BRAZILIN

作品数：9被引量：31H指数：3
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相关领域：医药卫生更多>>
相关作者：张洪彬潘成学关一富李艳羊晓东更多>>
相关机构：云南大学广西师范大学红河学院中国科学院更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《化学学报》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划云南省自然科学基金长江学者和创新团队发展计划更多>>
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Brazilin Actuates Ferroptosis in Breast Cancer Cells via p53/SLC7A11/GPX4 Signaling Pathway
《Chinese Journal of Integrative Medicine》2024年第11期1001-1006,共6页HE Dan TAN Xiao-ning LI Lin-pei GAO Wen-hui TIAN Xue-fei ZENG Pu-hua 
Supported by National Administration of Traditional Chinese Medicine Youth Qihuang Scholars Talent Project,the 73rd Batch of Grant from China Postdoctoral Science Foundation(No.2023M731069);Traditional Chinese Medicine Administration Project of Hunan Province(No.B2023086);Health Research Project of Hunan Provincial Health Commission(No.W20243081)。
Objective:To investigate the mechanism of induction of ferroptosis by brazilin in breast cancer cells.Methods:Breast cancer 4T1 cells were divided into 6 groups:control,brazilin 1/2 half maximal inhibitory concentrati...
关键词：breast cancer BRAZILIN ferroptosis p53/SLC7A11/GPX4 axis Chinese medicine 
Optimization of Caesalpinia sappan L. heartwood extraction procedure to obtain the highest content of brazilin and greatest antibacterial activity被引量：2
《Journal of Integrative Medicine》2019年第5期351-358,共8页Sukanya Settharaksa Chaowalit Monton Laksana Charoenchai 
the Research Institute of Rangsit University for financial support (Grant No. 14/2560)
Objective: The objective of the work was to optimize the extraction conditions of Caesalpinia sappan L.heartwood in order to maximize the brazilin content and antibacterial activity of the extract.Methods: Two indepen...
关键词：ANTIBACTERIAL activity BRAZILIN CAESALPINIA sappan OPTIMIZATION 
Brazilin and Caesalpinia sappan L. extract protect epidermal keratinocytes from oxidative stress by inducing the expression of GPX7被引量：7
《Chinese Journal of Natural Medicines》2018年第3期203-209,共7页Hyung Seo Hwang Joong Hyun Shim 
supported by the Technological Innovation R&D Program(No.S2443581)funded by the Small and Medium Business Administration(SMBA,Korea)
Caesalpinia sappan L., belonging to the family Leguminosae, is a medicinal plant that is distributed in Southeast Asia. The dried heartwood of this plant is used as a traditional ingredient of food, red dyes, and folk...
关键词：Caesalpinia sappan L. BRAZILIN Ultraviolet GPX7 ANTIOXIDATIVE 
Brazilin isolated from the heartwood of Caesalpinia sappan L induces endothelium-dependent and -independent relaxation of rat aortic rings被引量：3
《Acta Pharmacologica Sinica》2015年第11期1318-1326,共9页Yu YAN Yu-cai CHEN Yi-huang LIN Jing GUO Zi-ran NIU Li LI Shou-bao WANG Lian-hua FANG Guan-hua DU 
Acknowledgements This study was supported by grants from the National Science and Technology Major Project （No 2013ZX09103-001-008 and 2012ZX09103-101-078） and the National Natural Science Foundation of China （No 81102444 and 81202538）.
Aim： Brazilin is one of the major constituents of Caesalpinia sappan L with various biological activities. This study sought to investigate the vasorelaxant effect of brazilin on isolated rat thoracic aorta and explo...
关键词：BRAZILIN rat aortic rings VASORELAXATION ENDOTHELIUM nitric oxide calcium channels ERK1/2 myosin light chain 
Brazilin from Caesalpinia sappan heartwood and its pharmacological activities:A review被引量：14
《Asian Pacific Journal of Tropical Medicine》2015年第6期421-430,共10页Nilesh P Nirmal Mithun S Rajput Rangabhatla G.S.V.Prasad Mehraj Ahmad 
Caesalpinia sappan L.(CS) is a plant of Leguminosae family,commonly known as Brazil or Sappan wood.CS is distributed in Southeast Asia and its dried heartwood has been used as traditional ingredient of food or beverag...
关键词：BRAZILIN CAESALPINIA sappan EXTRACTION HEARTWOOD Pharamcological ACTIVITIES 
氮杂Brazilin-咪唑盐杂合物的设计、合成及细胞毒活性研究被引量：5
《有机化学》2015年第6期1276-1285,共10页汪学全 李艳 羊晓东 张洪彬 
长江学者和创新团队发展计划(No.IRT13095);国家自然科学基金(Nos.21462049;21332007;U1402227);云南省自然科学基金(Nos.2013FA028;2012FB113;2010GA014)资助项目~~
从3,4-二甲氧基苯丙酸出发合成了一系列新型的氮杂Brazilin-咪唑盐杂合物,其结构经1H NMR,13C NMR,HR-ESI-MS以及X射线单晶衍射确定.对合成的新化合物进行了体外抗肿瘤活性筛选,发现3-(萘-2-甲基)-1-(2-氧代-2-(4,9,10-三甲氧基-6,6a,7,...
关键词：氮杂Brazilin 咪唑 杂合物 细胞毒活性 
氮杂Brazilin/二芳基茚杂合物的合成研究被引量：3
《有机化学》2012年第6期1116-1120,共5页潘成学 关一富 张洪彬 
国家973重大基础研究计划子项目(No.2009CB522300)资助项目~~
天然产物在药物化学中具有非常重要的地位,天然产物杂合物的设计合成,可以为药物筛选提供数目更多、结构更多样化的生物活性分子,是发现更多的新药先导化合物的一条非常重要的途径.以邻苯二甲醚为原料,经傅克酰基化、酮酯缩合、Knoevena...
关键词：氮杂brazilin 天然产物杂合物 1 3-二芳基茚 合成 
Brazilin类似物的合成被引量：1
《化学学报》2012年第2期183-189,共7页潘成学 关一富 张洪彬 
国家973重大基础研究计划子项目(No.2009CB522300)资助项目~~
以3-(3,4-二甲氧苯基)丙酸为原料,经分子内傅-克反应、双羟基化、Lombardo反应,高价碘的氧化及类Pinacol重排等共10步反应,完成了brazilin类似物的合成.
关键词：BRAZILIN 天然产物类似物 合成 
Brazilin Content, Antioxidative and Lipase Inhibition Effects of Sappanwood （Caesa/pinia Sappan） from Indonesia被引量：1
《Journal of Chemistry and Chemical Engineering》2010年第10期50-55,共6页Irmanida Batubara Mohamad Rafi Siti Sa＇diah M. Agung Zaim Susi lndariani Tohru Mitsunaga 
Determination of brazilin by High Performance Liquid Chromatography （HPLC） method and measurement of the antioxidative and lipase inhibition effects in the Caesalpinia sappan wood from various locations in Indonesia...
关键词：Caesalpinia sappan sappanwood BRAZILIN antioxidant activity lipase inhibition activity HPLC. 
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