IMMUNOMODULATOR

作品数：38被引量：71H指数：5
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The Effect of Prodigiosin Extract from Serratia rubidea against Citrobacter freundii Infection in Mice
《Advances in Microbiology》2024年第8期389-404,共16页Roua Jassim 
This study was prepared due to a lack of studies on the immune modulatory effects of prodigiosin in mice against bacterial infection and the increased demand for natural resources. This study aimed to extract prodigio...
关键词：PRODIGIOSIN IL-6 IL-10 IGM IMMUNOMODULATOR 
Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy被引量：3
《Acta Pharmaceutica Sinica B》2024年第2期765-780,共16页Siqin He Lulu Wang Dongxu Wu Fan Tong Huan Zhao Hanmei Li Tao Gong Huile Gao Yang Zhou 
supported by the National Natural Science Foundation of China(82173762,China);the Key Research and Development Program of Science and Technology Department of Sichuan Province(2022JDJQ0050,China);the Fundamental of Research Funds for the Central Universities.
A major challenge facing photodynamic therapy(PDT) is that the activity of the immuneinduced infiltrating CD8^(+)T cells is subject to the regulatory T lymphocytes(Tregs), leaving the tumor at risk of recurrence and m...
关键词：Photodynamic therapy Immunosuppressive microenvironment IMMUNOMODULATOR Dual-responsive Supramolecularassembly Checkpointblockade 
A Cocktail of Natural Compounds Holds Promise for New Immunotherapeutic Potential in Head and Neck Cancer被引量：2
《Chinese Journal of Integrative Medicine》2024年第1期42-51,共10页Sunil Kumar Asmita Das 
Objective: To obtain detailed understanding on the gene regulation of natural compounds in altering prognosis of head and neck squamous cell carcinomas(HNSC). Methods: Gene expression data of HNSC samples and peripher...
关键词：natural compounds CHEMOPREVENTIVE gene expression head and neck cancer IMMUNOMODULATOR SALIDROSIDE ginsenoside Rd ORIDONIN britanin SCUTELLAREIN 
Application of mannose-modified fullerene immunomodulator selectively polarizes tumor-associated macrophages potentiating antitumor immunity
《Nano Research》2023年第11期12855-12863,共9页Haoyu Wang Lei Li Xinran Cao Mingming Zhen Chunru Wang Chunli Bai 
supported by the National Natural Science Foundation of China(No.92061123).M.M.Z.particularly thanks the Youth Innovation Promotion Association of CAS(No.2022036).
Polarization of tumor associated macrophages(TAMs)has been a promising therapeutic paradigm for tumor.However,how to achieve precise regulation of TAMs and high efficiency of tumor immunotherapy is still a huge challe...
关键词：FULLERENE MANNOSE macrophage targeting tumor-associated macrophage polarization cancer immunotherapy 
M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator被引量：10
《Bioactive Materials》2023年第10期273-283,共11页Yili Wang Qiushui Lin Hao Zhang Sicheng Wang Jin Cui Yan Hu Jinlong Liu Mengmeng Li Kun Zhang Fengjin Zhou Yingying Jing Zhen Geng Jiacan Su 
supported by the Integrated Project of Major Research Plan of National Natural Science Foundation of China(92249303);Key Project of the National Natural Science Foundation of China(82230071);National Natural Science Foundation of China(32101084,82202344).
Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture healing.Macrophages play a key role in the process of fracture healing by undergoing polarization into either M1 or M2 subtypes,...
关键词：M2-exosomes Diabetic fracture healing Osteoimmune microenvironment Macrophage polarization PI3K/AKT signaling pathway 
Naringenin is a Potential Immunomodulator for Inhibiting Liver Fibrosis by Inhibiting the cGAS-STING Pathway被引量：8
《Journal of Clinical and Translational Hepatology》2023年第1期26-37,共12页Li Chen Siwei Xia Shuqi Wang Yuanyuan Zhou Feixia Wang Zhanghao Li Yang Li Desong Kong Zili Zhang Jiangjuan Shao Xuefen Xu Feng Zhang Shizhong Zheng 
supported by the National Natural Science Foundation of China (82073914 and 81870423);the Jiangsu Province Traditional Chinese Medicine Science and Technology Development Plan Project (QN202112);the Joint Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and Yangtze River Pharmaceutical (JKLPSE202005).
Background and Aims:Naringenin is an anti-inflammatory flavonoid that has been studied in chronic liver disease.The mechanism specific to its antifibrosis activity needs further investigation This study was to focused...
关键词：Liver fibrosis cGAS NARINGENIN INFLAMMATION Hepatic stellate cells 
Anti-leishmanial,immunomodulatory and anti-oxidative activity of quercetin against cutaneous leishmaniasis caused by Leishmania major被引量：3
《Asian Pacific Journal of Tropical Biomedicine》2023年第1期26-34,共9页Ahmad Oryan Effat Bemani Somayeh Bahrami 
The study was financially supported by INSF(grant number 96006039).
Objective:To evaluate the in vitro and in vivo efficacy of quercetin and its immunomodulatory and anti-oxidative activity against Leishmania major(L.major).Methods:L.major promastigotes and amastigotes were incubated ...
关键词：Leishmania major Cutaneous leishmaniosis Wound healing QUERCETIN IMMUNOMODULATOR 
Pulmonary cryptococcosis after immunomodulator treatment in patients with Crohn’s disease:Three case reports被引量：1
《World Journal of Gastroenterology》2023年第4期758-765,共8页Yan-Fei Fang Xiang-Han Cao Ling-Ya Yao Qian Cao 
BACKGROUND Corticosteroids and anti-tumor necrosis factorαmAbs are widely used to treat Crohn's disease(CD).However,one disadvantage of this treatment is impairment of normal immune function,leading to an increased r...
关键词：Crohn’s disease IMMUNOMODULATOR INFLIXIMAB Opportunistic infections Pulmonary cryptococcosis Case report 
The immunity-promoting activity of porcine placenta in mice as an immunomodulator for functional foods
《Food Science and Human Wellness》2022年第6期1475-1481,共7页Zhiwei Zhou Dan Wang Wei Liu Lang He Pengkuan Liang Junli Hao Qun Sun 
supported by grants from the National Key Research and Development Projects(2019YFE0103800);Scientific Research Project of Sichuan Provincial Health Department(No.18PJ586);Research and Innovation Team Project of Chengdu Medical College(No.CYTD16-04)。
This study was to explore the immunity-promoting activity of porcine placenta as a potential raw material for functional foods.Porcine placenta was subjected to the analysis for its bioactive substances,and their immu...
关键词：Porcine placenta Immunity promoting activity Phagocytic rate CYTOKINES Functional foods 
Fetuin-A is an immunomodulator and a potential therapeutic option in BMP4-dependent heterotopic ossification and associated bone mass loss被引量：1
《Bone Research》2022年第4期867-881,共15页Chen Kan Jiazhao Yang Haitao Fan Yuanjuan Dai Xingxing Wang Rui Chen Jia Liu Xiangyue Meng Wei Wang Guiling Li Jiao Zhou Ya Zhang Wanbo Zhu Shiyuan Fang Haiming Wei Hong Zheng Siying Wang Fang Ni 
supported by the National Key Research and Development Program of China(reference number 2019YFA0801800);the Natural Science Foundation of China(reference numbers 32070916,82102573,8157152,81472087,81670097 and 81870085);the Natural Science Foundation of Anhui Province(reference numbers 1508085MC45 and 1908085QH359).
Heterotopic ossification(HO)is the abnormal formation of bone in extraskeletal sites.However,the mechanisms linking HO pathogenesis with bone mass dysfunction remain unclear.Here,we showed that mice harboring injury-i...
关键词：PD1 THERAPEUTIC inhibited 
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