The work was supported by the National Key Research and Development Program of China(2022YFA1106700,2022YFA1104900);the National Natural Science Foundation of China(U23A20535,82025034,82274001,81973392,82204226);Guangdong Basic and Applied Basic Research Foundation(SL2022A04J01943);the Shenzhen Science and Technology Program(KQTD20190929174023858);the 111 project(B16047);the Key Laboratory Foundation of Guangdong Province(2017B030314030);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093).
Our previous study shows that activation of pregnane X receptor(PXR)exerts hepatoprotection against lithocholic acid(LCA)-induced cholestatic liver injury.In this study we investigated whether PXR activation could inh...