VASORELAXATION

作品数：20被引量：74H指数：5
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相关领域：医药卫生更多>>
相关作者：鲁蓉汤聿海邓汉武彭长福李元建更多>>
相关机构：湖南医科大学南京医科大学沈阳药科大学更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Journal of Diabetes Mellitus》《Acta Pharmacologica Sinica》《中国药理学通报》更多>>
相关基金：国家自然科学基金北京市自然科学基金更多>>
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Vasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diab
《World Journal of Diabetes》2024年第6期1122-1141,共20页Sadettin Demirel 
Endothelial function plays a pivotal role in cardiovascular health,and dysfunction in this context diminishes vasorelaxation concomitant with endothelial activity.The nitric oxide-cyclic guanosine monophosphate pathwa...
关键词：Medicinal plants VASORELAXATION ENDOTHELIUM DIABETES ANTI-DIABETIC 
Mechanisms underlying the vascular relaxation activities of Zingiber officinale var. rubrum in thoracic aorta of spontaneously hypertensive rats被引量：1
《Journal of Integrative Medicine》2020年第1期46-58,共13页Nadiah Razali Aidiahmad Dewa Mohd Zaini Asmawi Nornisah Mohamed Nurul Maizan Manshor 
supported by the Fundamental Research Grant Scheme,Ministry of Higher Education,Malaysia(203/PFARMASI/6711408);MyPhD(MyBrain programme),Ministry of Higher Education,Malaysia.
Objective: To evaluate vasorelaxant and vasoconstriction effects of Zingiber officinale var. rubrum(ZOVR)on live rats and isolated aortic rings of spontaneously hypertensive rats(SHRs).Methods: Extracts of ZOVR were s...
关键词：ZINGIBER officinale var.rubrum VASORELAXATION VASOCONSTRICTION Aortic rings HERBAL medicine 
Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats被引量：1
《Journal of Traditional Chinese Medicine》2019年第4期492-501,共10页Huang Ying Kong Liting Wang Yanping Sun Mingjie Cui Haifeng Zhai Huaqiang LüCheng Fan Danping 
Supported by National Natural Science Foundation of China(Study on the association between the composition of pungent traditional Chinese medicine and the effect of promoting blood circulation,No.81273901)
OBJECTIVE: To investigate the effect of osthole on isolated thoracic aortic rings, and to determine the potential mechanism of action.METHODS: Thoracic aortas were isolated from Wistar rats, and were suspended in tiss...
关键词：Aorta thoracic OSTHOLE PHENTOLAMINE VERAPAMIL VASORELAXATION Calcium Nitric oxide 
Chenopodium ambrosioides induces an endothelium-dependent relaxation of rat isolated aorta
《Journal of Integrative Medicine》2019年第2期115-124,共10页Asmae Assaidi Ikram Dib Monique Tits Luc Angenot Said Bellahcen Nourelhouda Bouanani Abdelkhaleq Legssyer Mohammed Aziz Hassane Mekhfi Mohammed Bnouham Michel Frederich Abderrahim Ziyyat 
sponsored by funding from CNRST, Morocco (Project URAC-40);from Belgium (Program 3, CUD Project)
Objective: This study aims to evaluate the vasodilatory effect of Chenopodium ambrosioides on the isolated rat aorta, and to explore its mechanism of action.Methods: The vasorelaxant effect and the mode of action of v...
关键词：CHENOPODIUM ambrosioides CHENOPODIACEAE VASORELAXATION Ca^2+-activated potassium channels THIN-LAYER CHROMATOGRAPHY High-performance liquid CHROMATOGRAPHY Plant Complementary and alternative medicine 
Mitochondrial uncoupler triclosan induces vasorelaxation of rat arteries被引量：3
《Acta Pharmaceutica Sinica B》2017年第6期623-629,共7页Xiyue Zhang Xinzi Zhang Yanqiu Zhang Mingyu Liu Jing Jin Jie Yan Xin Shen Nan Hu Deli Dong 
supported by the National Natural Science Foundation of China(Grant Nos.81373406 and 81421063)
Our previous studies found that mitochondrial uncouplers induced vasodilation. Triclosan, the broad spectrum antibacterial agent, is the active ingredient in soaps and toothpastes. It was reported that triclosan induc...
关键词：TRICLOSAN Mitochondrial uncoupling Artery Smooth muscle cells VASORELAXATION 
Arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells:comparison of vasorelaxant effects of verapamil and phentolamine被引量：5
《Acta Pharmaceutica Sinica B》2017年第3期319-325,共7页Jing Jin Xin Shen Yu Tai Shanliang Li Mingyu Liu Changlin Zhen Xiuchen Xuan Xiyue Zhang Nan Hu Xinzi Zhang Deli Dong 
supported by the National Natural Science Foundation of China(Grant Nos.81373406 and 81421063)
Mitochondria are morphologically dynamic organelles which undergo fission and fusion processes. Our previous study found that arterial constriction was always accompanied by increased mitochondrial fission in smooth m...
关键词：ARTERY Mitochondrial fission PHENTOLAMINE VASORELAXATION VERAPAMIL 
Endothelium-independent vasorelaxant effect of 20（S）-protopanaxadiol on isolated rat thoracic aorta被引量：5
《Acta Pharmacologica Sinica》2016年第12期1555-1562,共8页Lu GAN Zhen-hua WANG Hong ZHANG Xin ZHOU Hui ZHOU Chao SUN Jing SI Rong ZHOU Cheng-jun MA Ji LI 
This work was supported by grants from the Key Program of National Natural Science Foundation of China （No U1432248）, National Key Projects of Research and Development （No 2016YFC0904600）, National Natural Science Foundation of China （No 11305226 and 11405230）, Taishan Scholar Program of Shandong Province （No tshw201502046）, and the Western Talent Program of Chinese Academy of Sciences （No 2013-165 and Y460030XB0）.
Aim： Ginsenosides are considered to be the major pharmacologically active ginseng constituents, whereas 20（S）-protopanaxadiol [20（S）-PPD] is the active metabolite of ginsenosides in gut. In this study we investig...
关键词：Ginsen 20（S）-protopanaxadiol VASORELAXATION aortic rings potassium channels calcium channels 
DL0805-2, a novel indazole derivative, relaxes angiotensin II-induced contractions of rat aortic rings by inhibiting Rho kinase and calcium fluxes被引量：5
《Acta Pharmacologica Sinica》2016年第5期604-616,共13页Tian-yi YUAN Yu-cai CHEN Hui-fang ZHANG Li LI Xiao-zhen JIAO Ping XIE Lian-hua FANG Guan-hua DU 
Aim： DL0805-2 [N-（1H-indazol-5-yl）-1-（4-methylbenzyl） pyrrolidine-3-carboxamide] is a DL0805 derivative with more potent vasorelaxant activity and lower toxicity. This study was conducted to investigate the vasor...
关键词：DL0805-2 angiotensin II VASORELAXATION Rho/ROCKs Ca^2＋ fluxes rat aortic ring vascular smooth muscle cells 
Vasorelaxation Effect of Gastrodin on Isolated Thoracic Aorta Rings of Rats被引量：11
《Chinese Journal of Integrative Medicine》2015年第12期944-948,共5页谢远龙 周敏 马会浩 王想 刘菊菊 
Supported by Undergraduate Scientific and Technological Innovation Project of Medical College of Three Gorges University,China(No.201105018)
Objective： To study the effect of gastrodin on isolated thoracic aorta rings of rats and to investigate the potential mechanism. Methods： A perfusion model of isolated thoracic aorta rings of rats was applied. The e...
关键词：GASTRODIN thoracic aorta ring VASORELAXATION Chinese medicine 
Brazilin isolated from the heartwood of Caesalpinia sappan L induces endothelium-dependent and -independent relaxation of rat aortic rings被引量：3
《Acta Pharmacologica Sinica》2015年第11期1318-1326,共9页Yu YAN Yu-cai CHEN Yi-huang LIN Jing GUO Zi-ran NIU Li LI Shou-bao WANG Lian-hua FANG Guan-hua DU 
Acknowledgements This study was supported by grants from the National Science and Technology Major Project （No 2013ZX09103-001-008 and 2012ZX09103-101-078） and the National Natural Science Foundation of China （No 81102444 and 81202538）.
Aim： Brazilin is one of the major constituents of Caesalpinia sappan L with various biological activities. This study sought to investigate the vasorelaxant effect of brazilin on isolated rat thoracic aorta and explo...
关键词：BRAZILIN rat aortic rings VASORELAXATION ENDOTHELIUM nitric oxide calcium channels ERK1/2 myosin light chain 
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