Introduction:Anagen effluvium (AE) is caused by impaired mitotic activity of matrix cells in the hair follicles.It presents with sudden loss of hair and myelosuppression.The diagnosis is based on the clinical history,...
BACKGROUND There is no consensus on the recommended duration of and optimal time to stop azathioprine(AZA)therapy in inflammatory bowel disease(IBD).Determining the optimal duration and cessation time can help to bala...
The present study was supported by the National Natural Science Foundation of China(No.81170671);Shanghai Health and Family Planning Committee Hundred Talents Program(No.2018BR37).
This study aimed to evaluate the efficacy and safety of mycophenolate mofetil(MMF)or tacrolimus(TAC)compared with azathioprine(AZA)as maintenance therapy for active lupus nephritis(ALN).Patients with ALN who responded...
Azathioprine(AZA)is commonly used as immunosuppressive therapy for autoimmune diseases,including systemic lupus erythematosus(SLE).Myelosuppression is a common side effect of AZA.Here we report a case of severe myelos...
Immunomodulators,particularly the thiopurines and to a lesser extent methotrexate,were standard of care for inflammatory bowel diseases,including Crohn’s disease and ulcerative colitis,for>40 years.While there has be...
BACKGROUND Azathioprine(AZA)and its close analog 6-mercaptopurine are thiopurines widely used in the treatment of patients with cancer,organ transplantation,and autoimmune or inflammatory diseases,including systemic l...
Supported by The Soonchunhyang University Research Fund,No.20200037.
BACKGROUND Autoimmune hepatitis can cause liver fibrosis,liver cirrhosis,and hepatocellular carcinoma.Its treatment option include the use of steroids and/or immunesuppressive agents such as azathioprine.However,these...
supported by National Natural Science Foundation of China[Grant No.81670497,81770545].
Background:NUDT15 R139C is an Asian-prevalent genetic variant related to azathioprine(AZA)intolerance in patients with inflammatory bowel disease(IBD).However,it remains unclear how to utilize the genotyping results t...
Introduction Eccrine spiradenoma(ES)is a rare benign adnexal tumor originating from the eccrine glands that was first described by Kersting and Helwig in 1956.1 ES typically presents as a single,solid,well-defined nod...