supported by the National Science Fund for Distinguished Young Scholars of China(Grant No.81925023);Joint Funds of the National Natural Science Foundation of China(Grant No.U23A20478);the National Science Foundation for Young Scientists of China(Grant No.82202267,82101996).
Background:Tertiary lymphoid structures(TLS)are major components in the immune microenvironment,correlating with a favorable prognosis in colorectal cancer.However,the methods used to define and characterize TLS were ...
supported by Natural Science Foundation of Shandong Province,China(Grant no.ZR2021MH353);Health Science and Technology Team Building Project of Shandong Province.
Tertiary lymphoid structures(TLSs)are defined as lymphoid aggregates formed in non-hematopoietic organs under pathological conditions.Similar to secondary lymphoid organs(SLOs),the formation of TLSs relies on the inte...
Innate lymphocytes(ILCs)rapidly respond to and protect against invading pathogens and cancer.ILCs include natural killer(NK)cells,ILC1s,ILC2s,ILC3s,and lymphoid tissue inducer(LTi)cells and include type I,type II,and ...
Mucosal-associated lymphoid tissues are the immune structures that rapidly initiate local immune responses;the dura mater is the outermost layer of the meninges covering and connecting central nervous system(CNS)with ...
supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-040 to F.W.);the National Key Research and Development Program of China(2021YFA1102400 to F.W.,2019YFA0111700 to X.W.);the National Natural Science Foundation of China(82022001 and 81970103 to F.W.,82070111 to Y.Z.).
Alternative polyadenylation(APA)is an essential post-transcriptional process that produces mature mRNA isoforms by regulating the usage of polyadenylation sites(PASs).APA is involved in lymphocyte activation;however,i...
supported by National Institutes of Health grants(R01CA248033 and R01CA280097);Department of Defense Congressionally Directed Medical Research Programs grants(W81XWH2010312,W81XWH2010332 and HT94252310010).
Dear Editor,Tertiary lymphoid structures(TLSs)are organized clus-ters of immune cells found in non-lymphoid tissues of chronic inflammation,including solid tumors[1].High endothelial venules(HEVs)positive for peripher...
supported by the National Natural Science Foundation of China(82071817,82171793,82371803);the Shenzhen Science and Technology Program(YCYJ20210324114602008);the Jiangsu Provincial Key Research and Development Program(BE2023758);the Hong Kong Research Grants Council(17113319,17103821);the RGC Theme-based Research Scheme(TRS)(T12-703/19-R)。
B cells are generated in the bone marrow during ontogeny and migrate to peripheral lymphoid organs,where they encounter antigens to elicit humoral immunity.During the past decade,many novel B-cell subsets with distinc...
Bod et al.1 recently published a study in Nature that garnered attention to B cell-associated anti-tumor immunity and immunotherapy of melanoma and other tumors1.As a promising supplemental immunotherapy to mainstream...
Background Pituitary apoplexy is a neurosurgical emergency and is a known yet rare complication of pituitary macroadenoma.Patients typically present with visual field defects,headache and altered sensorium.There are m...