Preparation of oximoether derivatives of osthole and their pesticidal properties  

作　　者：Zili Ren Min Lv Yuling Zhang Jiawei Du Hui Xu 

机构地区：[1]College of Plant Protection,Northwest A&F University,Yangling,712100,China

出　　处：《Advanced Agrochem》2023年第2期173-179,共7页现代农业化学（英文）

基　　金：funded by the National Natural Science Foundation of China(Project No.32172453).

摘　　要：To explore non-food bioactive products for pesticide candidates,and high value-added application of crop plants in agriculture,by using osthole(a natural coumarin isolated from a Chinese herbal medicine Cnidium monnieri)as a lead compound,a series of osthole derivatives containing oximoether groups were synthesized,and evaluated for their agricultural activities against Tetranychus cinnabarinus and Mythimna separata.The key steric configurations of eight derivatives were confirmed by X-ray crystallography.Especially compound 4r showed potential insecticidal activity(>2-fold of osthole)against M.separata,and 4g displayed good acaricidal activity against T.cinnabarinus(LC_(50)=0.566 mg/mL,>2-fold of osthole).Their structure-activity relationships were also concluded.It will pave the way for future application of osthole derivatives as coumarin-kind botanical pesticides in crop protection.

关 键 词：OSTHOLE Bioactive product Pesticidal activity Structural modification Control efficiency 

分 类 号：O62[理学—有机化学]