Pulmonary cryptococcosis after immunomodulator treatment in patients with Crohn’s disease:Three case reports  

作　　者：Yan-Fei Fang Xiang-Han Cao Ling-Ya Yao Qian Cao 

机构地区：[1]Department of Gastroenterology,Inflammatory Bowel Disease Center,Sir Run Shaw Hospital,College of Medicine Zhejiang University,Hangzhou 310016,Zhejiang Province,China

出　　处：《World Journal of Gastroenterology》2023年第4期758-765,共8页世界胃肠病学杂志（英文版）

摘　　要：BACKGROUND Corticosteroids and anti-tumor necrosis factorαmAbs are widely used to treat Crohn's disease(CD).However,one disadvantage of this treatment is impairment of normal immune function,leading to an increased risk of infection.Cryptococcus infection is an opportunistic infection that occurs mainly in immunocompromised patients and poses a significant diagnostic challenge in patients with CD.CASE SUMMARY Here,we report three cases of pulmonary cryptococcosis in patients with CD after receiving immunomodulatory treatment.The patients presented with no or mild respiratory symptoms.Chest computed tomography scans revealed pulmonary nodules in the unilateral or bilateral lobes.Diagnoses were made using pathological examination and metagenomic sequencing.The patients were treated with fluconazole 400 mg once daily for 1 to 6 mo,and symptoms were resolved.Literature searches were conducted in PubMed,Web of Science,and Embase to retrieve previously reported cases and summarize patient characteristics.CONCLUSION The incidence of cryptococcus infection has increased along with immunomodulator use.Clinical vigilance is required for early identification and standardized treatment.

关 键 词：Crohn’s disease IMMUNOMODULATOR INFLIXIMAB Opportunistic infections Pulmonary cryptococcosis Case report 

分 类 号：R563[医药卫生—呼吸系统]