Induced pluripotent stem cells as an innovative model to study drug induced pancreatitis  

作　　者：Elena Genova Gabriele Stocco Giuliana Decorti 

机构地区：[1]Institute for Maternal and Child Health,IRCCS Burlo Garofolo,Trieste 34137,Italy [2]Department of Life Sciences,University of Trieste,Trieste 34127,Italy [3]Department of Medical,Surgical and Health Sciences,University of Trieste,Trieste 34127,Italy

出　　处：《World Journal of Gastroenterology》2021年第35期5796-5802,共7页世界胃肠病学杂志（英文版）

基　　金：Supported by Italian Ministry of Health(IRCCS Burlo Garofolo),No.RC 7_2014.

摘　　要：Drug-induced pancreatitis is a gastrointestinal adverse effect concerning about 2%of drugs.The majority of cases are mild to moderate but severe episodes can also occur,leading to hospitalization or even death.Unfortunately,the mechanisms of this adverse reaction are still not clear,hindering its prevention,and the majority of data available of this potentially life-threatening adverse effect are limited to case reports leading to a probable underestimation of this event.In particular,in this editorial,special attention is given to thiopurine-induced pancreatitis(TIP),an idiosyncratic adverse reaction affecting around 5%of inflammatory bowel disease(IBD)patients taking thiopurines as immunosuppressants,with a higher incidence in the pediatric population.Validated biomarkers are not available to assist clinicians in the prevention of TIP,also because of the inaccessibility of the pancreatic tissue,which limits the possibility to perform dedicated cellular and molecular studies.In this regard,induced pluripotent stem cells(iPSCs)and the exocrine pancreatic differentiated counterpart could be a great tool to investigate the cellular and molecular mechanisms underlying the development of this undesirable event.This particular type of stem cells is obtained by reprogramming adult cells,including fibroblasts and leukocytes,with a set of transcription factors known as the Yamanaka’s factors.Maintaining unaltered the donors’genetic heritage,iPSCs represent an innovative model to study the mechanisms of adverse drug reactions in individual patients’tissues not easily obtainable from human probands.Indeed,iPSCs can differentiate under adequate stimuli into almost any somatic lineage,opening a new world of opportunities for researchers.Several works are already available in the literature studying liver,central nervous system and cardiac cells derived from iPSCs and adverse drug effects.However,to our knowledge no studies have been performed on exocrine pancreas differentiated from iPSCs and drug-induced pancreatitis,

关 键 词：Induced pluripotent stem cells Therapy personalization Patient-specific cells Drug-induced pancreatitis THIOPURINES Inflammatory bowel disease 

分 类 号：R576[医药卫生—消化系统]