Runx2 controls the osteogenic fate of growth plate chondrocytes  

作　　者：Daofu Zeng Jiamin Yu Ke Lu Dan Yi Zhidao Xia Ling Qin Guozhi Xiao Xiao Yang Liping Tong Di Chen 

机构地区：[1]Research Center for Computer-aided Drug Discovery,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong 518055,China [2]Faculty of Pharmaceutical Sciences,Shenzhen University of Advanced Technology,Shenzhen,Guangdong 518055,China [3]University of Chinese Academy of Sciences,Chinese Academy of Sciences,Beijing 100049,China [4]Institute of Life Science,Swansea University Medical School,Swansea,SA28PP,UK [5]Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology and Innovative Orthopaedic Biomaterial&Drug Translational Research Laboratory,Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong,Hong Kong 518172,China [6]School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong 518055,China [7]State Key Laboratory of Proteomics,Genetic Laboratory of Development and Diseases,Institute of Biotechnology,Beijing 100071,China

出　　处：《Genes & Diseases》2025年第3期1-3,共3页基因与疾病(英文)

基　　金：supported by the National Key Research and Development Program of China(No.2022YFA1207500);the National Natural Science Foundation of China(No.82394445 to D.C.and L.T.;82250710174 and 82030067 to D.C.;82161160342 to D.C.and L.Q.);the Shenzhen Science and Technology Research Funding(No.JCYJ20220818101414032 to L.T.;JSGGKQTD20210831174330015 to D.C.).

摘　　要：The origin of bone marrow osteoblasts is not totally understood.Recent findings demonstrated that bone marrow osteoblasts could be derived from a subpopulation of hypertrophic Col2^(+)/Col10^(+)chondrocytes which migrate from the growth plate into the bone marrow cavity underneath the growth plate and dedifferentiate into mesenchymal progenitor cells and then differentiate into mature osteoblasts.1 This process is called chondrocyte-osteoblast transdifferentiation.This type of osteoblast participates in bone formation and is involved in maintaining bone remodeling,especially in the epiphyseal and diaphyseal regions of long bone.Several growth factors,such as Ihh,PTH,and Wnt signaling molecules have been demonstrated to play a critical role in the regulation of chondrocyte-osteoblast transdifferentiation2;however,the role of Runx2,the key transcription factor controlling skeletal development,3 in chondrocyte-osteoblast transdifferentiation has not been fully defined.

关 键 词：RUNX mesenchymal progenitor cells chondrocyte osteoblast transdifferentiation hypertrophic chondrocytes growth plate bone marrow bone marrow osteoblasts 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]