Liver transplantation is the only curative therapy for end stage liver disease,but is limited by the organ shortage,and is associated with the adverse consequences of immunosuppression.Repopulation of decellularised w...
The Basic Science Research Program Through The National Research Foundation of Korea(NRF)Grant Funded By The Korean Government To Lee S.J.,No.2021R1F1A1052084.
BACKGROUND Bone marrow(BM)suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to irradiation.Despite concerted efforts,there is no definitive treatment ...
This work was supported by DePaul University grant URC450622(to EC).
In the central nervous system,immunologic surveillance and response are carried out,in large part,by microglia.These resident macrophages derive from myeloid precursors in the embryonic yolk sac,migrating to the brain...
supported by the National Institutes of Health,National Institute on Alcoholism and Alcohol Abuse(P60AA011605-Fulton Crews,U01AA020023-Fulton Crews,U24AA020024-Fulton Crews,U54AA019767-Fulton Crews,T32AA007573-Fulton Crews;K08AA024829-Leon G Coleman,Jr;K08AA024829S1-Leon G Coleman,Jr,and the Bowles Center for Alcohol Studies).
Microglia have multiple functions and phenotypes that can prevent or worsen neuropathology.Microglial depletion and repopulation methods provide a promising technique for understanding microglial biology.Their utility...
Cell competition is now a well-established quality control strategy to optimize cell and tissue fitness in multicellular organisms.While pursuing this goal,it is also effective in selecting against altered/defective c...
The authors apologize to the authors whose work could not be included in this review due to limited space.We acknowledge Dr.Ralph Weichselbaumat University of Chicago and Dr.Yang-Xin Fu at University of Texas Southwestern for their invaluable discussions on radiation-associated tumor immunoregulation,and Ms.Angela Evans at University of California Davis for proofreading the manuscript。
Cancer radiotherapy(RT)demonstrates the benefit of local control with fewer side-effects compared to chemotherapy.To further improve the overall efficacy of RT and RT-combined therapies,studies revealing the mechanism...
the National Natural Science Foundations of China(No.81730052);the Interdisciplinary Cooperation Project of Beijing Nova Program(Z1811100006218127);the National Major Scientific and Technological Special Project for"Significant New Drugs Development"(2018ZX09711003-001-002);the National Key Research and Development Program of China(No.2016YFC1101305);the Science and Technology Planning Project of Guangdong China(2015A050502023);the Guangdong Province Science and Technology Program(2018KJYZ021);Science and Technology Program of Guangzhou,China(STPG;2016201604030054).
We report the generation of human ESC-derived,expandable hepatic organoids(hEHOs)using our newly established method with wholly defined(serum-free,feeder free)media.The hEHOs stably maintain phenotypic features of bip...
It has been realized that the 4Rs(repair,repopulation,redistribution,and reoxygenation)would affect the result of cell irradiation,and thus radiation treatment.The 4Rs each occurs at different dose rates,usually very ...
AIM To develop appropriate humanized three-dimensional ex-vivo model system for drug testing. METHODS Bioengineered humanized livers were developed in this study using human hepatic stem cells repopulation within the ...
supported by the National Natural Science Foundation of China(Grant Nos.30801115,31271474 and 81471948);National Key Basic Research and Development Program of China(Grant No.2011CB966200)
Prof.He Zhiying and colleagues from the Second Military Medical University published their research findings entitled"Non-viral FoxMl gene delivery to hepatocytes enhances liver repopulation"in Cell Death and Disease(...