ORIDONIN

作品数：47被引量：278H指数：11
导出分析报告
相关领域：医药卫生更多>>
相关作者：李翔曲桂芹乔雪吴婉莹叶敏更多>>
相关机构：中山大学郑州大学西北师范大学中国医科大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金中国博士后科学基金湖北省自然科学基金国家重点实验室开放基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Network Pharmacology and in vitro Experimental Verification on Intervention of Oridonin on Non-Small Cell Lung Cancer
《Chinese Journal of Integrative Medicine》2025年第4期347-356,共10页CHANG Ke ZHU Li-fei WU Ting-ting ZHANG Si-qi YU Zi-cheng 
Objective:To explore the key target molecules and potential mechanisms of oridonin against non-small cell lung cancer(NSCLC).Methods:The target molecules of oridonin were retrieved from Similarity Ensemble Approach(SE...
关键词：ORIDONIN Chinese medicine non-small cell lung cancer network pharmacology molecular docking in vitro experiments 
The combination of SLC7A11 inhibitor and oridonin synergistically inhibits cervical cancer cell growth by decreasing the NADPH/NADP^(+) ratio
《Genes & Diseases》2025年第1期137-140,共4页Yajie Liu Pengxing He Xubin Ma Yingqi Tian Yu Zhang Yang Wang Yingjie Jia Hongmin Liu Ying Liu Yichao Xu 
supported by the National Key Research and Development Project(China)(No.2018YFE0195100);the National Natural Science Foundation of China(No.82020108030);the Key Scientific Research Projects in Colleges and Universities of Henan Province,China(No.23A350007).
SLC7A11,as the core component of system xc,protects cancer cells from oxidative-stress-induced cell death like ferroptosis by mediating cystine uptake.Recent studies revealed that SLC7A11 is widely overexpressed in va...
关键词：cervical HERBAL synergistic 
An iron-based metal-organic framework nanoplatform for enhanced ferroptosis and oridonin delivery as a comprehensive antitumor strategy
《Acta Pharmaceutica Sinica B》2024年第9期4073-4086,共14页Mengru Cai Tingting Fu Rongyue Zhu Panxiang Hu Jiahui Kong Shilang Liao Yuji Du Yongqiang Zhang Changhai Qu Xiaoxv Dong Xingbin Yin Jian Ni 
the Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine(No.CACM-QNRC2-A03,China);the Beijing Natural Science Foundation(No.7202121,China);the National Natural Science Foundation of China(No.81703715).
Ferroptosis is a recently discovered pathway for regulated cell death pathway.However,its efficacy is affected by limited iron content and intracellular ion homeostasis.Here,we designed a metalorganic framework(MOF)-b...
关键词：Metal-organic frameworks IMMUNOTHERAPY Self-amplifying ferroptosis Photodynamic therapy Chemodynamic therapy ORIDONIN Fused cell membrane coating Metabolization 
Selenium Regulates Antioxidant Capacities and Diterpenoid Biosynthesis in the Medicinal Plant Isodon rubescens
《Phyton-International Journal of Experimental Botany》2024年第7期1705-1716,共12页Fenglan Zhao Shuwen Wu Xue Meng Jianping Xue Yongbo Duan 
supported by the Key Project of Natural Science Research for Colleges and Universities in Anhui Province(2023AH050345,KJ2021A0533);the Excellent Scientific Research and Innovation Team of Universities in Anhui Province(2022AH010029).
Dōng líng căo,the dried aboveground parts of Isodon rubescens(Hemls.)Hara.,is commonly consumed as a med-icinal decoction or tea beverage.Natural beverages can be an important source of human dietary selenium(Se).Ho...
关键词：FLAVONOIDS ORIDONIN physiological indicators quantitative real-time PCR SELENIUM 
A Cocktail of Natural Compounds Holds Promise for New Immunotherapeutic Potential in Head and Neck Cancer被引量：2
《Chinese Journal of Integrative Medicine》2024年第1期42-51,共10页Sunil Kumar Asmita Das 
Objective: To obtain detailed understanding on the gene regulation of natural compounds in altering prognosis of head and neck squamous cell carcinomas(HNSC). Methods: Gene expression data of HNSC samples and peripher...
关键词：natural compounds CHEMOPREVENTIVE gene expression head and neck cancer IMMUNOMODULATOR SALIDROSIDE ginsenoside Rd ORIDONIN britanin SCUTELLAREIN 
Oridonin restores hepatic lipid homeostasis in an LXRa-ATGL/EPT1 axis-dependent manner被引量：1
《Journal of Pharmaceutical Analysis》2023年第11期1281-1295,共15页Yulian Chen Huanguo Jiang Zhikun Zhan Jindi Lu Tanwei Gu Ping Yu Weimin Liang Xi Zhang Shilong Zhong Lan Tang 
supported by the National Natural Science Foundation of China(Grant No.:81973388);Marine Economy Development Project of Guangdong Province(Project No.:GDNRC[2021]52);the Key Research and Development Program of Guangdong Province(Program No.:2020B1111030005).
Hepatosteatosis is characterized by abnormal accumulation of triglycerides(TG),leading to prolonged and chronic inflammatory infiltration.To date,there is still a lack of effective and economical therapies for hepatos...
关键词：ORIDONIN Lipid homeostasis TG reduction PE elevation LXRa-ATGL/EPT1 axis 
Oridonin inhibits SARS-CoV-2 replication by targeting viral proteinase and polymerase被引量：1
《Virologica Sinica》2023年第3期470-479,共10页Zherui Zhang Hongqing Zhang Yanan Zhang Qiuyan Zhang Qiaojie Liu Yanyan Hu Xiaoling Chen Jing Wang Yujia Shi Chenglin Deng Peng Gong Bo Zhang Xiaodan Li Bing Zhu Hanqing Ye 
the Creative Research Group Program of Natural Science Foundation of Hubei Province(2022CFA021);the China Postdoctoral Science Foundation(2022M720895);the National Natural Science Foundation of China(3210011 and 32200132);the Natural Science Foundation of Hubei Province,China(2017CFB535).
COVID-19 has become a global public health crisis since its outbreak in China in December 2019.Currently there are few clinically effective drugs to combat SARS-CoV-2 infection.The main protein(M^(pro)),papain-like pr...
关键词：SARS-CoV-2 ORIDONIN ANTIVIRAL Protease inhibitor 
Modularly designed peptide-based nanomedicine inhibits angiogenesis to enhance chemotherapy for post-surgical recurrence of esophageal squamous cell carcinomas
《Nano Research》2023年第5期7347-7354,共8页Yingqiu Qi Jinxiu Shen Chen Liu Anni Du Mengdie Chen Xiaocao Meng Hui Wang Saiyang Zhang Lirong Zhang Zhongjun Li Yike Li Yale Yue Huan Min 
the National Natural Science Foundation of China(Nos.32000998 and U2004123);the Young Elite Scientists Sponsorship Program by Henan Association for Science and Technology(No.2022HYTP046);the China Postdoctoral Science Foundation(Nos.2019TQ0285,2019M662513,2021TQ0298,and 2022TQ0296).
Traditional surgical treatment is difficult to thoroughly remove esophageal squamous cell carcinomas(ESCC),postoperative recurrence caused by residual tumor cells is a critical factor in the poor prognosis.Since surgi...
关键词：esophageal squamous cell carcinomas peptide-based nanomedicine ANTI-ANGIOGENESIS ORIDONIN CHEMOTHERAPY 
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy被引量：5
《Acta Pharmacologica Sinica》2023年第4期726-740,共15页Lei Li Jing-jing Song Meng-xue Zhang Hui-wen Zhang Hai-yan Zhu Wei Guo Cai-long Pan Xue Liu Lu Xu Zhi-yuan Zhang 
supported by the National Natural Science Foundation of China(Grants 82071209 and 81771171 to ZYZ).
Neuronal loss is a primary factor in determining the outcome of ischemic stroke.Oridonin(Ori),a natural diterpenoid compound extracted from the Chinese herb Rabdosia rubescens,has been shown to exert anti-inflammatory...
关键词：ischemic stroke ORIDONIN RIPK3 MITOPHAGY apoptosis transient middle cerebral artery occlusion 
A chromosome-level genome assembly reveals that tandem-duplicated CYP706V oxidase genes control oridonin biosynthesis in the shoot apex of Isodon rubescens被引量：4
《Molecular Plant》2023年第3期517-532,共16页Yuwei Sun Jie Shao Haili Liu Hua Wang Guangyi Wang Jianhua Li Yaping Mao Zhuo Chen Ke Ma Lin Xu Yong Wang 
funded by the National Key R&D Program of China(2018YFA0900600);the National Natural Science Foundation of China(32070328,22077129,and 41876084),the Program of Shanghai Academic Research Leader(20XD1404400);the Strategic Priority Research Program“Molecular Mechanism of Plant Growth and Development”of CAS(XDB27020202);the Construction of the Registry and Database of Bioparts for Synthetic Biology of the Chinese Academy of Sciences(ZSYS-016),the International Partnership Program of the Chinese Academy of Sciences(153D31KYSB20170121),Derivative Bank of Chinese Biological Resources(KFJ-BRP-009-002);the National Key Laboratory of Plant Molecular Genetics,SIPPE,CAS.Y.S.is supported by the Foundation of Youth Innovation Promotion Association of the Chinese Academy of Sciences.
The ent-kaurenoids(e.g.,oridonin and enmein)from the Isodon genus(Lamiaceae)are one class of diterpenoids with rich structural diversity and intriguing pharmaceutical activity.In contrast to the well-established gibbe...
关键词：oridonin biosynthesis Isodon rubescens genome sequencing CYP706 oxidases diterpenoid diversity 
全选清除导出
共5页<12345>
检索报告 对象比较 聚类工具 使用帮助 返回顶部