhang Sun-Jing Fu Bing Wang Xiao-Yan Zhang Xue-Ting Liu Qin Wang Ai-Ling Li Ming-Ming Liu 
Supported by the Beijing Municipal Natural Science Foundation,No.7212068;the National Natural Science Foundation of China,No.81900747.
BACKGROUND The pancreatic islet microcirculation adapts its metabolism to cope with limited oxygen availability and nutrient delivery.In diabetes,the balance between oxygen delivery and consumption is impaired.Insulin...
关键词：Diabetes mellitus GLUCOTOXICITY Endothelial cells MICROCIRCULATION MITOCHONDRIA BIOENERGETICS 
Mulberry leaf flavonoids protect against glucotoxicity-induced INS-1 cell apoptosis被引量：8
《Journal of Traditional Chinese Medicine》2019年第2期153-159,共7页Wang Ying Li Ming Yu Xuesong He Sheng Wu Xinrong Wang Yan 
Supported by the Natural Science Foundation of China(No.81673608);Guangdong Science and Technology Project(No.2015A020211034);Guangzhou Science and Technology Project(No.201707010155):Study on Targeting Delivery to Liver by Sinomenine-Encapsulating Exosomes of Human Hepatic Stem Cells and Molecular Mechanism
OBJECTIVE:To investigate the effect of mulberry leaf flavonoids (MLF) on apoptosis of pancreatic cells induced by high glucose.METHODS:Long exposure to high glucose induces apoptosis of pancreaticβcells, which can le...
关键词：MORUS Plant leaves In suli no ma Flavon oids Toxicity Apoptosis 
Down-regulation of CASK in glucotoxicity- nduced insulin dysfunction in pancreatic β cells被引量：1
《Acta Biochimica et Biophysica Sinica》2018年第3期281-287,共7页Yao Wang Nana Hao Haiyan Lin Tianyuan Wang Jinyang Xie Yuexing Yuan 
High-glucose level exerts deleterious effects on pancreatic β cells, but the mechanisms remain unclear. Calcium/calmodulin-dependent serine protein kinase （CASK） plays a vital role in neural development and release...
关键词：GLUCOTOXICITY INSULIN calcium/calmodulin-dependent serine protein kinase hypoxia-inducible factor 1α 
Impact of glucotoxicity induced <i>in vivo</i>and <i>in vitro</i>in <i>Psammomys obesus</i>
《Journal of Diabetes Mellitus》2012年第1期59-71,共13页Berdja Sihem Smail Leila Othmani Kheira Neggazi Samia Hamlat Nadjiba Boumaza Saliha Sahraoui Abdelhamid Kacimi Ghouti Haffaf El Mahdi Benazzoug Yasmina Aouichat Bouguerra Souhila 
Objective: Chronic hyperglycemia characteristic of type diabetes 2 is responsible for the accelerated atherosclerosis with increased cardiovascular risk. In this study, we will propose to analyze the effect of a long-...
关键词：Psammomys Obesus AORTA Adventitial FIBROBLASTS in Culture DT2 GLUCOTOXICITY EXTRACELLULAR Matrix Oxidative Stress 
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