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METABOLITE: 作品数：350被引量：985H指数：15; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李宏森潘智文黄克建刘志青石世学更多>>; 相关机构：北京大学中国医学科学院北京协和医学院中国科学院广西壮族自治区公安厅更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?: 《Neural Regeneration Research》2026年第2期648-658,共11页Shuangchan Wu Jun Chen; supported by grants from Guangdong Basic and Applied Basic Research Foundation,No.2021A1515110801(to SW);the National Natural Science Foundation of China,No.82301511(to SW);“Double First-Class”Construction Project of NPU,Nos.0515023GH0202320(to JC),0515023SH0201320(to JC)and 973 Program,No.2011CB504100(to JC).; Myelination,the continuous ensheathment of neuronal axons,is a lifelong process in the nervous system that is essential for the precise,temporospatial conduction of action potentials between neurons.Myelin also provid...; 关键词：aging Alzheimer’s disease multiple sclerosis MYELIN myelin-axon metabolite crosstalk myelinodegeneration neurodegenerative disease OLIGODENDROCYTE Parkinson’s disease white matter

The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration: 《Neural Regeneration Research》2025年第10期2741-2757,共17页Qianzi Jin Suyu Wang Yujia Yao Qin Jiang Keran Li; supported by the National Natural Science Foundation of China,No.82171080;Nanjing Medical Science and Technology Development Project,No.YKK23264;Postgraduate Research&Practice Innovation Program of Jiangsu Province,Nos.JX10414151,JX10414152(all to KL)。; Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts vision.Unfortunately,the specific pathogenesis remains unclear,and effective early treatment options are...; 关键词：age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora METABOLITE MICROECOLOGY neurodegenerative disease

Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia被引量：1: 《Neural Regeneration Research》2025年第6期1705-1706,共2页Kazuki Watanabe Atsuhiko Hattori; supported by JSPS KAKENHI Grant Number JP22K11823 to AH and JP22J01508 to KW。; Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian clock.The hormone is primarily synthesized by the vertebrate pinea...; 关键词：metabolism primarily AGENT

Metabolome and RNA-seq reveal discrepant metabolism and secretory metabolism profile in skeletal muscle between obese and lean pigs at different ages: 《Science China(Life Sciences)》2025年第4期1102-1117,共16页Liu Guo Junfei Xu Wenyue Zhou Sisi Chen Hanjing Shi Mengmeng Han Zekun Yang Yehui Duan Weijun Pang Yulong Yin Fengna Li; supported by the National Natural Science Foundation of China(31972582);the STI 2030-Major Project(2023ZD04072);the Major Project of Changsha City(kh2401015);the Science and Technology Innovation Program of Hunan Province(2021RC4039);the Key Research and Development Program of Hunan Province(2022NK2026);the Youth Innovation Promotion Association CAS(Y202079);China Agriculture Research System of MOF and MARA(CARS-35)。; Metabolites and metabolism-related gene expression profiles in skeletal muscle change dramatically under obesity,aging and metabolic disease.Since obese and lean pigs are ideal models for metabolic research.Here,we co...; 关键词：skeletal muscle METABOLOME transcriptome biomarker metabolite intercellular communication lipid deposition pig model

Detection of Small Molecular Metabolites by Ambient Mass Spectrometry for Clinical Applications: 《Chemical Research in Chinese Universities》2025年第2期181-195,共15页YE Jiali YIN Yiyan OUYANG Jin NA Na; supported by the National Key Research and Development Program of China(No.2024YFA1509600);the National Natural Science Foundation of China(Nos.22474010,22274012);the Fundamental Research Funds for the Central Universities,China(No.2233300007).; Detection of small molecular metabolites in the body can reflect the overall health status of the human body, being essential for understanding metabolism and diagnosing diseases. For the detection and monitoring of s...; 关键词：Ambient mass spectrometry Small molecular metabolite METABOLISM DISEASE

A novel metabolite-interacting protein(MIP)-based molecular subtyping construction and validation of IGFBP3 as a MiP-related oncogene in colorectal cancer: 《Genes & Diseases》2025年第2期7-10,共4页Simeng Bao Yongmin Li Yu Liang Jianxun Dai Huolin Huang Bin Ma; supported by grants from the Cultivation Program of National Science Foundation of Liaoning Cancer Hospital (China) (No.2021-ZLLH-03);Beijing Xisike Clinical Oncology Research Foundation (China) (No.Y-QL202101-0039);Medical and Industrial Cross Joint Fund of Dalian University of Technology-Liaoning Cancer Hospital (China) (No.LD2023027);The National Natural Science Foundation of China (No.82303131);the Liaoning Province Science and Technology Plan Joint Program (Applied Basic Research Project) (China) (No.2023JH2/101700150).; For prognosis and therapeutic response,colorectal cancer(CRC)patients are highly variable across stages,correlated to high inter-tumor heterogeneity at the molecular level.1 Therefore,molecular subtyping needs to be d...; 关键词：colorectal cancer IGFBP3

Gut microbiota differences,metabolite changes,and disease intervention during metabolic-dysfunction-related fatty liver progression: 《World Journal of Hepatology》2025年第3期50-66,共17页Jian-Zhong Shu Yu-Han Huang Xiao-Hong He Feng-Ying Liu Qian-Qian Liang Xue-Tong Yong Yong-Fang Xie; Supported by Natural Science Foundation of Chongqing,No.cstc2021jcyj-msxmx0848;Chongqing Bishan Scientific Research Project,No.BSKJ2022006;National Natural Science Foundation of China,No.81773954;National College Students Innovation and Entrepreneurship Program,No.202310617015.; In the current era,metabolic dysfunction-associated steatotic liver disease(MASLD)has gradually developed into a major type of chronic liver disease that is widespread globally.Numerous studies have shown that the gut...; 关键词：Metabolic dysfunction-associated steatotic liver disease Gut microbiota Short-chain fatty acids Bile acids LIPOPOLYSACCHARIDES PROBIOTICS

Reevaluating statistical methods in metabolomic studies:A case for Spearman’s correlation: 《Molecular Plant》2025年第3期383-383,共1页Yoshiyasu Takefuji; Dear Editor,Recently,Liang et al.(2024)conducted comprehensive genome resequencing and metabolomic analyses of 299 representative accessions from extant citrus species,offering an extensive overview of genetic diversi...; 关键词：correlation analysis Spearman s correlation metabolomic studies genetic diversity metabolic profiles metabolomic analyses genome resequencing annotated metabolites metabolite content

Metabolite is a part of immune-regulating circuit: 《Cell Research》2025年第3期159-160,共2页Han Wang Shi-Min Zhao; Metabolites play a critical role in regulating cell signaling by interacting with proteins either noncovalently or covalently,with spontaneous modifications being less understood.In a recent Cell Research study,Zhao e...; 关键词：s d lactoylglutathione immune regulating circuit maintaining immune homeostasis cell signaling regulating cell signaling protein interaction spontaneous modifications METABOLITES

Changes in microorganisms and metabolites during long-term fermentation of commercially manufactured anchovy sauce: 《Food Science and Human Wellness》2025年第1期203-211,共9页Dae-Hyun Kim Seong-Eun Park Eun-Ju Kim Seung-Ho Seo Kwang-Moon Cho Sun-Jae Kwon Hong-Seok Son; supported by the National Research Foundation of Korea(NRF)(RS-2024-00333618 and RS-2023-00240999);a Korea University Grant;the Institute of Biomedical Science&Food Safety,CJ-Korea University Food Safety Hall at Korea University,Republic of Korea。; This study was performed to investigate the changes in microbial communities and metabolites during the long-term fermentation of commercially manufactured anchovy sauce.Samples of commercial anchovy sauce were collec...; 关键词：Fish sauce Salted anchovy Long-term fermentation MICROBIOME METABOLITE

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