Spatial relationship of tertiary lymphoid structures and tumor-associated neutrophils in bladder cancer and prognostic potential for anti-PD-L1 immunotherapy  

作　　者：Xuechun Wang Anna Juncker-Jensen Gang Huang Mate Levente Nagy Xuemin Lu Liang Cheng Xin Lu 

机构地区：[1]Department of Biological Sciences,Boler-Parseghian Center for Rare and Neglected Diseases,Harper Cancer Research Institute,University of Notre Dame,Notre Dame,IN,USA [2]NeoGenomics Laboratories,Inc.,Aliso Viejo,CA,USA [3]Department of Pathology and Laboratory Medicine,Brown University Warren Alpert Medical School,Lifespan Academic Medical Center,Legorreta Cancer Center at Brown University,Providence,RI,USA [4]Tumor Microenvironment and Metastasis Program,Indiana University Melvin and Bren Simon Comprehensive Cancer Center,Indianapolis,IN,USA

出　　处：《Cancer Communications》2024年第4期499-503,共5页癌症通讯（英文）

基　　金：supported by National Institutes of Health grants(R01CA248033 and R01CA280097);Department of Defense Congressionally Directed Medical Research Programs grants(W81XWH2010312,W81XWH2010332 and HT94252310010).

摘　　要：Dear Editor,Tertiary lymphoid structures(TLSs)are organized clus-ters of immune cells found in non-lymphoid tissues of chronic inflammation,including solid tumors[1].High endothelial venules(HEVs)positive for peripheral node addressin(PNAd)are present in TLSs and may pro-vide highway entry for lymphocytes.Tumor-residing TLSs may be formed by the concerted actions of cytokines and chemokines,a finding supported by the relation between a 12-chemokine signature and TLSs[2].

关 键 词：BLADDER LYMPHOID inflammation 

分 类 号：R737.14[医药卫生—肿瘤]