The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration  

作　　者：Qianzi Jin Suyu Wang Yujia Yao Qin Jiang Keran Li 

机构地区：[1]Department of Ophthalmology,The Affiliated Eye Hospital of Nanjing Medical University,Nanjing,Jiangsu Province,China [2]The Fourth School of Clinical Medicine,Nanjing Medical University,Nanjing,Jiangsu Province,China

出　　处：《Neural Regeneration Research》2025年第10期2741-2757,共17页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.82171080;Nanjing Medical Science and Technology Development Project,No.YKK23264;Postgraduate Research&Practice Innovation Program of Jiangsu Province,Nos.JX10414151,JX10414152(all to KL)。

摘　　要：Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts vision.Unfortunately,the specific pathogenesis remains unclear,and effective early treatment options are consequently lacking.The microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a host.The intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other factors.Such dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many diseases.In recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the brain.Indeed,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s disease.Similarly,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular disorders.Moreover,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable etiologies.As such,the intestinal flora may play an important role in age-related macular degeneration.Given the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic strategies.Currently,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular degeneration.Organ-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the intestinal flora with research on metabolite

关 键 词：age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora METABOLITE MICROECOLOGY neurodegenerative disease 

分 类 号：R741[医药卫生—神经病学与精神病学] R774.5[医药卫生—临床医学]