CLODRONATE

作品数:15被引量:49H指数:4
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相关领域:医药卫生更多>>
相关作者:高建川盛志勇刘强尹会男柴家科更多>>
相关机构:东南大学解放军总医院第一附属医院江苏大学附属医院江苏大学更多>>
相关期刊:《Liver Research》《中华肝胆外科杂志》《Journal of Innovative Optical Health Sciences》《解放军医学杂志》更多>>
相关基金:国家自然科学基金教育部留学回国人员科研启动基金江苏省自然科学基金国家重点基础研究发展计划更多>>
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Changes in border-associated macrophages after stroke: Single-cell sequencing analysis
《Neural Regeneration Research》2026年第1期346-356,共11页Ning Yu Yang Zhao Peng Wang Fuqiang Zhang Cuili Wen Shilei Wang 
supported by Qingdao Key Medical and Health Discipline Project;The Intramural Research Program of the Affiliated Hospital of Qingdao University,No. 4910;Qingdao West Coast New Area Science and Technology Project,No. 2020-55 (all to SW)。
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro...
关键词:border-associated macrophages CLODRONATE hypoxia ISCHEMIA-REPERFUSION ischemic stroke liposomes neuroinflammation single-cell sequencing analysis STAT3 tumor necrosis factor 
Don’t know what you got till it’s gone:microglial depletion and neurodegeneration被引量:1
《Neural Regeneration Research》2021年第10期1921-1927,共7页David Graykowski Eiron Cudaback 
This work was supported by DePaul University grant URC450622(to EC).
In the central nervous system,immunologic surveillance and response are carried out,in large part,by microglia.These resident macrophages derive from myeloid precursors in the embryonic yolk sac,migrating to the brain...
关键词:Alzheimer’s disease clodronate liposomes CSF1R depletion microglia NEURODEGENERATION neuroregeneration REPOPULATION 
Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect被引量:2
《Liver Research》2020年第3期145-152,共8页Melissa M.Clemens Joel H.Vazquez Stefanie Kennon-McGill Sandra S.McCullough Laura P.James Mitchell R.McGill 
This work was supported by the American Association for the Study of Liver Diseases Foundation,Alexandria,VA,USA(2018 Pinnacle Research Award);by the United States National Institutes of Health(grant numbers T32 GM106999,UL1 TR003107,R42 DK079387 and KL2 TR003108).
Background and aim:Acetaminophen(APAP)overdose is a major cause of acute liver injury,but the role of macrophages in the propagation of the hepatotoxicity is controversial.Early research revealed that macrophage inhib...
关键词:Acetaminophen(APAP) Acute liver failure(ALF) Damage-associated molecular patterns(DAMPs) Drug-induced liver injury Liposomal clodronate(LC) Kupffer cells Nuclear factor erythroid 2-related factor(Nrf2) Sterile inflammation Stress response 
Monocyte-derived fibrocytes elimination had little contribution on liver fibrosis
《Hepatobiliary & Pancreatic Diseases International》2019年第4期348-353,共6页Yoshinori Ozono Kotaro Shide Fumiyo Toyoshima Yuuka Takaishi Mai Tsuchimochi Ayako Kamiunten Takuro Kameda Kenichi Nakamura Tadashi Miike Kazunori Kusumotoa Hisayoshi Iwakiri Satoru Hasuikea Kenji Nagata Akira Sawaguchi Kazuya Shimoda 
supported by grants-in-aid for Scientific Research C(16K09852)and B(17H04210)from the Japan Society for the Promotion of Science;research grants from the Shinnihon Foundation of Advanced Medical Treatment Research,SENSHIN Medical Research Foundation;a grant-in-aid for Clinical Research from Miyazaki University Hospital
Background:Monocyte-derived fibrocytes play an important role in the progression of fibrosis in the skin,lungs,heart and kidney.However,the contribution of fibrocytes to liver fibrosis is unclear.The aim of this study...
关键词:FIBROCYTES Liver fibrosis Carbon TETRACHLORIDE CLODRONATE Collagen-I 
Macrophage depletion and Schwann cell transplantation reduce cyst size after rat contusive spinal cord injury被引量:4
《Neural Regeneration Research》2018年第4期684-691,共8页Yee-Shuan Lee Lucy H.Funk Jae K.Lee Mary Bartlett Bunge 
NINDS R01NS09923(MBB);R01NS081040(JKL);The Miami Project to Cure Paralysis;the Buoniconti Fund
Schwann cell transplantation is a promising therapy for the treatment of spinal cord injury(SCI) and is currently in clinical trials.In our continuing efforts to improve Schwann cell transplantation strategies,we so...
关键词:Schwann cell Iiposome clodrosome CLODRONATE axon regeneration Schwann cell survival NEUROPROTECTION glial scar CYST cell transplantation 
Are gastric mucosal macrophages responsible for gastric injury in acute pancreatitis?被引量:4
《World Journal of Gastroenterology》2015年第9期2651-2657,共7页Sheng-Chun Dang Hao Wang Jian-Xin Zhang Lei Cui De-Li Jiang Rong-Fang Chen Jian-Guo Qu Xiang-Qian Shen Min Chen Min Gu 
Supported by Jiangsu Planned Projects for Postdoctoral Research Funds,No.1302096B;Natural Science Foundation of Jiangsu Province,No.BK2011484 and No.2012704;National Natural Science Foundation of China,No.81070287
AIM:To investigate the protective effect of clodronatecontaining liposomes against severe acute pancreatitis(SAP)-triggered acute gastric mucosal injury(AGMI) in rats.METHODS:Clodronate- and phosphate-buffered saline(...
关键词:PANCREATITIS CLODRONATE DISODIUM MACROPHAGE Gastri 
Clodronate-superparamagnetic iron oxide-containing liposomes attenuate renal injury in rats with severe acute pancreatitis被引量:2
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2014年第6期556-565,共10页Sheng-chun DANG Yan-hua ZENG Ping-jiang WANG Bao-ding CHEN Rong-fang CHEN Arun KUMAR SINGH Pankaj KUMAR Shu FENG Lei CUI Hao WANG Jian-xin ZHANG 
Project supported by the National Natural Science Foundation of China(No.81070287);the Natural Science Foundation of Jiangsu Province(Nos.BK2011484 and 2012704),China
Background and objective: It has been shown that macrophages play an important role in the development of severe acute pancreatitis (SAP), and eventually lead to multiple organ failure (MOF). Clodronate-liposome ...
关键词:PANCREATITIS Clodronate disodium MACROPHAGE Kidney injury 
STUDYING THE ROLE OF MACROPHAGES IN CIRCULATING PROSTATE CANCER CELLS BY IN VIVO FLOW CYTOMETRY被引量:2
《Journal of Innovative Optical Health Sciences》2012年第4期39-47,共9页JIN GUO ZHICHAO FAN ZHENGQIN GU XUNBIN WEI 
supported by the National Basic Research Program of China(973Program,2011CB910404 and 2012CB966800);China National Natural Science Foundation(30901432 and 30972949);the Chinese Ministry of Education(109056);Program for New Century Excellent Talents in University Award(NCET-08-0131);Shanghai Science and Tech-nology Committee(11DZ2211000).
Metastasis is a very complicated multi-step process and accounts for the low survival rate of the cancerous patients.To metastasize,t he malignant cells must detach from the primary tumor and migrate to secondary site...
关键词:Prostate cancer MACROPHAGES liposome-encapsulated clodronate in vrivo flow cytometer circulating tumor cells 
Protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with severe acute pancreatitis被引量:11
《Hepatobiliary & Pancreatic Diseases International》2011年第5期544-551,共8页Jian-Xin Zhang, Sheng-Chun Dang, Kai Yin and De-Li Jiang Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China  School of Chemistry and Chemical Engineering of Jiangsu University, Zhenjiang 212013, China 
supported by grants from the National Natural Science Foundation of China (81070287 and 30772117);the Graduate Research and Innovation Program of Jiangsu University (CX10B_010X)
BACKGROUND: Severe acute pancreatitis (SAP) can result in intestinal mucosal injury. This study aimed to demonstrate the protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with S...
关键词:PANCREATITIS clodronate disodium MACROPHAGE intestinal mucosal injury 
Clodronate-containing liposomes attenuate lung injury in rats with severe acute pancreatitis被引量:4
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2010年第11期828-835,共8页Sheng-chun DANG De-li JIANG Min CHEN Di LI Jian-xin ZHANG 
Project supported by the National Natural Science Foundation of China(No.30772117);the Science Foundation of Jiangsu Province of China(No.BK2007096)
Objectives: Severe acute pancreatitis (SAP) can lead to acute lung injury (ALl). The purpose of this paper is to investigate the protective effect of clodronate-containing liposomes on ALl in rats with SAP. Meth...
关键词:PANCREATITIS Clodronate disodium MACROPHAGE Lung injury 
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