OSTEOBLASTS

作品数：187被引量：718H指数：13
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相关领域：医药卫生更多>>
相关作者：芮泽王德峰范克伟张辉王彤更多>>
相关机构：兰州军区兰州总医院泰山医学院附属医院北京市耳鼻咽喉科研究所福建省泉州市第一医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划河北省自然科学基金中国博士后科学基金更多>>
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Runx2 controls the osteogenic fate of growth plate chondrocytes
《Genes & Diseases》2025年第3期1-3,共3页Daofu Zeng Jiamin Yu Ke Lu Dan Yi Zhidao Xia Ling Qin Guozhi Xiao Xiao Yang Liping Tong Di Chen 
supported by the National Key Research and Development Program of China(No.2022YFA1207500);the National Natural Science Foundation of China(No.82394445 to D.C.and L.T.;82250710174 and 82030067 to D.C.;82161160342 to D.C.and L.Q.);the Shenzhen Science and Technology Research Funding(No.JCYJ20220818101414032 to L.T.;JSGGKQTD20210831174330015 to D.C.).
The origin of bone marrow osteoblasts is not totally understood.Recent findings demonstrated that bone marrow osteoblasts could be derived from a subpopulation of hypertrophic Col2^(+)/Col10^(+)chondrocytes which migr...
关键词：RUNX mesenchymal progenitor cells chondrocyte osteoblast transdifferentiation hypertrophic chondrocytes growth plate bone marrow bone marrow osteoblasts 
Naked cuticle homolog 2 controls the differentiation of osteoblasts and osteoclasts and ameliorates bone loss in ovariectomized mice
《Genes & Diseases》2025年第1期281-297,共17页Liying Shan Xiaoxia Liao Xiaoli Yang Endong Zhu Hairui Yuan Jie Zhou Xiaoxia Li Baoli Wang 
funded by the National Natural Science Foundation of China(No.82072389,82272444,81972033).
Naked cuticle homolog 2(NKD2)has been recognized as an antagonist of Wnt/β-catenin signaling and a tumor suppressor.The role of NKD2 in osteoblast and osteoclast differentiation and the mechanism are not fully unders...
关键词：Mechanistictargetof rapamycincomplex1 Naked cuticle homolog 2 OSTEOBLAST OSTEOCLAST Receptoractivatorof nuclearfactorkB ligand WNT/Β-CATENIN 
DEC1 deficiency protects against bone loss induced by ovariectomy by inhibiting inflammation被引量：1
《Journal of Biomedical Research》2024年第6期613-627,共15页Lan Lin Zhiyi Qiang Kaiao Chen Ying Huo Wei Liu Jian Yang 
supported by the National Natural Science Foundation of China(Grant Nos.82073934 and 81872937 to J.Y.);the Special Foundation for Clinical Science and Technology of Jiangsu Province(Grant No.JX10114120).
Studies have shown that differentiated embryo-chondrocyte expressed gene 1(DEC1)promotes osteoblast osteogenesis.To investigate the role of DEC1 in postmenopausal osteoporosis,we used the two genotypes of mice(Dec1+/+...
关键词：DEC1 postmenopausal osteoporosis ESTROGEN OSTEOBLASTS OSTEOCLASTS 
A review:the mechanism of plant-derived polysaccharides on osteoblasts and osteoclasts
《Journal of Future Foods》2024年第3期183-192,共10页Mengjie Ren Adel F.Ahmed Meng Li Menghan Li Zhiruo Yan Jinmei Wang 
supported by the College students’innovation Project of Henan University(20221020006).
Bone loss and deterioration of bone microarchitecture would increase the bone fragility and fracture risk,leading to the osteoporosis.More and more evidences proved that plant-derived polysaccharides could have a rema...
关键词：Osteoporosis Plant-derived polysaccharides Osteogenesis promotion Osteoclasts inhibition 
The potent osteo-inductive capacity of bioinspired brown seaweed-derived carbohydrate nanofibrous three-dimensional scaffolds
《Marine Life Science & Technology》2024年第3期515-534,共20页Zahra Dadashi Ouranj Saadi Hosseini Atefeh Alipour Shahin Homaeigohar Shahram Azari Leila Ghazizadeh Mohammadali Shokrgozar Sabu Thomas Saeed Irian Hosein Shahsavarani 
This study aimed to investigate the osteo-inductive capacity of a fucoidan polysaccharide network derived from brown algae on human adipose-derived stem cells(HA-MSCs)for bone regeneration.The physiochemical propertie...
关键词：Bone tissue engineering Seaweed-derived scaffold FUCOIDANS HA-MSCs differentiation OSTEOBLASTS 
Responses of osteoblasts under varied tensile stress types induced by stretching basement materials
《International Journal of Smart and Nano Materials》2024年第2期279-295,共17页Xuezheng Geng Qiao Li Yan Yao Lizhen Wang Yubo Fan 
supported by the Beijing Municipal Natural Science Foundation [7212205];National Key Research and Development Program of China [2023YFC2410404];National Natural Science Foundation of China [12172034,U20A20390,11827803];Fundamental Research Funds for the Central Universities;111 project [B13003].
Osteoblasts are mechanosensitive cells.Tensile stress with different conditions,including loading time,frequency,magnitude,etc.would cause varied responses in osteoblasts.However,it was not clarified that the effect o...
关键词：MC3T3-E1 tensile stress negative poisson’s ratio cell proliferation YAP 
Isolation and culture of human primary osteoblasts:Comparing the effects of differences in method details on osteoblast characteristics
《Genes & Diseases》2024年第2期546-549,共4页Fei Chen Yan Zhang Pai Peng Xiao-Ting Huang Zi-Han Qiu Bao-Cheng Liu Tie-Lin Yang Bo Yang Yan Guo 
supported by the National Natural Science Foundation of China(No.82170896,31970569);Science Fund for Distinguished Young Scholars of Shaanxi Province,China(No.2021JC-02);Innovation Capability Support Program of Shaanxi Province,China(No.2022TD-44);China Postdoctoral Science Foundation(No.2021M692582);Natural Science Basic Research Program of Shaanxi Province,China(No.2022JQ-808,2023-YBSF-180);Fundamental Research Funds for the Central Universities(China)(No.xzy012022032).
Osteoblasts are essential in the maintenance of human bone homeostasis.1 The abnormal formation and impaired differentiation ability of osteoblasts are pivotal factors leading to bone-related diseases,suggesting that ...
关键词：IMPAIRED CULTURE DETAILS 
Knocking down AR promotes osteoblasts to recruit prostate cancer cells by altering exosomal circ-DHPS/miR-214-3p/CCL5 pathway被引量：2
《Asian Journal of Andrology》2024年第2期195-204,共10页Zhao Yang Jia-Qi Chen Tian-Jie Liu Yu-Le Chen Zhen-Kun Ma Yi-Zeng Fan Zi-Xi Wang Shan Xu Ke Wang Xin-Yang Wang Lei Li Hong-Jun Xie 
supported by grant from the National Natural Science Foundation of China(No.82002693 and No.81803022);the Natural Science Foundation of Shaanxi Province(No.2022JQ-903 and No.2020JQ-519).
Tumor-derived exosomes have been shown to play a key role in organ-specific metastasis,and the androgen receptor regulates prostate cancer(PCa)progression.It is unclear whether the androgen receptor regulates the recr...
关键词：androgen receptor circRNA EXOSOME prostate cancer 
B-cell lymphoma-2 phosphorylation at Ser70 site-related autophagy mediates puerarin-inhibited the apoptosis of MC3T3-E1 cells during osteoblastogenesis被引量：1
《Journal of Traditional Chinese Medicine》2024年第1期27-34,共8页LI Xi LIN Xiangquan CHEN Dongdong LIU Hui 
Fujian Provincial Natural Science:Exploration of Crisis Warning Values for Intraoperative Electrophysiological Monitoring in High-risk Cervical Spondylosis Patients on the Brink of Paralysis(No.2019J01548);Fujian Provincial Clinical Medical Research Center for First Aid and Rehabilitation in Orthopaedic Trauma:Study on the Treatment of Osteoporosis(No.2020Y2014)。
OBJECTIVE:To explore the relationship between autophagy and apoptosis regulated by puerarin during osteoblastogenesis.METHODS:In this study,the effects of puerarin on the autophagic activity and apoptosis level of ost...
关键词：PUERARIN OSTEOBLASTS AUTOPHAGY APOPTOSIS lymphoma B-CELL 
Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice被引量：3
《Bone Research》2023年第4期772-783,共12页Zhousheng Xiao Li Cao Micholas Dean Smith Hanxuan Li Wei Li Jeremy C.Smith Leigh Darryl Quarles 
supported by National Institutes of Health(NIH),National Institute of Arthritis and Musculoskeletal and Skin Diseases(Grant RO1-AR071930);National Institute of Diabetes and Digestive and Kidney Diseases(Grant RO1 DK121132);supported by the Office of Science of the U.S.Department of Energy under Contract No.DE-AC05-00OR22725。
Molecular mechanisms transducing physical forces in the bone microenvironment to regulate bone mass are poorly understood.Here,we used mouse genetics,mechanical loading,and pharmacological approaches to test the possi...
关键词：MEC IMPAIRED ADDITIVE 
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