Localized production of LECT2 by orthotopic histiocytes during inflammation  

作　　者：Zhenhan Huang Xiaojun Yang Xun Qin Kemin Chen Wei Liu Jin Xu Jianchao Li Wenqing Zhang Zhibin Huang 

机构地区：[1]The Innovation Centre of Ministry of Education for Development and Diseases,School of Medicine,South China University of Technology,Guangzhou,Guangdong 510006,China [2]Greater Bay Biomedical Innocenter,Shenzhen Bay Laboratory,Shenzhen,Guangdong 518055,China

出　　处：《Journal of Genetics and Genomics》2024年第12期1517-1520,共4页遗传学报（英文版）

基　　金：funded by the National Natural Science Foundation of China(32170830);the Natural Science Foundation of Guangdong Province(2021A1515010422)。

摘　　要：Leukocyte cell-derived chemotaxin 2(LECT2),initially identified as a multifunctional protein secreted by hepatocytes and involved in diverse hepatic pathophysiological processes(Yamagoe et al.,1998;Xie et al.,2022),is also a prominent amyloid fibril protein in both renal and hepatic amyloidosis(Mann et al.,2022).Recently,LECT2 has been implicated in immune processes across various pathologies,including hepatocellular carcinoma(HCC),nonalcoholic fatty liver disease(NAFLD),sepsis,atherosclerosis,arthritis,and allergic diseases(Zhu et al.,2023).

关 键 词：INFLAMMATION LECT2 

分 类 号：R392[医药卫生—免疫学]