云南高校图书馆联盟文献共享服务平台- HEPATOCYTE

HEPATOCYTE: 作品数：324被引量：1213H指数：17; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王小众欧瑜吕正兵吴梧桐王秋娟更多>>; 相关机构：北京大学南方医科大学福建医科大学中国药科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家高技术研究发展计划更多>>

P2Y_(14)R activation facilitates liver regeneration via CREB/DNMT3b/Dact-2/β-Catenin signals in acute liver failure: 《Acta Pharmaceutica Sinica B》2025年第2期919-933,共15页Mengze Zhou Yehong Li Jialong Qian Xinli Dong Yanshuo Guo Li Yin Chunxiao Liu Kun Hao Qinghua Hu; supported by National Natural Science Foundation of China(No.82373887 to Qinghua Hu,No.82304506 to Mengze Zhou);Natural Science Foundation of Jiangsu Province(BK20211223 to Qinghua Hu,BK20231022 to Mengze Zhou,China);China Postdoctoral Science Foundation(2022M723513 to Mengze Zhou);the Fundamental Research Funds for the Central Universities(2632024TD01 to Qinghua Hu,2632023GR23 to Mengze Zhou,China).; Acute liver failure(ALF)is lack of broadly approved therapeutic strategy except liver transplantation.As a glycogen metabolic intermediate,UDP-glucose(UDP-G)has been considered to accelerate liver repairment.Neverthel...; 关键词：Acute liver failure UDP-GLUCOSE P2Y_(14)R Liver regeneration HEPATOCYTE Partial hepatectomy b-Catenin Dact-2

Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity: 《Acta Pharmaceutica Sinica B》2025年第2期963-972,共10页Yin Zhu Yuyin Wang Keito Hoshitsuki Da Yang Lauren Kokai Xiaochao Ma Wen Xie Christian A.Fernandez; supported by the University of Pittsburgh School of Pharmacy and NIH Grants R01CA216815 and R01DK140079(USA).; One of the leading therapies for acute lymphoblastic leukemia(ALL)is the chemotherapeutic agent PEGylated E.coli-derived-l-asparaginase(PEG-ASNase).Due to the high risk of dose-limiting liver injury,characterized by c...; 关键词：Liver injury ASPARAGINASE LIPOLYSIS LIPOTOXICITY Oxidative stress ATGL CYP2E1

Dietary ferulic acid supplementation enhances antioxidant capacity and alleviates hepatocyte pyroptosis in diquat challenged piglets: 《Journal of Animal Science and Biotechnology》2025年第1期377-387,共11页Junqiu Luo Xiu Wu Daiwen Chen Bing Yu Jun He; Sichuan Science and Technology Program(No.2021ZDZX0009).; Background Oxidative stress significantly impacts growth performance and liver function in piglets.Ferulic acid(FA)works as an antioxidant,however,the role and mechanism of FA in the regulation of diquat-induced oxida...; 关键词：Antioxidant capacity Ferulic acid Hepatic pyroptosis PIGLETS

Baicalin-induced hepatocyte toxicity:The critical role of multidrug resistance-associated protein 2: 《Integrative Medicine Discovery》2025年第1期1-4,共4页Naohiro Oshima Kosuke Kusamori Ryo Takasaki Noriyasu Hada Makiya Nishikawa; supported by the JSPS KAKENHI(Grant Number:JP22K06676)。; Background:Scutellaria root(root of Scutellaria baicalensis),which has potent anti-inflammatory effects,is a component of useful traditional formulaes.Albeit a low frequency,it has been reported to cause severe inters...; 关键词：BAICALIN MRP2 cytotoxicity HepG2 cells Scutellaria root

Activation of pregnane X receptor protects against cholestatic liver injury by inhibiting hepatocyte pyroptosis: 《Acta Pharmacologica Sinica》2025年第1期147-158,共12页Hang-fei Liang Xiao Yang Hui-lin Li Xuan Li Jia-ning Tian Hai-guo Su Min Huang Jian-hong Fang Hui-chang Bi; The work was supported by the National Key Research and Development Program of China(2022YFA1106700,2022YFA1104900);the National Natural Science Foundation of China(U23A20535,82025034,82274001,81973392,82204226);Guangdong Basic and Applied Basic Research Foundation(SL2022A04J01943);the Shenzhen Science and Technology Program(KQTD20190929174023858);the 111 project(B16047);the Key Laboratory Foundation of Guangdong Province(2017B030314030);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093).; Our previous study shows that activation of pregnane X receptor(PXR)exerts hepatoprotection against lithocholic acid(LCA)-induced cholestatic liver injury.In this study we investigated whether PXR activation could inh...; 关键词：cholestatic liver injury pregnane X receptor pregnenolone 16a-carbonitrile PYROPTOSIS NLRP3 APAF-1

Nonalcoholic steatohepatitis increases plasma retention of sorafenib-glucuronide in a mouse model by altering hepatocyte hopping: 《Acta Pharmaceutica Sinica B》2024年第11期4874-4882,共9页Erica Toth Hui Li Kayla Frost Paxton Sample Joseph Jilek Siennah Greenfield Dahea You Danielle Kozlosky Michael Goedken Mary F.Paine Lauren Aleksunes Nathan Cherrington; by National Institute of General Medical Sciences grant(GM123643,USA);National Institute of Environmental Health Sciences grants(T32ES007148,ES028668,ES006694,and ES007091,USA).; Hepatocyte hopping is the hepatocyte-to-sinusoid-to-hepatocyte shuttling that increases the efficiency of hepatic elimination of xenobiotics. This phenomenon is mediated via efflux of hepatic metabolites by Mrp3 and r...; 关键词：Nonalcoholic steatohepatitis Hepatocytehopping SORAFENIB Sorafenibglucuronide Drug disposition ADME Transport Knockoutmouse

Erythropoietin-induced hepatocyte receptor A2 regulates effect of pyroptosis on gastrointestinal colorectal cancer occurrence and metastasis resistance: 《World Journal of Gastrointestinal Oncology》2024年第9期3781-3797,共17页Yu-Kun Zhang Ran Shi Ruo-Yu Meng Shui-Li Lin Mei Zheng; Scientific Research Nurturing Fund of the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,No.QYPY2020NSFC0609.; Erythropoietin-induced hepatocyte receptor A2(EphA2)is a receptor tyrosine kinase that plays a key role in the development and progression of a variety of tumors.This article reviews the expression of EphA2 in gastroi...; 关键词：Colorectal cancer PYROPTOSIS Erythropoietin-induced hepatocyte receptor A2 Tumor metastasis Drug resistance

Lacticaseibacillus rhamnosus Fmb14 ameliorates hyperuricemia-induced hepatocyte pyroptosis via NLRP3 inflammasome cascade inhibition: 《Food Science and Human Wellness》2024年第4期2174-2186,共13页Hongyuan Zhao Xiaoyu Chen Li Zhang Fanqiang Meng Libang Zhou Zhaoxin Lu Yingjian Lu; Grant support was received from the National Natural Science Foundation of China(32072182).; Hyperuricemia is a high-risk factor for the development of gout and renal fibrosis,but the adverse effects of hyperuricemia on the liver have been seriously neglected.This research investigated the ameliorating effect...; 关键词：Lacticaseibacillus rhamnosus Fmb14 HYPERURICEMIA PYROPTOSIS NLRP3 pathway

Acute liver failure:A clinically severe syndrome characterized by intricate mechanisms: 《World Journal of Hepatology》2024年第7期1067-1069,共3页Ran An Jing-Lin Wang; Acute liver failure presents as a clinical syndrome characterized by swift deterioration and significant mortality rates.Its underlying mechanisms are intricate,involving intricate interplays between various cells.Giv...; 关键词：Acute liver failure HEPATOCYTE MACROPHAGE NECROPTOSIS PYROPTOSIS Ferroptosis

Research on Hepatocyte Regulation of PCSK9-LDLR and Its Related Drug Targets: 《Chinese Journal of Integrative Medicine》2024年第7期664-672,共9页LIU Su-su YU Tong QIAO Yan-fang GU Shu-xiao CHAI Xin-lou; Supported by National Science and Technology Major Special Project Based on Big Data Research and Development of New Chinese Medicine Drugs(No.2019ZX09201004-001-021)。; The prevalence of hyperlipidemia has increased significantly due to genetic, dietary, nutritional and pharmacological factors, and has become one of the most common pathological conditions in humans. Hyperlipidemia ca...; 关键词：HYPERLIPIDEMIA proprotein convertase subtilisin/kexin type 9 low-density lipoprotein receptor intracellular pathway extracellular pathway

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

HEPATOCYTE

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

HEPATOCYTE

检索结果分析

下载全文

用户登录

高级检索检索式检索