疏肝益肾方对激素依赖型乳腺癌患者骨髓抑制作用和血清凋亡Apaf-1、Ki-67、P53的表达及微血管生成的影响  

Effect of Shugan Yishen Decoction(疏肝益肾方)on Bone Marrow Suppression and Serum Apoptosis Apaf-1,Ki-67,P53 Expression and Microangiogenesis in Patients with Hormone-dependent Breast Cancer

作　　者：王晓玲[1] 李江涛[1] 赵莉娜 王成 汪旻琦[1] WANG Xiaoling;LI Jiangtao;ZHAO Lina;WANG Cheng;WANG Minqi(Qinhuangdao Hospital of Traditional Chinese Medicine,Qinhuangdao 066000,Hebei,China)

机构地区：[1]秦皇岛市中医医院,河北秦皇岛066000

出　　处：《辽宁中医药大学学报》2022年第3期128-132,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划(2020369)。

摘　　要：目的探讨疏肝益肾方对激素依赖型乳腺癌患者骨髓抑制作用和血清凋亡蛋白酶活化因子-1(Apaf-1)、增殖细胞核抗原(Ki-67)、肿瘤抑制蛋白P53的表达及微血管生成的影响。方法选择2019年1月—2020年6月于秦皇岛市中医医院治疗的106例激素依赖型乳腺癌患者进行前瞻性研究,根据随机数字表法将纳入研究的病例分为中药联合组和对照组,两组患者行不同治疗方案。对照组服用来曲唑片进行治疗,中药联合组在此基础上服用疏肝益肾方,连续治疗4周。疗程结束后对比两组疗效,骨髓抑制情况及凋亡Apaf-1、Ki-67、P53、血管内皮细胞生长因子(VEGF)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)含量。结果中药联合组疗效分级情况明显优于对照组(P<0.05);治疗后,两组患者的白细胞计数(WBC)、血红蛋白(HB)、血小板计数(PLT)含量相较于治疗前均明显升高(P<0.05),且中药联合组明显高于对照组(P<0.05);治疗后,两组患者的Apaf-1含量相较于治疗前均明显升高(P<0.05),且中药联合组明显高于对照组(P<0.05);两组患者的Ki-67、P53含量相较于治疗前均明显降低(P<0.05),且中药联合组明显低于对照组(P<0.05);治疗后,两组患者的血清VEGF、MMP-2、MMP-9含量相较于治疗前均明显降低(P<0.05),且中药联合组明显低于对照组(P<0.05)。结论疏肝益肾方对激素依赖型乳腺癌患者疗效较好,可有效缓解骨髓抑制效应,提高血清Apaf-1含量,降低Ki-67、P53表达,同时抑制微血管生成。Objective To explore the effect of Shugan Yishen Decoction(疏肝益肾方)on bone marrow suppression,serum apoptosis Apaf-1,Ki-67,P53 expression and microangiogenesis in hormonedependent breast cancer patients.Methods The 106 patients with hormone-dependent breast cancer who were treated in our hospital from January 2019 to June 2020 were selected for a prospective study.According to the random number table method,the included cases were divided into Chinese medicine combination group and control group.Two groups of patients were given different treatment options.The control group took letrozole tablets,and the traditional Chinese medicine combination group took Shugan Yishen Decoction on this basis for 4 weeks of continuous treatment.After the course of treatment,the two groups were compared with curative effect,bone marrow suppression,apoptosis protease activating factor-1(Apaf-1)content,proliferating cell nuclear antigen(Ki-67)content,tumor suppressor protein P53 content,and vascular endothelial cell growth factor(VEGF)content,matrix metalloproteinase-2(MMP-2)content and matrix metalloproteinase-9(MMP-9)content.Results The curative effect classification of the Chinese medicine combination group was significantly better than that of the control group(P<0.05);after treatment,the WBC,HB,and PLT contents of the two groups were significantly higher than those before the treatment(P<0.05),and the Chinese medicine combination group was significantly higher than the control group(P<0.05);after treatment,the Apaf-1 content of the two groups of patients were significantly higher than that before the treatment(P<0.05),and the Chinese medicine combination group was significantly higher than the control group(P<0.05).The Ki-67 and P53 contents of the two groups of patients were significantly lower than before treatment(P<0.05),and the Chinese medicine combination group was significantly lower than the control group(P<0.05);after treatment,the serum VEGF,the contents of MMP-2 and MMP-9 were significantly lower than before

关 键 词：激素依赖型乳腺癌 疏肝益肾方 骨髓抑制 微血管生成作用 

分 类 号：R737.9[医药卫生—肿瘤]