Erythropoietin-induced hepatocyte receptor A2 regulates effect of pyroptosis on gastrointestinal colorectal cancer occurrence and metastasis resistance  

作　　者：Yu-Kun Zhang Ran Shi Ruo-Yu Meng Shui-Li Lin Mei Zheng 

机构地区：[1]Department of Rehabilitation Medicine,The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Jinan 250014,Shandong Province,China [2]Department of Minimally Invasive Comprehensive Treatment of Cancer,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,Shandong Province,China [3]Department of Ana and Intestinal Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2024年第9期3781-3797,共17页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：Scientific Research Nurturing Fund of the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,No.QYPY2020NSFC0609.

摘　　要：Erythropoietin-induced hepatocyte receptor A2(EphA2)is a receptor tyrosine kinase that plays a key role in the development and progression of a variety of tumors.This article reviews the expression of EphA2 in gastrointestinal(GI)colorectal cancer(CRC)and its regulation of pyroptosis.Pyroptosis is a form of programmed cell death that plays an important role in tumor suppression.Studies have shown that EphA2 regulates pyrodeath through various signaling pathways,affecting the occurrence,development and metastasis of GI CRC.The overexpression of EphA2 is closely related to the aggressiveness and metastasis of GI CRC,and the inhibition of EphA2 can induce pyrodeath and improve the sensitivity of cancer cells to treatment.In addition,EphA2 regulates intercellular communication and the microenvironment through interactions with other cytokines and receptors,further influencing cancer progression.The role of EphA2 in GI CRC and its underlying mechanisms provide us with new perspectives and potential therapeutic targets,which have important implications for future cancer treatment.

关 键 词：Colorectal cancer PYROPTOSIS Erythropoietin-induced hepatocyte receptor A2 Tumor metastasis Drug resistance 

分 类 号：R735.34[医药卫生—肿瘤]