A cadaveric breast cancer tissue phantom for phase-contrast X-ray imaging applications  

作　　者：Cody C.Rounds Chengyue Li Wei Zhou Kenneth M.Tichauer Jovan G.Brankov 

机构地区：[1]Biomedical Engineering,Illinois Institute of Technology,Chicago,Illinois,USA [2]Medical Imaging Research Center,Illinois Institute of Technology,Chicago,Illinois,USA [3]Electrical and Computer Engineering,Illinois Institute of Technology,Chicago,Illinois,USA

出　　处：《Animal Models and Experimental Medicine》2023年第5期427-432,共6页动物模型与实验医学（英文）

基　　金：National Institutes of Health,Grant/Award Number:EB023969 and HL154687。

摘　　要：Background:As mammography X-ray imaging technologies advance and provide elevated contrast in soft tissues,a need has developed for reliable imaging phantoms for use in system design and component calibration.In advanced imaging modalities such as refraction-based methods,it is critical that developed phantoms capture the biological details seen in clinical precancerous and cancerous cases while minimizing artifacts that may be caused due to phantom production.This work presents the fabrication of a breast tissue imaging phantom from cadaveric breast tissue suitable for use in both transmission and refraction-enhanced imaging systems.Methods:Human cancer cell tumors were grown orthotopically in nude athymic mice and implanted into the fixed tissue while maintaining the native tumor/adipose tissue interface.Results:The resulting human–murine tissue hybrid phantom was mounted on a clear acrylic housing for absorption and refraction X-ray imaging.Digital breast tomosynthesis was also performed.Conclusion:Both attenuation-based imaging and refraction-based imaging of the phantom are presented to confirm the suitability of this phantom's use in both imaging modalities.

关 键 词：breast tumors digital mammography imaging phantoms orthotopic animal models phasecontrast X-ray imaging 

分 类 号：R-332[医药卫生]