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2D4,a humanized monoclonal antibody targeting CD132,is a promising treatment for systemic lupus erythematosus
《Signal Transduction and Targeted Therapy》2024年第12期5693-5707,共15页Huiqi Yin Liming Li Xiwei Feng Zijun Wang Meiling Zheng Junpeng Zhao Xinyu Fan Wei Wu Lingyu Gao Yijing Zhan Ming Zhao Qianjin Lu 
supported by following fundings:the National Key R&D Program of China(No.2022YFC3601800);the CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-059);non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-RC320-001,No.2020-RC320-003);the Special Program of National Natural Science Foundation of China(NO.32141004);the Special Research Fund for Central Universities,Peking Union Medical College(No.3332023075);Natural Science Foundation of Jiangsu Province(No.BK20230130);National Natural Science Foundation of China(No.82302982).
Current therapies for systemic lupus erythematosus that target a particular factor or cell type exhibit limited effectiveness.To address this limitation,our focus was on CD132,a subunit common to six inflammatory fact...
关键词：CD13 LUPUS ERYTHEMATOSUS 
Skin care efficacy study of recombinant humanized collagen based on in vitro level
《日用化学工业（中英文）》2024年第9期1030-1038,共9页Jian Wang Yuhui Fan Danfeng Li Ningwen Cheng Ling Li Yufeng Yu 
Studying the skin care efficacy of recombinant humanized collagen based on in vitro level.The stability of the recombinant humanized collagen was first analyzed by treating at different temperatures,then its skincare ...
关键词：recombinant humanized collagen stability human fibroblast cell in vitro keratinocytes skin care efficacy 
Research on the Application Effect of Humanized Nursing Management in Pediatric Rehabilitation Wards
《Journal of Clinical and Nursing Research》2024年第7期54-59,共6页Yan Sun 
Objective:To explore the application effect of humanized nursing management in pediatric rehabilitation wards.Methods:82 pediatric patients admitted to our hospital between January 2023 and January 2024 were randomly ...
关键词：Humanized nursing CHILDREN Rehabilitation ward Application effect 
Assessment of HER2 status in extramammary Paget disease and its implication for disitamab vedotin,a novel humanized anti-HER2 antibody-drug conjugate therapy
《Frontiers of Medicine》2024年第3期565-569,共5页Jia Jia Lili Mao Jing Lin Wenyu Li Pei Yuan Lei Guo Jie Dai Caili Li Xue Bai Zhongwu Li Yu Chen Jun Guo Jianming Ying Lu Si 
supported by Beijing Medical Award Foundation(No.YXJL-2020-0889-0106);Beijing Municipal Administration of Hospitals’Ascent Plan(No.DFL20220901);Beijing Xisike Clinical Oncology Research Foundation(Nos.Y-Roche2019/2-0076 and Y-SY201901-0270).
Dear Editor,Extramammary Paget disease(EMPD)is a rare adenocarcinoma that originates in the apocrine gland-rich skin and usually affects the perineal skin(primary EMPD)or represents the intraepithelial spread of an un...
关键词：PAGET HER2 ADENOCARCINOMA 
Establishment of a humanized mouse model using steady-state peripheral blood-derived hematopoietic stem and progenitor cells facilitates screening of cancer-targeted T-cell repertoires
《Cancer Innovation》2024年第3期1-21,共21页Yulin Xu Wei Shan Qian Luo Meng Zhang Dawei Huo Yijin Chen Honghu Li Yishan Ye Xiaohong Yu Yi Luo He Huang 
National Natural Science Foundation of China,Grant/Award Numbers:82130003,81970158,82000180;Zhejiang Provincial Key R&D Projects of Department of Science and Technology,Grant/Award Number:2021C03010;Zhejiang Provincial Natural Science Foundation of China,Grant/Award Numbers:LTGY24H080003,LY21H080004。
Background:Cancer-targeted T-cell receptor T(TCR-T)cells hold promise in treating cancers such as hematological malignancies and breast cancers.However,approaches to obtain cancer-reactive TCR-T cells have been unsucc...
关键词：cancer-targeted T-cell receptor T(TCR-T)cells circulating hematopoietic stem and progenitor cells(HSPCs) humanized mouse model steady-state peripheral blood T-cell receptorβ-chain(TRB) three-dimensional culture 
Cartilage-like protein-polysaccharide hybrid hydrogel for enhancing chondrogenic differentiation of bone marrow mesenchymal stem cells
《Collagen and Leather》2024年第2期129-140,共12页Xinyue Zhang Xue Zhan Haojin Cheng Zuqin Dong Chen Hu Chenxin Liu Jie Liang Yafang Chen Yujiang Fan Xingdong Zhang 
supported by the National Key Research and Development Program of China(Grant No.2022YFC2401800);Fundamental Research Funds for the Central Universities(2022SCU12104);the National Natural Science Foundation of China(Grant No.51973136);Sichuan University postdoctoral interdisciplinary Innovation Fund.
The regeneration of articular cartilage posed a formidable challenge due to the restricted treatment efficacy of exist-ing therapies.Scaffold-based tissue engineering emerges as a promising avenue for cartilage recons...
关键词：Chondrogenic differentiation Recombinant humanized collagen Hyaluronic acid Dopamine hydrochloride Articular cartilage 
Operation room nursing based on humanized nursing mode combined with nitric oxide on rehabilitation effect after lung surgery
《World Journal of Clinical Cases》2024年第18期3368-3377,共10页Qiao-Li Wang Zhi-Bo Wang Jin-Fu Zhu 
BACKGROUND With advancements in the diagnosis and treatment of lung diseases,lung segment surgery has become increasingly common.Postoperative rehabilitation is critical for patient recovery,yet challenges such as com...
关键词：Humanized nursing Nitric oxide Lung segment surgery REHABILITATION Pulmonary function 
Establishment of a humanized ST6GAL1 mouse model for influenza research
《Animal Models and Experimental Medicine》2024年第3期337-346,共10页Lyu Chao Han Feng Gao Qian Lv Limin Lu Ziwei Lu Shuangshuang Li Xiaoyan Hu Yuechao Yang Mengjie Zhao Yingze Liu Jun Lu Xuancheng Duo Shuguang 
National Key Research and Development Program of China,Grant/Award Number:2021YFC2301403 and 2022YFF0711000。
Background:This study aimed to construct and characterize a humanized influenza mouse model expressing hST6GAL1.Methods:Humanized fragments,consisting of the endothelial cell-specific K18 promoter,human ST6GAL1-encodi...
关键词：hST6GAL1 humanized mice influenza animal model 
Application and Satisfaction Analysis of Humanized Quality Nursing Intervention in the Care of Patients with Critical Respiratory Failure
《Journal of Clinical and Nursing Research》2024年第5期200-205,共6页Li Xu 
Objective:To implement humanized quality care in critical respiratory failure nursing,observe the effect,and analyze the satisfaction.Methods:80 patients with severe respiratory failure were divided into 40 cases per ...
关键词：Critical respiratory failure Humanized quality nursing Nursing satisfaction 
A strategy for mechanically integrating robust hydrogeltissue hybrid to promote the anti-calcification and endothelialization of bioprosthetic heart valve
《Regenerative Biomaterials》2024年第2期123-136,共14页Haoshuang Wu Nuoya Chen Tiantian Zheng Li Li Mengyue Hu Yumei Qin Gaoyang Guo Li Yang Yunbing Wang 
supported by National Key Research and Development Programs(2022YFB3807303 and 2022YFB3807305),National Natural Science Foundation of China(32101107)and CAMS InnovationFundforMedical Sciences(2021-12M-5-013)。
Bioprosthetic heart valve(BHV)replacement has been the predo-minant treatment for severe heart valve diseases over decades.Most clinically available BHVs are crosslinked by glutaraldehyde(GLUT),while the high toxicity...
关键词：bioprosthetic heart valves recombinant humanized collagen typeⅢ ENDOTHELIALIZATION ANTI-CALCIFICATION ANTI-COAGULATION 
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