SINGLE-CELL

作品数：781被引量：1766H指数：20
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相关领域：医药卫生生物学更多>>
相关作者：孙莉莉徐飞齐隽陈晓巢国俊更多>>
相关机构：北京大学福建医科大学广州大学华中科技大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划北京市自然科学基金更多>>
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Utilizing Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)in hypothesis-driven queries
《Neural Regeneration Research》2026年第2期677-678,共2页Diana Acosta Cankun Wang Qin Ma Hongjun Fu 
Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other...
关键词：sex specific alzheimer s disease ad deciphering molecular mechanisms spatial transcriptomics ssread spatial transcriptomics st Alzheimers disease single cell RNA seq 
Blood-brain barrier disruption and neuroinflammation in the hippocampus of a cardiac arrest porcine model:Single-cell RNA sequencing analysis
《Neural Regeneration Research》2026年第2期742-755,共14页Tangxing Jiang Yaning Li Hehui Liu Yijun Sun Huidan Zhang Qirui Zhang Shuyao Tang Xu Niu Han Du Yinxia Yu Hongwei Yue Yunyun Guo Yuguo Chen Feng Xu 
supported by the National Science Foundation of China,Nos.82325031(to FX),82030059(to YC),82102290(to YG),U23A20485(to YC);Noncommunicable Chronic Diseases-National Science and Technology Major Project,No.2023ZD0505504(to FX),2023ZD0505500(to YC);the Key R&D Program of Shandong Province,No.2022ZLGX03(to YC).
Global brain ischemia and neurological deficit are consequences of cardiac arrest that lead to high mortality.Despite advancements in resuscitation science,our limited understanding of the cellular and molecular mecha...
关键词：Blood-brain barrier disruption cardiac arrest HIPPOCAMPUS microglia NEUROINFLAMMATION neuroprotection NEUTROPHIL oligodendrocyte dysfunction S100A8 single-cell RNA sequencing 
A single-cell landscape of the regenerating spinal cord of zebrafish
《Neural Regeneration Research》2026年第2期780-789,共10页Lei Yao Xinyi Cai Saishuai Yang Yixing Song Lingyan Xing Guicai Li Zhiming Cui Jiajia Chen 
supported by the Jiangsu Province Traditional Chinese Medicine Technology Development Plan Project,Nos.MS2023113(to JC),MS2022090;Young and Middle-aged Academic Leaders of Jiangsu Qing-Lan Project(to GL).
Unlike mammals,zebrafish possess a remarkable ability to regenerate their spinal cord after injury,making them an ideal vertebrate model for studying regeneration.While previous research has identified key cell types ...
关键词：dividing oligodendrocyte macrophage MICROGLIA neuron proliferating oligodendrocyte radial glia single cell sequencing spinal cord regeneration transcriptome ZEBRAFISH 
Changes in border-associated macrophages after stroke: Single-cell sequencing analysis
《Neural Regeneration Research》2026年第1期346-356,共11页Ning Yu Yang Zhao Peng Wang Fuqiang Zhang Cuili Wen Shilei Wang 
supported by Qingdao Key Medical and Health Discipline Project;The Intramural Research Program of the Affiliated Hospital of Qingdao University,No. 4910;Qingdao West Coast New Area Science and Technology Project,No. 2020-55 (all to SW)。
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro...
关键词：border-associated macrophages CLODRONATE hypoxia ISCHEMIA-REPERFUSION ischemic stroke liposomes neuroinflammation single-cell sequencing analysis STAT3 tumor necrosis factor 
Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration
《Neural Regeneration Research》2025年第12期3635-3648,共14页Hui Xu Lining Cao Yuxi Chen Cuiping Zhou Jie Xu Zhuolin Zhang Xiangyu Li Lihua Liu Jianfeng Lu 
supported by the National Natural Science Foundation of China,Nos.81970820(to HX),31771644(to JL),31930068(to JL),82371176(to JL),81801331(to LC);National Key Research and Development Project of China.Nos.2017YFA0104100(to JL),2017YFA0701304(to HX);Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)Talent Introduction Plan,No.KYPT202204(to LC);the Fundamental Research Funds for the Central Universities,No.22120230292(to JL)。
Inflammation plays a crucial role in the regeneration of fish and avian retinas.However,how inflammation regulates Müller glia(MG)reprogramming remains unclear.Here,we used single-cell RNA sequencing to investigate t...
关键词：immune cells inflammation Jak1-Stat3 signaling microglia Müller glia REGENERATION reprogramming RETINA single-cell RNAseq ZEBRAFISH 
Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke
《Neural Regeneration Research》2025年第7期2015-2028,共14页Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li 
supported by the National Natural Science Foundation of China,Nos.82071307(to HL),82271362(to HL),82171294(to JW),82371303(to JW),and 82301460(to PX);the Natural Science Foundation of Jiangsu Province,No.BK20211552(to HL);Suzhou Medical Technology Innovation Project-Clinical Frontier,No.SKY2022002(to ZY);the Science and Education Foundation for Health of Suzhou for Youth,No.KJXW2023001(to XL)。
Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination.Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe n...
关键词：BIOINFORMATICS bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing 
Single-cell pan-omics, environmental neurology, and artificial intelligence:the time for holistic brain health research
《Neural Regeneration Research》2025年第6期1703-1704,共2页Paolo Abondio Francesco Bruno 
The brain,with its trillions of neural connections,different cellular types,and molecular complexities,presents a formidable challenge for researchers aiming to comprehend the multifaceted nature of neural health.As t...
关键词：function artificial LANDSCAPE 
Single-cell and spatial omics:exploring hypothalamic heterogeneity
《Neural Regeneration Research》2025年第6期1525-1540,共16页Muhammad Junaid Eun Jeong Lee Su Bin Lim 
supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI);the Ministry of Health&Welfare,Republic of Korea (HR22C1734);the National Research Foundation (NRF) of Korea (2020R1A6A1A03043539,2020M3A9D8037604,2022R1C1C1004756)(to SBL);the NRF of Korea (2022R1C1C1005741 and RS-2023-00217595);the new faculty research fund of Ajou University School of Medicine (to EJL)。
Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technolo...
关键词：cellular diversity HYPOTHALAMUS multi-omics single-cell transcriptomics spatial transcriptomics 
Phosphorylation-related genes in lupus nephritis:Single-cell and machine learning insights
《Genes & Diseases》2025年第3期31-34,共4页Lisha Mou Zhihao Chen Xinran Tian Yupeng Lai Zuhui Pu Meiying Wang 
supported by the Science and Technology Program for Basic Research in Shenzhen,Guangdong,China(No.JCYJ20200109140412476,JCYJ20190809095811254,GCZX2015043017281705);the Clinical Research Project in Shenzhen,Guangdong,China(No.20213357002,20213357028);the Team-based Medical Science Research Program in Shenzhen,Guangdong,China(No.2024YZZ06);Shenzhen High-level Hospital Construction Fund in Shenzhen,Guangdong,China(No.2024).
This study investigates key genes contributing to lupus nephritis(LN).While extensive research has elucidated various aspects of LN pathogenesis,the specific involvement of phosphorylation-related genes(PRGs)in this c...
关键词：nonnegative matrix factorization nmf algorithmwe machine learning renal tissues lupus nephritis critical gene patterns single cell RNA sequencing lupus nephritis ln phosphorylation related genes 
SPP1þmacrophages in colorectal cancer:Markers of malignancy and promising therapeutic targets
《Genes & Diseases》2025年第3期428-446,共19页Zhenyu Xie Gaozan Zheng Liaoran Niu Kunli Du Ruikai Li Hanjun Dan Lili Duan Hongze Wu Guangming Ren Xinyu Dou Songchen Dai Fan Feng Jian Zhang Jianyong Zheng 
supported by the National Natural Science Foundation of China(No.82072655);the Scientific and technological innovation team of Shaanxi Innovation Capability Support Plan(China)(No.2023-CX-TD-67);the Key R&D Plan of Shaanxi Province,China(No.2022SF-603).
SPP1^(+) macrophages have been identified as key players in the colorectal cancer(CRC) tumor microenvironment, but their function remains unclear. This study integrated single-cell and spatial transcriptomics with bul...
关键词：Colorectal cancer Immunotherapy Single-cell RNA sequencing Spatial transcriptomics SPP1þmacrophages 
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