Modularly designed peptide-based nanomedicine inhibits angiogenesis to enhance chemotherapy for post-surgical recurrence of esophageal squamous cell carcinomas  

作　　者：Yingqiu Qi Jinxiu Shen Chen Liu Anni Du Mengdie Chen Xiaocao Meng Hui Wang Saiyang Zhang Lirong Zhang Zhongjun Li Yike Li Yale Yue Huan Min 

机构地区：[1]Department of Pharmacology,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,China [2]Henan Institute of Advanced Technology,Zhengzhou University,Zhengzhou 450001,China [3]State Key Laboratory of Esophageal Cancer Prevention&Treatment,Zhengzhou 450001,China [4]College of Chemistry,Institute of Green Catalysis,Zhengzhou University,Henan 450001,China

出　　处：《Nano Research》2023年第5期7347-7354,共8页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.32000998 and U2004123);the Young Elite Scientists Sponsorship Program by Henan Association for Science and Technology(No.2022HYTP046);the China Postdoctoral Science Foundation(Nos.2019TQ0285,2019M662513,2021TQ0298,and 2022TQ0296).

摘　　要：Traditional surgical treatment is difficult to thoroughly remove esophageal squamous cell carcinomas(ESCC),postoperative recurrence caused by residual tumor cells is a critical factor in the poor prognosis.Since surgical resection promotes the local angiogenesis at the tumor site,further exacerbating the proliferation and invasion of residual tumor cells,it is urgent to inhibit angiogenesis after surgery.Here,a functional peptide-based nanomedicine was obtained from peptide–drug conjugates,which are composed of a hydrophilic targeting motif(vascular endothelial growth factor family and their receptors(VEGFR)targeting peptide for anti-angiogenesis),an ester-linked hydrophobic oridonin(ORI).The nanomedicine exhibits esterase-catalyzed disassembly and drug release,significantly enhanced the anti-tumor efficacy of chemotherapeutics in a postoperative tumor recurrence model through synergistic anti-angiogenic strategies.This study provides an integrated solution for anti-angiogenesisaugmented chemotherapy and demonstrates the encouraging potential for postoperative treatment.

关 键 词：esophageal squamous cell carcinomas peptide-based nanomedicine ANTI-ANGIOGENESIS ORIDONIN CHEMOTHERAPY 

分 类 号：R735.1[医药卫生—肿瘤]