OSTHOLE

作品数:30被引量:109H指数:7
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相关领域:医药卫生更多>>
相关作者:张露蓉宋占军李昱方均建吴胜明更多>>
相关机构:苏州大学军事医学科学院南京医科大学台北医学大学更多>>
相关期刊:《Journal of Northeast Agricultural University(English Edition)》《Journal of Pharmaceutical Analysis》《Advanced Agrochem》《分析测试学报》更多>>
相关基金:国家自然科学基金山东省自然科学基金上海市自然科学基金河北省自然科学基金更多>>
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Preparation of oximoether derivatives of osthole and their pesticidal properties
《Advanced Agrochem》2023年第2期173-179,共7页Zili Ren Min Lv Yuling Zhang Jiawei Du Hui Xu 
funded by the National Natural Science Foundation of China(Project No.32172453).
To explore non-food bioactive products for pesticide candidates,and high value-added application of crop plants in agriculture,by using osthole(a natural coumarin isolated from a Chinese herbal medicine Cnidium monnie...
关键词:OSTHOLE Bioactive product Pesticidal activity Structural modification Control efficiency 
Pharmacological Effects and Molecular Mechanism of Osthole
《Medicinal Plant》2023年第2期93-96,共4页Yannan LI Wenshuang HOU Jinglong CAO Anqi WANG Yinghua LUO Chenghao JIN 
Supported by the Talent Training Program for the Reform and Development of Local Colleges and University of the Central Government(2020GSP16);Postgraduate Innovative Research Project of Heilongjiang Bayi Agricultural University(YJSCX2022-Y59)。
Osthole has various pharmacological effects such as anti-cancer,anti-inflammation,prevention and treatment of cardiovascular diseases and neuroprotection.This paper reviews the advances in the research of the pharmaco...
关键词:OSTHOLE Pharmacological effects ANTI-CANCER ANTI-INFLAMMATION Prevention and treatment of cardiovascular diseases NEUROPROTECTION 
Osthole ameliorates myonecrosis caused by Clostridium perfringens type A infection in mice
《One Health Advances》2023年第1期52-61,共10页Xueyong Zhang Yue Liu Zhangqi Shen Shaolin Wang Congming Wu Dejun Liu Shusheng Tang Chongshan Dai 
funded by Laboratory of Lingnan Modern Agriculture Project(Award number NT2021006);supported by the National Natural Science Foundation of China(Award number 32102724);Pinduoduo-China Agricultural University Research Fund(No.PC2023A01002).
This study aimed to investigate the protective effect of the nature product osthole(OST)against Clostridium perfrin-gens type A infection-caused myonecrosis in a mouse model.Male mice were divided into(1)control,(2)in...
关键词:C.perfringens MYONECROSIS OSTHOLE Nrf2/HO-1 pathway NF-κB pathway 
Osthole inhibits the migration and invasion of highly metastatic breast cancer cells by suppressing ITGα3/ITGβ5 signaling被引量:6
《Acta Pharmacologica Sinica》2022年第6期1544-1555,共12页Yue-qiang Chen Hai-yan Song Zhong-yan Zhou Jiao Ma Zhan-yang Luo Ying Zhou Jian-yi Wang Sheng Liu Xiang-hui Han 
This work was supported by the National Natural Science Foundation of China(Nos.81573973 and 81774308);the Natural Science Foundation of Shanghai(No.20ZR1458600);the Outstanding Traditional Chinese Medicine Academic Leader Program of Shanghai(No.ZY(2018-2020)-RCPY-1011).
Metastasis is the leading cause of death in breast cancer patients.Osthole,as an active compound detected in the traditional Chinese medicine Wenshen Zhuanggu Formula,has shown a promising anti-metastatic activity in ...
关键词:OSTHOLE Wenshen Zhuanggu Formula breast cancer metastasis ITGα3 ITGβ5 FAK/Src/Rac1 pathway 
Osthole attenuates pulmonary arterial hypertension by modulation of phospholipid metabolism
《中国药理学与毒理学杂志》2021年第10期729-730,共2页FU Min LI Yuan YAO Li 
OBJECTIVE Pulmonary arterial hypertension(PAH)is a malignant pulmonary vascular disease lacking efficacy therapeutics.Therefore,it urgently needs to develop safe and effective drugs for PAH treatment.Osthole derived f...
关键词:OSTHOLE pulmonary arterial hypertension functional metabolomics phospholipid metabolism 
SARS-CoV-2:structure,host,virus source and pathogenesis
《Asian Journal of Traditional Medicines》2021年第1期32-52,共21页Mingxue Li Yueying Yang Yang Liu Mengzhu Zheng Dejuan Sun Hua Li Lixia Chen 
Cancer is a serious threat to human life and a big problem in clinical treatment.Some natural active substances extracted from Traditional Chinese Medicine can effectively inhibit the growth of cancer cells,which is a...
关键词:OSTHOLE anticancer effects molecular mechanisms 
Research progress on anticancer effects and molecular mechanisms of osthole
《Asian Journal of Traditional Medicines》2021年第1期53-62,共10页Jiayi Bi Zixuan Gao Guogang Zhang Yu Chen 
Cancer is a serious threat to human life and a big problem in clinical treatment.Some natural active substances extracted from Traditional Chinese Medicine can effectively inhibit the growth of cancer cells,which is a...
关键词:OSTHOLE anticancer effects molecular mechanisms 
Osthole attenuates pulmonary arterial hypertension by the regulation of sphingosine 1-phosphate in rats被引量:3
《Chinese Journal of Natural Medicines》2020年第4期308-320,共13页YAO Li YANG Yu-Xia CAO Hui REN Huan-Huan NIU Zheng SHI Ling 
the National Natural Science Foundation of China Grants (No. 81302764);the Science and Technology Grant for Excellent Talents of Harbin (No.2017RAXXJ060)。
Osthole is observed to have the capacity to treat pulmonary arterial hypertension(PAH) in rats, but molecular mechanism is still unknown. The present study aims to discover therapeutic targets and explore therapeutic ...
关键词:Pulmonary arterial hypertension OSTHOLE Metabolomics Sphk1/S1P MicroRNA-21-PI3K/Akt/mTOR Therapeutic mechanism 
Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats被引量:1
《Journal of Traditional Chinese Medicine》2019年第4期492-501,共10页Huang Ying Kong Liting Wang Yanping Sun Mingjie Cui Haifeng Zhai Huaqiang LüCheng Fan Danping 
Supported by National Natural Science Foundation of China(Study on the association between the composition of pungent traditional Chinese medicine and the effect of promoting blood circulation,No.81273901)
OBJECTIVE: To investigate the effect of osthole on isolated thoracic aortic rings, and to determine the potential mechanism of action.METHODS: Thoracic aortas were isolated from Wistar rats, and were suspended in tiss...
关键词:Aorta thoracic OSTHOLE PHENTOLAMINE VERAPAMIL VASORELAXATION Calcium Nitric oxide 
Osthole prevents cognitive impairment through modulating neuron cells in Aβ25-35-injected mice
《中国药理学与毒理学杂志》2019年第6期417-418,共2页HOU Xue-qin 
National Natural Science Foundation of China(81703901);Shandong Province Natural Science Foundation of China(ZR2016HB56)
OBJECTIVE To investigate the effects of osthole on learning and memory impairment of AD mice induced by injection of Aβ25-35 and the content of Ca2+, GLU and Aβ1-42 in the brain tissue and peripheral blood. METHODS ...
关键词:OSTHOLE ALZHEIMER DISEASE AΒ25-35 spatial learning and MEMORY 
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