Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment  

作　　者：Mengyao Yang Xin Wang Mengke Peng Fei Wang Senlin Hou Ruirui Xing Aibing Chen 

机构地区：[1]College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang 050018,People’s Republic of China [2]State Key Laboratory of Biopharmaceutical Preparation and Delivery,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,People’s Republic of China [3]The Second Hospital of Hebei Medical University,Shijiazhuang 050000,People’s Republic of China

出　　处：《Nano-Micro Letters》2025年第7期126-159,共34页纳微快报(英文版)

基　　金：supported by the National Natural Science Foundation of China(Nos.U23A20573,U23A20140,22072154,and 22377127);Hebei Natural Science Foundation(B2024208046 and H2022423314);Huang jin tai plan project of Hebei provincial department of education(HJZD202512);S&T Program of Hebei,the Youth innovation Promotion Association of Chinese Academy of Sciences(No.2021048);the Beijing Nova Program(No.20230484352).

摘　　要：Sonodynamic therapy(SDT)as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound(US),which can safely penetrate the tissue without significant attenuation.SDT not only has the advantages including high precision,non-invasiveness,and minimal side effects,but also overcomes the limitation of low penetration of light to deep tumors.The cytotoxic reactive oxygen species can be produced by the utilization of sonosensitizers combined with US and kill tumor cells.However,the underlying mechanism of SDT has not been elucidated,and its unsatisfactory efficiency retards its further clinical application.Herein,we shed light on the main mechanisms of SDT and the types of sonosensitizers,including organic sonosensitizers and inorganic sonosensitizers.Due to the development of nanotechnology,many novel nanoplatforms are utilized in this arisen field to solve the barriers of sonosensitizers and enable continuous innovation.This review also highlights the potential advantages of nanosonosensitizers and focus on the enhanced efficiency of SDT based on nanosonosensitizers with monotherapy or synergistic therapy for deep tumors that are difficult to reach by traditional treatment,especially orthotopic cancers.

关 键 词：Sonodynamic therapy Nanosonosensitizers Tumor accumulation Surmounting the hypoxia Orthotopic tumor 

分 类 号：R730.5[医药卫生—肿瘤]