Insulin therapy in type 2 diabetes: Insights into clinical efficacy, patient-reported outcomes, and adherence challenges  

作　　者：Mahmoud Emad-Eldin Gehan F Balata Eman A Elshorbagy Mona S Hamed Mohamed S Attia 

机构地区：[1]Department of Pharmacy Practice,Faculty of Pharmacy,Zagazig University,Zagazig HFQM+872,Al-Sharqia Governorate,Egypt [2]Department of Pharmacy Practice,Faculty of Pharmacy,Heliopolis University,Cairo 44519,Egypt [3]Department of Pharmaceutics,Faculty of Pharmacy,Zagazig University,Zagazig 44519,Al-Sharqia Governorate,Egypt [4]Department of Internal Medicine,Faculty of Medicine,Zagazig University,Zagazig 44519,Al-Sharqia Governorate,Egypt [5]Department of Community at Faculty of Medicine,Zagazig University,Zagazig 44519,Al-Sharqia Governorate,Egypt

出　　处：《World Journal of Diabetes》2024年第5期828-852,共25页世界糖尿病杂志（英文版）（电子版）

摘　　要：Insulin therapy plays a crucial role in the management of type 2 diabetes as the disease progresses.Over the past century,insulin formulations have undergone significant modifications and bioengineering,resulting in a diverse range of available insulin products.These products show distinct pharmacokinetic and pharmacodynamic profiles.Consequently,various insulin regimens have em-erged for the management of type 2 diabetes,including premixed formulations and combinations of basal and bolus insulins.The utilization of different insulin regimens yields disparate clinical outcomes,adverse events,and,notably,patient-reported outcomes(PROs).PROs provide valuable insights from the patient’s perspective,serving as a valuable mine of information for enhancing healthcare and informing clinical decisions.Adherence to insulin therapy,a critical patient-reported outcome,significantly affects clinical outcomes and is influenced by multiple factors.This review provides insights into the clinical effectiveness of various insulin preparations,PROs,and factors impacting insulin therapy adherence,with the aim of enhancing healthcare practices and informing clinical decisions for individuals with type 2 diabetes.

关 键 词：ADHERENCE DIABETES INSULIN Patient-reported outcomes PHARMACOKINETIC PHARMACODYNAMIC 

分 类 号：R587.1[医药卫生—内分泌]