supported by National Natural Science Foundation of China(No.82373887 to Qinghua Hu,No.82304506 to Mengze Zhou);Natural Science Foundation of Jiangsu Province(BK20211223 to Qinghua Hu,BK20231022 to Mengze Zhou,China);China Postdoctoral Science Foundation(2022M723513 to Mengze Zhou);the Fundamental Research Funds for the Central Universities(2632024TD01 to Qinghua Hu,2632023GR23 to Mengze Zhou,China).
Acute liver failure(ALF)is lack of broadly approved therapeutic strategy except liver transplantation.As a glycogen metabolic intermediate,UDP-glucose(UDP-G)has been considered to accelerate liver repairment.Neverthel...
The Science Fund for Creative Research Groups of the Natural Science Foundation of Chongqing,China(cstc2021jcyi-cxttx0004);the Chongqing Outstanding Scientists Project(cstc2022ycjh-bgzxm0073);the National Natural Science Foundation of China(32072028,31730063).
Multiple enzymes perform moonlighting functions distinct from their main roles.UDP-glucose epimerases(UGEs),a subclass of isomerases,catalyze the interconversion of UDP-glucose(UDP-Glc)and UDP-galactose(UDP-Gal).We id...
the grants from the National Natural Science Foundation of China(No.32171255);the Fundamental Research Funds for the Central Universities(No.2412020ZD011);Industrialization Cultivation Planning Project of Jilin Provincial Department of Education(No.JJKH20221168CY)。
Glucosylsucroses are potentially useful as additives in cosmetic and pharmaceutical formulations.Although enzymatic synthesis of glucosylsucroses is the most efficient method for their production,the key enzyme that p...
supported by the National Key Research and Development Program of China(Grant No.2018YFA0900700);the Drug Innovation Major Project(2018ZX09711001-006-002);the National Natural Science Foundation of China(Nos.31901021,31921006,and 32071425);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB27020206);the Strategic Biological Resources Service Network Plan of the Chinese Academy of Sciences(Grant No.KFJ-BRP-009);the National Key Research and Development Program of Yunnan Province(2019ZF011-1).
Ginsenoside Compound K(CK)has been recognized as a major functional component that is absorbed into the systemic circulation after oral administration of ginseng.CK demonstrates diverse bioactivities.A phase I clinica...
UDP-glucose hydrolases are a group of relatively little known membrane-bound or periplasmic enzymes found in Salmonella enterica and E. coli. UDP-glucose is an agonist for a specific P2 receptor (P2Y14) found on epith...
Nucleotide sugar transporters (NSTs) are antiporters comprising a gene family that plays a fundamental role in the biosynthesis of complex cell wall polysaccharides and glycoproteins in plants. However, due to the l...