LYMPHOID

作品数:176被引量:485H指数:11
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Comparative analysis of tertiary lymphoid structures for predicting survival of colorectal cancer: a whole-slide images-based study
《Precision Clinical Medicine》2024年第4期318-328,共11页Ming He Huifen Ye Liu Liu Su Yao Zhenhui Li Xinjuan Fan Lili Feng Tong Tong Yanfen Cui Xiaotang Yang Xiaomei Wu Yun Mao Ke Zhao Zaiyi Liu 
supported by the National Science Fund for Distinguished Young Scholars of China(Grant No.81925023);Joint Funds of the National Natural Science Foundation of China(Grant No.U23A20478);the National Science Foundation for Young Scientists of China(Grant No.82202267,82101996).
Background:Tertiary lymphoid structures(TLS)are major components in the immune microenvironment,correlating with a favorable prognosis in colorectal cancer.However,the methods used to define and characterize TLS were ...
关键词:colorectal cancer tertiary lymphoid structures digital pathology prognosis immune 
Tertiary lymphoid structures in diseases:immune mechanisms and therapeutic advances
《Signal Transduction and Targeted Therapy》2024年第9期3942-3984,共43页Lianyu Zhao Song Jin Shengyao Wang Zhe Zhang Xuan Wang Zhanwei Chen Xiaohui Wang Shengyun Huang Dongsheng Zhang Haiwei Wu 
supported by Natural Science Foundation of Shandong Province,China(Grant no.ZR2021MH353);Health Science and Technology Team Building Project of Shandong Province.
Tertiary lymphoid structures(TLSs)are defined as lymphoid aggregates formed in non-hematopoietic organs under pathological conditions.Similar to secondary lymphoid organs(SLOs),the formation of TLSs relies on the inte...
关键词:LYMPHOID THERAPEUTIC DISEASES 
Tissue-specific features of innate lymphoid cells in antiviral defense被引量:2
《Cellular & Molecular Immunology》2024年第9期1036-1050,共15页Sytse J.Piersma 
Innate lymphocytes(ILCs)rapidly respond to and protect against invading pathogens and cancer.ILCs include natural killer(NK)cells,ILC1s,ILC2s,ILC3s,and lymphoid tissue inducer(LTi)cells and include type I,type II,and ...
关键词:NK cell innate lymphoid cell tissue microenvironment virus infection anti-viral immunity 
DALT:the brain’s border patrol
《Cell Research》2024年第9期603-604,共2页Jang Hyun Park Jenolyn F.Alexander Leon C.D.Smyth Jonathan Kipnis 
Mucosal-associated lymphoid tissues are the immune structures that rapidly initiate local immune responses;the dura mater is the outermost layer of the meninges covering and connecting central nervous system(CNS)with ...
关键词:LYMPHOID IMMUNE 
Single-cell landscape of alternative polyadenylation in human lymphoid hematopoiesis
《Journal of Molecular Cell Biology》2024年第7期30-45,共16页Jiaqi Qiang Shan Yu Jun Li Yu Rong Xiaoshuang Wang Yong Zhu Fang Wang 
supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-040 to F.W.);the National Key Research and Development Program of China(2021YFA1102400 to F.W.,2019YFA0111700 to X.W.);the National Natural Science Foundation of China(82022001 and 81970103 to F.W.,82070111 to Y.Z.).
Alternative polyadenylation(APA)is an essential post-transcriptional process that produces mature mRNA isoforms by regulating the usage of polyadenylation sites(PASs).APA is involved in lymphocyte activation;however,i...
关键词:alternative polyadenylation HEMATOPOIESIS lymphoid differentiation post-transcription SINGLE-CELL 
Spatial relationship of tertiary lymphoid structures and tumor-associated neutrophils in bladder cancer and prognostic potential for anti-PD-L1 immunotherapy被引量:1
《Cancer Communications》2024年第4期499-503,共5页Xuechun Wang Anna Juncker-Jensen Gang Huang Mate Levente Nagy Xuemin Lu Liang Cheng Xin Lu 
supported by National Institutes of Health grants(R01CA248033 and R01CA280097);Department of Defense Congressionally Directed Medical Research Programs grants(W81XWH2010312,W81XWH2010332 and HT94252310010).
Dear Editor,Tertiary lymphoid structures(TLSs)are organized clus-ters of immune cells found in non-lymphoid tissues of chronic inflammation,including solid tumors[1].High endothelial venules(HEVs)positive for peripher...
关键词:BLADDER LYMPHOID inflammation 
Coming of age:the formation and function of age-associated B cells
《Cellular & Molecular Immunology》2024年第4期311-312,共2页Ke Rui Nan Che Kongyang Ma Hejian Zou Fan Xiao Liwei Lu 
supported by the National Natural Science Foundation of China(82071817,82171793,82371803);the Shenzhen Science and Technology Program(YCYJ20210324114602008);the Jiangsu Provincial Key Research and Development Program(BE2023758);the Hong Kong Research Grants Council(17113319,17103821);the RGC Theme-based Research Scheme(TRS)(T12-703/19-R)。
B cells are generated in the bone marrow during ontogeny and migrate to peripheral lymphoid organs,where they encounter antigens to elicit humoral immunity.During the past decade,many novel B-cell subsets with distinc...
关键词:ORGANS LYMPHOID MIGRATE 
Deep insight into the B-cell associated tertiary lymphoid structure and tumor immunotherapy被引量:1
《Cancer Biology & Medicine》2024年第2期125-131,共7页Jilong Yang Jin Xu Haotian Liu Wanyi Xiao Gengpu Zhang 
Bod et al.1 recently published a study in Nature that garnered attention to B cell-associated anti-tumor immunity and immunotherapy of melanoma and other tumors1.As a promising supplemental immunotherapy to mainstream...
关键词:IMMUNOTHERAPY IMMUNITY 
Pituitary macroadenoma apoplexy as a rare complication of Bruton tyrosine kinase inhibitor in chronic lymphoid leukaemia
《Chinese Neurosurgical Journal》2023年第4期320-325,共6页Aysha Gomaa Robert Skelly 
Background Pituitary apoplexy is a neurosurgical emergency and is a known yet rare complication of pituitary macroadenoma.Patients typically present with visual field defects,headache and altered sensorium.There are m...
关键词:Pituitary apoplexy Pituitary macroadenoma Chronic lymphocytic leukaemia CHEMOTHERAPY 
Group 2 innate lymphoid cells resolve neuroinflammation following cerebral ischaemia被引量:2
《Stroke & Vascular Neurology》2023年第5期424-434,共11页Pei Zheng Yuwhen Xiu Zhili Chen Meng Yuan Yan Li Ningning Wang Bohao Zhang Xin Zhao Minshu Li Qiang Liu Fu-Dong Shi Wei-Na Jin 
in part,by the National Natural Science Foundation of China(82071327,81971094,81771274).
Background Acute brain ischaemia elicits pronounced inflammation,which aggravates neural injury.However,the mechanisms governing the resolution of acute neuroinflammation remain poorly understood.In contrast to regula...
关键词:INFLAMMATION CEREBRAL LYMPHOID 
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