ORTHOTOPIC

作品数：126被引量：332H指数：8
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Engineering high-performance chemiluminescent probes via enzymatic pocket targeting:high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma
《Science China Chemistry》2025年第3期1175-1184,共10页Shuai Huang Shuaige Bai Ting Luo Bin Feng Min Liu Fan Zheng Shuang Huang Yanpeng Fang Dan Ding Wenbin Zeng 
supported by the National Natural Science Foundation of China (82272067,22107123,and M-0696);the Natural Science Foundation of Hunan Province (2022JJ80052)。
Hepatocellular carcinoma(HCC)is a highly aggressive liver malignancy and the main form of liver cancer.Early diagnosis and treatment of HCC can effectively reduce mortality.Carboxylesterase(CE)-specific detection and ...
关键词：chemiluminescent probes CARBOXYLESTERASE high-throughput inhibitor screening long-lived chemiluminescent image image-guided surgery 
A surgical orthotopic xenograft approach with immune response for colorectal cancer research
《Animal Models and Experimental Medicine》2025年第3期558-567,共10页Xiaoying Hou Xiaoxuan Li Qian Fang Yufei Deng Haiping Wang Binlian Sun Chengliang Zhang Hongzhi Du Yuchen Liu 
Research Fund of Jianghan University,Grant/Award Number:2021jczx-002;Natural Science Foundation of Hubei Province,Grant/Award Number:2024AFB941 and 2024AFD241;Wuhan Science and Technology Project,Grant/Award Number:2023010201020448;National Natural Science Foundation of China,Grant/Award Number:82204416。
The high morbidity and mortality of colorectal cancer(CRC)is a major challenge in clinical practice.Although a series of alternative research models of CRC have been developed,appropriate orthotopic animal models that...
关键词：animal model colorectal cancer orthotopic tumor model tumor immunology 
Localized production of LECT2 by orthotopic histiocytes during inflammation
《Journal of Genetics and Genomics》2024年第12期1517-1520,共4页Zhenhan Huang Xiaojun Yang Xun Qin Kemin Chen Wei Liu Jin Xu Jianchao Li Wenqing Zhang Zhibin Huang 
funded by the National Natural Science Foundation of China(32170830);the Natural Science Foundation of Guangdong Province(2021A1515010422)。
Leukocyte cell-derived chemotaxin 2(LECT2),initially identified as a multifunctional protein secreted by hepatocytes and involved in diverse hepatic pathophysiological processes(Yamagoe et al.,1998;Xie et al.,2022),is...
关键词：INFLAMMATION LECT2 
Weitiao No.3(微调3号方)enhances the efficacy of anti-programmed cell death protein-1 immunotherapy by modulating the intestinal microbiota in an orthotopic model of gastric cancer mice
《Journal of Traditional Chinese Medicine》2024年第5期906-915,共10页HUANG Xiaona LI Yuzhen ZHU Chenyang ZHU Hengzhou JIANG Chenyu ZHU Xiaodan ZHANG Chencen JIN Chunhui 
the National Natural Science Foundation of China:to Explore the Role and Mechanism of Weitiao No.3 in Promoting Immunotherapy of Gastric Cancer by Activating Peroxisome Proliferator-activated Receptor-γ/AMP-activated Protein Kinase Signaling Pathway through Short Chain Fatty Acid based on Intestinal Flora(No.82274269);the Nature Foundation of Nanjing University of Chinese Medicine:to Investigate the Effect and Mechanism of Weitiao No.3 on Immunotherapy of Gastric Cancer based on Peroxisome Proliferator-activated Receptor-γ/AMP-activated Protein Kinase Signaling Pathway(No.XZR2020079);the Wuxi Administration of Traditional Chinese Medicine Scientific Research Project:Clinical and Basic Study on the Effect of Weitiao No.3 Mixture on Immunotherapy of Gastric Cancer by Regulating Intestinal Microecology(No.ZYKJ201906)。
OBJECTIVE:To explore the effects of Weitiao No.3(微调3号方,WD-3)on anti-programmed cell death protein-1(PD-1)immunotherapy in gastric cancer(GC).METHODS:The intestinal microbiota was analyzed by 16S rDNA sequencing of...
关键词：stomach neoplasms IMMUNOTHERAPY programmed cell death 1 receptor gastrointestinal microbiome Weitiao No.3 
Targeting stroma and tumor,silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma被引量：3
《Acta Pharmaceutica Sinica B》2024年第1期292-303,共12页Tahereh Setayesh Ying Hu Farzam Vaziri Xin Chen Jinping Lai Dongguang Wei Yu-Jui Yvonne Wan 
The authors thank the Genomics Shared Resource(GSR)core facility at the University of California,Davis Health,Dr.Clifford G Tepper,Stephanie Liu,Ryan Davis,for helping in performing spatial RNA sequencing,and William Amato for his assistance in the quantification of immunohistochemistry slides.This manuscript is supported by grants funded by the USA National Institutes of Health(NIH)T32 CA108459e15,R01CA222490,R50CA243787.BioRender was used to draw mice figures in schematic experimental design.
This study examines inhibiting galectin 1(Gal1)as a treatment option for hepatocellular carcinoma(HCC).Gal1 has immunosuppressive and cancer-promoting roles.Our data showed that Gal1 was highly expressed in human and ...
关键词：Liver Hepatocellular carcinoma Carbohydrate-binding lectin Galectin 1 Extracellular matrix Translation Spatial transcriptomics Tumor-margin 
Establishment of image-guided radiotherapy of orthotopic hepatocellular carcinoma mouse model被引量：1
《Animal Models and Experimental Medicine》2023年第5期419-426,共8页Kaixiao Zhou Yabo Jiang Shuang Feng Wei Mo Jing Nie Jianping Cao Yang Jiao 
Key R&D Program of China,Grant/Award Number:2022YFC2503700 and 2022YFC2503703;National Natural Science Foundation of China,Grant/Award Number:81773226,82103483 and U1967220;Shanghai Sailing Program,Grant/Award Number:20YF1459700。
Background:Hepatocellular carcinoma(HCC)is the most common type of liver cancer.Recently,developments in radiotherapy technology have led to radiotherapy becoming one of the main therapeutics of HCC.Therefore,a suitab...
关键词：hepatocellular carcinoma orthotopic model RADIOTHERAPY 
A cadaveric breast cancer tissue phantom for phase-contrast X-ray imaging applications
《Animal Models and Experimental Medicine》2023年第5期427-432,共6页Cody C.Rounds Chengyue Li Wei Zhou Kenneth M.Tichauer Jovan G.Brankov 
National Institutes of Health,Grant/Award Number:EB023969 and HL154687。
Background:As mammography X-ray imaging technologies advance and provide elevated contrast in soft tissues,a need has developed for reliable imaging phantoms for use in system design and component calibration.In advan...
关键词：breast tumors digital mammography imaging phantoms orthotopic animal models phasecontrast X-ray imaging 
Glioma cell membrane camouflaged cinobufotalin delivery system for combinatorial orthotopic glioblastoma therapy被引量：1
《Nano Research》2023年第8期11164-11175,共12页Zibin Song Liqian Zhao Weiyi Fang Siyun Guo Anqi Xu Zhengming Zhan Yonghua Cai ShuaiShuai Xue Peng Chai Qiuhua Jiang Peng Zhao Ye Song 
supported by the National Natural Science Foundation of China(Nos.81872064 and 82272879);the Natural Science Fund of Guangdong Province,China(No.2021A1515012465);Technology Program of Guangzhou(No.202206010068);Major Discipline and Academic Leader Training Program of Jiangxi Province(No.20225BCJ23001).
Glioblastoma(GBM)belongs to the deadliest primary malignancies with high mortality rate and poor prognosis.Over the past decades,less progress has been made to treat GBM,owing largely to the lack of effective chemothe...
关键词：GLIOBLASTOMA cinobufotalin biomimetics photothermal therapy blood-brain barrier 
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant
《Frontiers of Medicine》2023年第3期527-533,共7页Kevin M.Veen Grigorios Papageorgiou Casper F.Zijderhand Mostafa M.Mokhles Jasper J.Brugts Olivier C.Manintveld Alina A.Constantinescu Jos A.Bekkers Johanna J.Makkenberg Ad J.J.CBogers Kadir Caliskan 
In this study,we aim to elucidate the clinical impact and long-term course of tricuspid regurgitation(TR),taking into account its dynamic nature,after biatrial orthotopic heart transplant(OHT).All consecutive adult pa...
关键词：orthotopic heart transplant tricuspid regurgitation clinical impact biatrial heart transplantation 
Orthotopic implantable liver decellularized scaffold for acute liver failure
《Engineered Regeneration》2023年第1期12-19,共8页Jinglin Wang Xueqian Qin Senzhe Xia Shujun Liu Haozhen Ren 
supported by the National Natural Science Foundation of China (82270646,82100664);the Fundamental Research Funds for the Central Universities (0214-14380510);the Nanjing health science and technology development project for Distinguished Young Scholars (JQX19002);the Natural Science Foundation of Jiangsu Province (BK20190114);Jiangsu Province Postdoctoral Research Funding Program (2021K116B);Key Project supported by Medical Science and technology development Foundation,Nanjing Department of Health (YKK19070);Project of Modern Hospital Management and Development Institute,Nanjing University and Aid project of Nanjing Drum Tower Hospital Health,Education&Research Foundation (NDYG2020047);fundings for Clinical Trials from the Affiliated Drum Tower Hospital,Medical School of Nanjing University (2021-LCYJ-PY-46,2022-LCYJ-PY-35);the Chen Xiao-ping Foundation for the Development of Science and Technology of Hubei Province,China (CXPJJH121001-2021073,CXPJJH122002-019).
Decellularized scaffolds have an irreplaceable role in the development of tissue engineering.Challenges in this field are concentrated on shaping macro-scale constructs and maintaining blood flow.Here,we establish a w...
关键词：Decellularized scaffolds Orthotopic implant Acute liver failure Tissue engineering Extracellular matrix 
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