THIOPURINE

作品数：18被引量：28H指数：4
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相关期刊：《World Journal of Gastroenterology》《International Journal of Dermatology and Venereology》《World Journal of Gastrointestinal Surgery》《世界最新医学信息文摘》更多>>
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Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study
《World Journal of Gastroenterology》2025年第2期102-112,共11页Thanaboon Chaemsupaphan Aviv Pudipeddi Hui-Yu Lin Sudarshan Paramsothy Viraj C Kariyawasam Melissa Kermeen Rupert W Leong 
Supported by Takeda Australia,No.IISR-2016-101883.
BACKGROUND Ulcerative colitis(UC)is a chronic inflammatory condition requiring continuous treatment and monitoring.There is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thio...
关键词：PHARMACOKINETIC Vedolizumab THIOPURINE Ulcerative colitis Trough concentration Antibody Inflammatory bowel diseases 
Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers
《World Journal of Gastroenterology》2024年第12期1751-1763,共13页Ting Yang Kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan Yan-Ping Guan Jing Mao Pan Li Shao-Xing Guan Wen Xie Xiang Gao Min Huang 
Supported by the National Natural Science Foundation of China,No.82020108031,No.81973398,and No.82104290;Guangdong Provincial Key Laboratory of Construction Foundation,No.2020B1212060034;Guangdong Basic and Applied Basic Research Foundation,No.2022A1515012549 and No.2023A1515012667.
BACKGROUND Thiopurine-induced leucopenia significantly hinders the wide application of thiopurines.Dose optimization guided by nudix hydrolase 15(NUDT15)has significantly reduced the early leucopenia rate,but there ar...
关键词：Thiopurine-induced late leucopenia DNA-thioguanine 6-thioguanine nucleotide Proactive therapeutic drug monitoring Crohn’s disease 
Anagen Effluvium due to Azathioprine in a Patient With Normal Thiopurine S-Methyltransferase Levels:A Case Report Using Videodermoscopic Analysis
《International Journal of Dermatology and Venereology》2023年第4期239-240,共2页Swapnil Shah Balachandra S.Ankad Tanuja Rajagopal 
Introduction:Anagen effluvium (AE) is caused by impaired mitotic activity of matrix cells in the hair follicles.It presents with sudden loss of hair and myelosuppression.The diagnosis is based on the clinical history,...
关键词：trichoscopy videodermoscopy anagen effluvium thiopurineS-methyltransferase case report 
Biomarkers for gastrointestinal adverse events related to thiopurine therapy
《World Journal of Gastroenterology》2021年第38期6348-6356,共9页Giulia Zudeh Raffaella Franca Gabriele Stocco Giuliana Decorti 
Thiopurines are immunomodulators used in the treatment of acute lymphoblastic leukemia and inflammatory bowel diseases.Adverse reactions to these agents are one of the main causes of treatment discontinuation or inter...
关键词：THIOPURINES Gastrointestinal adverse effects Biomarkers PACSIN2 RAC1 ITPA 
Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients被引量：4
《World Journal of Gastroenterology》2019年第38期5850-5861,共12页Xia Zhu Kang Chao Miao Li Wen Xie Hong Zheng Jin-Xin Zhang Pin-Jin Hu Min Huang Xiang Gao Xue-Ding Wang 
Supported by the National Natural Science Foundation of China,No.81573507,No.81473283,No.81173131,and No.81320108027;Guangdong Provincial Key Laboratory Construction Foundation,No.2017B030314030;The National Key Research and Development Program,No.2016YFC0905003;the 111 Project,No.B16047
BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants signif...
关键词：Crohn’s disease Thioguanine NUCLEOTIDE levels NUCLEOSIDE diphosphatelinked MOIETY X-type MOTIF 15 Thiopurine-induced LEUKOPENIA 
Thiopurine use associated with reduced B and natural killer cells in inflammatory bowel disease被引量：1
《World Journal of Gastroenterology》2017年第18期3240-3251,共12页James D Lord Donna M Shows 
Supported by Virginia Mason Medical Center,Digestive Disease Institute Research Grant Award,No.0506812-2011
To identify which blood and mucosal lymphocyte populations are specifically depleted by thiopurine use in vivo.METHODSThe thiopurines azathioprine and 6-mercaptopurine have been a mainstay of inflammatory bowel diseas...
关键词：THIOPURINE AZATHIOPRINE MERCAPTOPURINE LYMPHOCYTE Natural killer cell Transitional B cell Inflammatory bowel disease 
Hepatosplenic T-cell lymphoma in a 47-year-old Crohn's disease patient on thiopurine monotherapy
《World Journal of Gastroenterology》2016年第47期10465-10470,共6页Maartje M van de Meeberg Lauranne AAP Derikx Harm AM Sinnige Peet Nooijen D Lucette Schipper Loes HC Nissen 
Hepatosplenic T-cell lymphoma(HSTCL) is a rare nonHodgkin lymphoma with a high mortality rate. Higher incidence is reported in patients with inflammatory bowel disease, specifically in male patients that are younger t...
关键词：Hepatosplenic T-cell lymphoma THIOPURINE Crohn’s disease IMMUNOSUPPRESSION 
Impact of thiopurines and anti-tumour necrosis factor therapy on hospitalisation and long-term surgical outcomes in ulcerative colitis被引量：1
《World Journal of Gastrointestinal Surgery》2015年第12期360-369,共10页Christopher Alexakis Richard CG Pollok 
Ulcerative colitis(UC) is a chronic inflammatory condition affecting the large bowel and is associated with a significant risk of both requirement for surgeryand the need for hospitalisation. Thiopurines, and more rec...
关键词：IMMUNOMODULATOR AZATHIOPRINE Antitumournecrosis factor THIOPURINE Ulcerative colitis HOSPITALISATION Surgery COLECTOMY Admission 
Clinical predictors of thiopurine-related adverse events in Crohn's disease被引量：2
《World Journal of Gastroenterology》2015年第25期7795-7804,共10页Gordon W Moran Marie-France Dubeau Gilaad G Kaplan Hong Yang Bertus Eksteen Subrata Ghosh Remo Panaccione 
the Alberta Inflammatory Bowel Disease Consortium and the Alberta Innovates Health Solutions for funding support for this project
AIM: To determine the incidence and predictors of thiopurine-related adverse events. METHODS: Subjects with Crohn's disease who were followed in the Alberta Inflammatory Bowel Disease Consortium patient database regis...
关键词：THIOPURINES AZATHIOPRINE MERCAPTOPURINE ADVERSE EVENTS 
Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease:Effect of N-acetyl transferase polymorphisms被引量：5
《World Journal of Gastroenterology》2015年第12期3571-3578,共8页Gabriele Stocco Eva Cuzzoni Sara De Iudicibus Diego Favretto Noelia Malusà Stefano Martelossi Elena Pozzi Paolo Lionetti Alessandro Ventura Giuliana Decorti 
Supported by Italian Ministry of Health,and Fondazione Benefica Alberto e Kathleen Casali
AIM: To evaluate variation of the concentration of thiopurine metabolites after 5-aminosalicylate(5-ASA) interruption and the role of genetic polymorphisms of N-acetyl transferase(NAT) 1 and 2. METHODS: Concentrations...
关键词：THIOPURINES AMINOSALICYLATES Inflammatory BOWEL di 
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