IMMUNOMODULATORS

作品数：35被引量：87H指数：5
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Phytochemical analysis of Tinospora cordifolia and Withania somnifera and their therapeutic activities with special reference to COVID-19
《World Journal of Experimental Medicine》2024年第3期39-47,共9页Prateek Rai Tanya Garain Deepshikha Gupta 
Various important medicines make use of secondary metabolites that are produced by plants.Medicinal plants,such as Withania somnifera and Tinospora cordifolia,are rich sources of chemically active compounds and are re...
关键词：Phytochemical analysis Tinospora cordifolia Withania somnifera COVID-19 IMMUNOMODULATORS Giloy ASHWAGANDHA 
Back to the drawing board:Overview of the next generation of combination therapy for inflammatory bowel disease被引量：5
《World Journal of Gastroenterology》2024年第25期3182-3184,共3页Jeffrey A Lowell Michael J Farber Keith Sultan 
Inflammatory bowel disease(IBD)is entering a potentially new era of combined therapeutics.Triantafillidis et al provide an insightful review of the current state of combination therapy,with a focus on the use of a com...
关键词：Inflammatory bowel disease BIOLOGICS IMMUNOMODULATORS Dual-therapy Combination therapy 
Nanoparticle delivery for central nervous system diseases and its clinical application
《Nano Research》2024年第7期6305-6322,共18页Lin Tang Rui Zhang Yusi Wang Mohan Liu Die Hu Yuanda Wang Li Yang 
supported by the National Natural Science Foundation of China(Nos.82073366 and 32100748);the 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD18007);the National Natural Science Foundation of Sichuan Province(No.2022NSFSC1642).
In the treatment of central nervous system(CNS)diseases such as glioma,Alzheimer's disease(AD)and Parkinson's disease(PD),drugs are expected to reach specific areas of the brain to achieve the desired effect.Although ...
关键词：NANOPARTICLES central nervous system(CNS)diseases clinical applications delivery carriers IMMUNOMODULATORS 
Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators
《World Journal of Stem Cells》2024年第6期670-689,共20页Ying Gao Mei-Fang Liu Yang Li Xi Liu Yu-Jie Cao Qian-Fa Long Jun Yu Jian-Ying Li 
Supported by Xi’an Science and Technology Plan Project,No.20200001YX001(1);Xi’an Talent Plan-Elite(Innovative Talents)Project,No.XAYC210062.
BACKGROUND Pulmonary fibrosis(PF)is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation,causing structural damage and lung failure.Stem cell therapy and mes...
关键词：Mesenchymal stem cells Extracellular vesicles Pulmonary fibrosis Oxidative stress response Epithelial-mesenchymal transition 
Risk of hepatitis B virus reactivation in cancer patients undergoing treatment with tyrosine kinase-inhibitors
《World Journal of Gastroenterology》2024年第24期3052-3058,共7页Bansi P Savaliya Ramin Shekouhi Fatima Mubarak Harsheen K Manaise Paola Berrios Jimenez Gabrielle Kowkabany Reed A Popp Kyle Popp Emmanuel Gabriel 
This editorial commented on an article in the World Journal of Gastroenterology titled“Risks of Reactivation of Hepatitis B Virus in Oncological Patients Using Tyrosine Kinase-Inhibitors:Case Report and Literature An...
关键词：Hepatitis B virus REACTIVATION Chronic hepatitis B Tyrosine-kinase inhibitor IMMUNOMODULATORS IMMUNOSUPPRESSANT Nucleoside analogue Hemato-oncology 
TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways
《Hepatobiliary & Pancreatic Diseases International》2024年第2期195-209,共15页Yan Zhang Zhen-Zhen Wang An-Qi Han Ming-Ya Yang Li-Xin Zhu Fa-Ming Pan Yong Wang 
This work was supported by grants from the National Natural Science Foundation of China(52072005 and 51872279).
Background:As reported,γ-tubulin(TuBG1)is related to the occurrence and development of various types of malignant tumors.However,its role in hepatocellular cancer(HCC)is not clear.The present study was to investigate...
关键词：TuBG1 Hepatocellular carcinoma APOPTOSIS Cell cycling IMMUNOMODULATORS 
Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B:A comprehensive review of phases II and III therapeutic agents
《World Journal of Hepatology》2024年第3期331-343,共13页Robert Lam Joseph K Lim 
Chronic hepatitis B virus(HBV)infection affects over 295 million people globally and an estimated 1.6 million people in the United States.It is associated with significant morbidity and mortality due to cirrhosis,live...
关键词：Hepatitis B virus Treatment Clinical trials RNA interference Entry inhibitors Core inhibitors IMMUNOMODULATORS 
De Novo Design and Synthesis of Polypeptide Immunomodulators for Resetting Macrophage Polarization
《BioDesign Research》2023年第1期37-48,共12页Na Kong Hongru Ma Zhongji Pu Fengju Wan Dongfang Li Lei Huang Jiazhang Lian Xingxu Huang Shengjie Ling Haoran Yu Yuan Yao 
the National Natural Science Foundation of China(nos.32071347,51973116,21935002,and 52003156);ZJU-Hangzhou Global Scientific and Technological Innovation Center,Zhejiang University(02020200-K02013008);the China Postdoctoral Science Foundation(2020M681344);joint laboratory grant from Jiangsu Wuzhong Aesthetics Biotech Co.Ltd;and the starting grant of ShanghaiTech University.Materials were tested at Analytical Instrumentation Center(#SPST-AIC10112914)and the Center for High-Resolution Electron Microscopy(CћEM),SPST,ShanghaiTech University.
Modulating the extracellular matrix microenvironment is critical for achieving the desired macrophage phenotype in immune investigations or tumor therapy.Combining de novo protein design and biosynthesis techniques,he...
关键词：MODULATOR POLARIZATION PRECISE 
Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity被引量：1
《Acta Pharmaceutica Sinica B》2023年第9期3930-3944,共15页Xin Tang Chuanxi Wang Lei Wang Feifei Ren Runqiao Kuang Zhenhua Li Xue Han Yiming Chen Guodong Chen Xiuqing Wu Jie Liu Hengwen Yang Xingzhong Liu Chen Wang Hao Gao Zhinan Yin 
supported by the National Key Research and Development Program of China(2018YFA0903200,2018YFA0903201,and 2020YFA0803502);the National Natural Science Foundation of China(81925037,U22A20371,31830021,32030036,and 82270055);the 111 Project(B16021,China);National High-level Personnel of Special Support Program(2017RA2259,China);Guangdong International Science and Technology Cooperation Base(2021A0505020015,China);Innovative and Research Teams Project of Guangdong Higher Education Institution(2021KCXTD001,China);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036,China);Guangdong Natural Science Funds for Distinguished Young Scholar(2021B1515020065,China)。
Interleukin(IL)-17A,a pro-inflammatory cytokine,is a fundamental function in the onset and advancement of multiple immune diseases.To uncover the primary compounds with IL-17A inhibitory activity,a large-scale screeni...
关键词：Aureane-type sesquiterpene tetraketides IL-17A Experimental autoimmune encephalomyelitis Pulmonary hypertension 
Small molecule-based immunomodulators for cancer therapy被引量：10
《Acta Pharmaceutica Sinica B》2022年第12期4287-4308,共22页Yinrong Wu Zichao Yang Kui Cheng Huichang Bi Jianjun Chen 
This work was supported by the National Natural Science Foundation of China(No.82173668);Scientific Research Project of High-Level Talents(No.C1034335,China)in Southern Medical University of China;Thousand Youth Talents Program(No.C1080094,China)from the Organization Department of the CPC Central Committee,China.
Immunotherapy has led to a paradigm shift in the treatment of cancer.Current cancer immunotherapies are mostly antibody-based,thus possessing advantages in regard to pharmacodynamics(e.g.,specificity and efficacy).How...
关键词：Cancer immunotherapy Small molecules IMMUNOMODULATORS INHIBITORS AGONISTS 
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