云南高校图书馆联盟文献共享服务平台- THIOPURINES

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Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study: 《World Journal of Gastroenterology》2025年第2期102-112,共11页Thanaboon Chaemsupaphan Aviv Pudipeddi Hui-Yu Lin Sudarshan Paramsothy Viraj C Kariyawasam Melissa Kermeen Rupert W Leong; Supported by Takeda Australia,No.IISR-2016-101883.; BACKGROUND Ulcerative colitis(UC)is a chronic inflammatory condition requiring continuous treatment and monitoring.There is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thio...; 关键词：PHARMACOKINETIC Vedolizumab THIOPURINE Ulcerative colitis Trough concentration Antibody Inflammatory bowel diseases

Thiopurines are an independent risk factor for active tuberculosis in inflammatory bowel disease patients: 《World Journal of Gastroenterology》2023年第9期1536-1538,共3页Flora Maria Lorenzo Fortes Raquel Rocha Genoile Oliveira Santana; The use of thiopurines is an independent risk factor for active tuberculosis in patients with inflammatory bowel disease.; 关键词：TUBERCULOSIS Inflammatory bowel disease THIOPURINES THERAPY RISK

Solid extraintestinal malignancies in patients with inflammatory bowel disease被引量：2: 《World Journal of Gastrointestinal Oncology》2021年第12期1956-1980,共25页Anastasia Mala Kalliopi Foteinogiannopoulou Ioannis E Koutroubakis; Malignancies constitute the second cause of death in patients with inflammatory bowel diseases(IBD),after cardiovascular diseases.Although it has been postulated that IBD patients are at greater risk of colorectal can...; 关键词：Extraintestinal malignancies Crohn’s disease Ulcerative colitis THIOPURINES Anti-tumor necrosis factor

Biomarkers for gastrointestinal adverse events related to thiopurine therapy: 《World Journal of Gastroenterology》2021年第38期6348-6356,共9页Giulia Zudeh Raffaella Franca Gabriele Stocco Giuliana Decorti; Thiopurines are immunomodulators used in the treatment of acute lymphoblastic leukemia and inflammatory bowel diseases.Adverse reactions to these agents are one of the main causes of treatment discontinuation or inter...; 关键词：THIOPURINES Gastrointestinal adverse effects Biomarkers PACSIN2 RAC1 ITPA

Induced pluripotent stem cells as an innovative model to study drug induced pancreatitis: 《World Journal of Gastroenterology》2021年第35期5796-5802,共7页Elena Genova Gabriele Stocco Giuliana Decorti; Supported by Italian Ministry of Health(IRCCS Burlo Garofolo),No.RC 7_2014.; Drug-induced pancreatitis is a gastrointestinal adverse effect concerning about 2%of drugs.The majority of cases are mild to moderate but severe episodes can also occur,leading to hospitalization or even death.Unfortu...; 关键词：Induced pluripotent stem cells Therapy personalization Patient-specific cells Drug-induced pancreatitis THIOPURINES Inflammatory bowel disease

Mucosa-associated lymphoid tissue lymphoma simulating Crohn’s disease:A case report: 《World Journal of Clinical Cases》2020年第8期1454-1462,共9页Ieva Stundiene Vaidota Maksimaityte Valentina Liakina Jonas Valantinas; BACKGROUND Differential diagnosis between extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue and inflammatory bowel disease is mainly based on histopathologic evaluation of intestinal biopsies,altho...; 关键词：CROHN disease Mucosa-associated LYMPHOID tissue LYMPHOMA RARE diagnosis GASTROINTESTINAL diseases THIOPURINES Case report

Pharmacogenetics of thiopurines: 《Cancer Drug Resistance》2019年第2期256-270,共15页Raffaella Franca Giulia Zudeh Sofia Pagarin Marco Rabusin Marianna Lucafò Gabriele Stocco Giuliana Decorti; This project is supported by the Italian Ministry of Health(Progetto Ricerca Corrente 5/2012).; Polychemotherapeutic protocols for the treatment of pediatric acute lymphoblastic leukemia(ALL)always include thiopurines.Specific approaches vary in terms of drugs,dosages and combinations.Such therapeutic schemes,in...; 关键词：THIOPURINES acute lymphoblastic leukemia therapy personalization thiopurine methyltransferase NUDT15 PACSIN2 inosine triphosphate pyrophosphatase pharmacogenetics clinical implementation

Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn's disease被引量：1: 《World Journal of Gastroenterology》2018年第18期2036-2046,共11页Neera Gupta Robert H Lustig Cewin Chao Eric Vittinghoff Howard Andrews Cheng-Shiun Leu; Supported by National Institutes of Health,No.DK077734(NG);Children’s Digestive Health and Nutrition Foundation(now known as North American Society for Pediatric Gastroenterology,Hepatology,and Nutrition Foundation)/Crohn’s and Colitis Foundation of America(now known as Crohn’s and Colitis Foundation)Award for New Investigators,No.CDHNF-06-002(NG);Crohn’s and Colitis Foundation of America(now known as Crohn’s and Colitis Foundation)Career Development Award,No.Award ID 1743(NG);University of California San Francisco Department of Pediatrics Pediatric Clinical Research Center Clinical Research Pilot Funding Award(NG);National Institutes of Health/National Center for Research Resources University of California San Francisco-Clinical and Translational Science Institute,No.UL1 RR024131; AIM To determine the distribution of anthropometric parameter(AP)-z-scores and characterize associations between medications/serum biomarkers and AP-z-scores in pediatric Crohn's disease(CD).METHODS CD patients [< chr...; 关键词：Inflammatory BOWEL disease Azathioprine/6-mercaptopurine BIOLOGICS Nutrition

Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines被引量：3: 《World Journal of Gastroenterology》2018年第4期511-518,共8页Yuichiro Kojima Yosuke Hirotsu Wataru Omata Makoto Sugimori Shinya Takaoka Hiroshi Ashizawa Keiko Nakagomi Dai Yoshimura Kenji Hosoda Yoji Suzuki Hitoshi Mochizuki Masao Omata; AIM The single nucleotide polymorphism(SNP) c.415C>T in exon 3 of NUDT15 affects thiopurine-induced leukopenia in Asian patients with Crohn's disease. Meanwhile, three additional genetic variants of NUDT15 were report...; 关键词：Inflammatory BOWEL disease NUDT15 LEUKOPENIA Mean corpuscular volume Japanese

Impact of inflammatory bowel disease activity and thiopurine therapy on birth weight: A meta-analysis被引量：3: 《World Journal of Gastroenterology》2017年第45期8082-8089,共8页Begona Gonzalez-Suarez Shreyashee Sengupta Alan C Moss; AIM To investigate the effect of disease activity or thiopurine use on low birth weight and small for gestational age in women with inflammatory bowel disease(IBD).METHODS Selection criteria included all relevant arti...; 关键词：PREGNANCY Inflammatory bowel disease THIOPURINES Disease activity Low birth weight Small for gestational age

THIOPURINES