PHARMACOKINETIC

作品数：198被引量：431H指数：10
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相关作者：程远国王艺林玮玮肇丽梅丁俊杰更多>>
相关机构：山东大学河北医科大学首都医科大学附属北京天坛医院军事医学科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金河北省自然科学基金更多>>
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Synthesis of a novel pharmaceutical excipient: An anion exchange resin
《Journal of Chinese Pharmaceutical Sciences》2025年第2期109-125,共17页Zhannuan Yin Xianghuan Meng Yingshu Feng Ke Li Xinyi Tang Hongfei Liu Haibing He Wei Mi 
2023 Nantong Jianghai Talents Project,the Nantong Social Livelihood Science and Technology Plan for 2023;the 2022 New Drugs and Platform Enhancement Project of the Yangtze Delta Drug Advanced Research Institute.Additionally,support was p rovided by the Zhenjiang Science and Technology Project(Grant No.SH2020048);the China Postdoctoral Science Foundation(Grant No.2020M681532);the Jiangsu Planned Projects for Postdoctoral Research Funds(Grant No.2020Z209);the Natural Science Research Projects of Universities in Jiangsu Province(Grant No.20KJD350001).
The aim of this study was to develop a novel pharmaceutical excipient:an anion exchange resin.Initially,polystyrenedivinylbenzene(PS-DVB)microspheres were synthesized via suspension polymerization.Subsequently,these m...
关键词：Suspension polymerization reaction POLYSTYRENE-DIVINYLBENZENE Quaternarization reaction Anion exchange resin Fluidized bed coating method Pharmacokinetic research 
Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study
《World Journal of Gastroenterology》2025年第2期102-112,共11页Thanaboon Chaemsupaphan Aviv Pudipeddi Hui-Yu Lin Sudarshan Paramsothy Viraj C Kariyawasam Melissa Kermeen Rupert W Leong 
Supported by Takeda Australia,No.IISR-2016-101883.
BACKGROUND Ulcerative colitis(UC)is a chronic inflammatory condition requiring continuous treatment and monitoring.There is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thio...
关键词：PHARMACOKINETIC Vedolizumab THIOPURINE Ulcerative colitis Trough concentration Antibody Inflammatory bowel diseases 
Biopharmaceutical and pharmacokinetic attributes to drive nanoformulations of small molecule tyrosine kinase inhibitors
《Asian Journal of Pharmaceutical Sciences》2024年第6期48-83,共36页Soumyadip Mukherjee Vedant Joshi Kolimi Prashanth Reddy Nidhi Singh Priyanka Das Pallab Datta 
Buoyed by the discovery of small-molecule tyrosine kinase inhibitors(smTKIs),significant impact has been made in cancer chemotherapeutics.However,some of these agents still encounter off-target toxicities and suboptim...
关键词：PHARMACOKINETICS Tyrosine kinase inhibitors NANOPARTICLES Liposomes Peak plasma concentration 
Metformin—Pharmacokinetic and Pharmacodynamics Journey Through the Body
《Pharmacology & Pharmacy》2024年第12期466-477,共12页Alycia Lewis Kelley Williams Terry Oroszi 
Metformin is a commonly prescribed drug used to treat type 2 diabetes. The drug works by decreasing the amount of glucose the liver produces, increasing the sensitivity of muscle cells to insulin, and delaying the abs...
关键词：DIABETES METFORMIN PHARMACOKINETIC PHARMACODYNAMIC Personalized Medicine 
Bioequivalence of Two Formulations of Metformin Hydrochloride 1000 mg XR Tablets, Fasting Condition in Healthy Adults Subjects
《Journal of Biosciences and Medicines》2024年第12期411-423,共13页Evelyn Pena Alfredo Inatti Anyoly Taly José Chacón Xenon Serrano-Martin 
Background: This study aimed to evaluate the bioequivalence of the two formulations of metformin 1000 mg XR tablets in healthy male volunteers under fasting conditions. Methods: This was a randomized, single-dose, ope...
关键词：BIOEQUIVALENCE METFORMIN PHARMACOKINETIC 
A Bioequivalence Study of Empagliflozin/Metformin Fixed-Dose Combination in Healthy Subjects under Fasting Conditions
《Journal of Biosciences and Medicines》2024年第9期235-250,共16页Evelyn Pena Alfredo Inatti Anyoly Taly José Chacón Xenon Serrano-Martin 
Background: This study evaluated the bioequivalence of empagliflozin 12.5 mg/metformin 1000 mg tablets compared to Synjardy® (Empagliflozin 12.5 mg/metformin 1000 mg) tablets in healthy male subjects under fasting con...
关键词：BIOEQUIVALENCE Fix Dose Combinations PHARMACOKINETIC Empagliflozin 
Subcutaneous daratumumab in Chinese patients with relapsed or refractory multiple myeloma:an open-label,multicenter,phase 1 study(MMY1010)
《Blood Science》2024年第3期42-47,共6页Gang An Zheng Ge Hongmei Jing Jing Liu Guoping Yang Ru Feng Zhongyuan Xu Ming Qi Jianping Wang Juanjuan Song Wei Zhou Binbin Sun Dian Zhu Xi Chen Canchan Cui Lugui Qiu 
Despite recent progress in multiple myeloma(MM)treatments,most patients will relapse and require additional treatment.Intravenous daratumumab,a human IgGκmonoclonal antibody targeting CD38,has shown good efficacy in ...
关键词：Chinese Daratumumab Multiple myeloma PHARMACOKINETIC Relapse/refractory Safety SUBCUTANEOUS 
Pharmacokinetic Comparison and Bioequivalence Evaluation of Two 20-mg Vonoprazan Fumarate Tablets in Bangladeshi Healthy Male Subjects
《Journal of Biosciences and Medicines》2024年第8期230-243,共14页Md. Alimur Reza Uttom Kumar Bhowmik Sabrina Akter Tushi Nayan Ghosh Nithon Chandra Sahana Md. Ashraful Islam Nafisa Ahamed Arifa Akram 
Background: Vonoprazan fumarate, a novel potassium-competitive acid blocker, outperforms traditional proton pump inhibitors in acid suppression and can be effectively combined with antibiotics to eradicate Helicobacte...
关键词：BIOEQUIVALENCE Vonoprazan Pharmacokinetics 
Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK-STAT pathway
《Acta Pharmaceutica Sinica B》2024年第6期2554-2566,共13页Jingyi Tan Jiayu Zhang Cheng Hu Gongwei Wang Qianyao Ren Chaoqun Wang Jia Dan Zexin Zeng Jun Hu Wenbo Zhu Jiankai Liang Jing Cai Ying Liu Guangmei Yan Yuan Lin 
supported by National Key R&D Program of China(No.2021YFA0909800,China);Guangdong Basic and Applied Basic Research Foundation(Nos.2022B1515020056,2021A1515011881,2023A1515010737,China);Leading team for entrepreneurship in Guangzhou,Guangdong Province(No.201809020004,China);Fundamental Research Funds for the Central Universities(No.22ykqb12,China);Pioneering talents project of Guangzhou Development Zone,Guangdong Province(2020-L036,China);Natural Science Foundation of Guangdong Province(No.2022A1515011056,China).
Oncolytic viruses(OVs),a group of replication-competent viruses that can selectively infect and kill cancer cells while leaving healthy cells intact,are emerging as promising living anticancer agents.Unlike traditiona...
关键词：PHARMACOKINETICS Oncolytic virus JAK-STAT ANTICANCER 
Insulin therapy in type 2 diabetes: Insights into clinical efficacy, patient-reported outcomes, and adherence challenges
《World Journal of Diabetes》2024年第5期828-852,共25页Mahmoud Emad-Eldin Gehan F Balata Eman A Elshorbagy Mona S Hamed Mohamed S Attia 
Insulin therapy plays a crucial role in the management of type 2 diabetes as the disease progresses.Over the past century,insulin formulations have undergone significant modifications and bioengineering,resulting in a...
关键词：ADHERENCE DIABETES INSULIN Patient-reported outcomes PHARMACOKINETIC PHARMACODYNAMIC 
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