JAK-STAT

作品数：171被引量：756H指数：14
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相关领域：医药卫生更多>>
相关作者：笪宇蓉黄云龙武利军杨洁张日更多>>
相关机构：青岛大学天津医科大学武汉大学成都中医药大学更多>>
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阿布昔替尼治疗6例激素诱导的玫瑰痤疮样皮炎疗效观察
《皮肤科学通报》2024年第6期660-665,共6页孟潇琦 刘亭微 许阳 
目的探讨高选择性JAK1抑制剂治疗激素诱导的玫瑰痤疮样皮炎(steroid-induced rosacea-like dermatitis,SIRD)的临床效果及安全性。方法纳入本院门诊SIRD患者6例,使用口服JAK1抑制剂阿布昔替尼治疗,起始剂量100 mg/d,每两周随访观察疗效...
关键词：JAK-STAT JAK1抑制剂 阿布昔替尼 激素诱导的玫瑰痤疮样皮炎 
Macrophages exploit the mannose receptor and JAK-STAT1- MHC-Ⅱ pathway to drive antigen presentation and the antimycobacterial immune response after BCG vaccination被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第8期1130-1144,共15页Ying Zhang Dandan Xu Qi Nie Jing Wang Dan Fang Yan Xie Huang Xiong Qin Pan Xiao-Lian Zhang 
supported by the grants from the National Key R&D Program of China(Nos.2022YFA1303500 and 2018YFA0507603);the National Natural Science Foundation of China(Nos.82230078,22077097,91740120,21721005,82272978 and 21572173);the Fundamental Research Funds for the Central Universities.
Tuberculosis(TB),caused by Mycobacterium tuberculosis(M.tb),remains one of the leading causes of fatal infectious diseases worldwide.The only licensed vaccine,Mycobacterium bovis Bacillus Calmette-Guérin(BCG),has var...
关键词：BCG vaccine mannose receptor MACROPHAGE antigen presentation 
Electrical stimulation with polypyrrole-coated polycaprolactone/silk fibroin scaffold promotes sacral nerve regeneration by modulating macrophage polarisation
《Biomaterials Translational》2024年第2期157-174,共18页Haofeng Cheng Jun Bai Xingyu Zhou Nantian Chen Qingyu Jiang Zhiqi Ren Xiangling Li Tianqi Su Lijing Liang Wenli Jiang Yu Wang Jiang Peng Aijia Shang 
supported by Capital’s Funds for Health Improvement and Research(No.CFH2022-2-5022).
Peripheral nerve injury poses a great threat to neurosurgery and limits the regenerative potential of sacral nerves in the neurogenic bladder.It remains unknown whether electrical stimulation can facilitate sacral ner...
关键词：electrical stimulation JAK-STAT signalling pathway macrophage polarisation peripheral nerve regeneration POLYPYRROLE sacral nerve injury 
Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK-STAT pathway
《Acta Pharmaceutica Sinica B》2024年第6期2554-2566,共13页Jingyi Tan Jiayu Zhang Cheng Hu Gongwei Wang Qianyao Ren Chaoqun Wang Jia Dan Zexin Zeng Jun Hu Wenbo Zhu Jiankai Liang Jing Cai Ying Liu Guangmei Yan Yuan Lin 
supported by National Key R&D Program of China(No.2021YFA0909800,China);Guangdong Basic and Applied Basic Research Foundation(Nos.2022B1515020056,2021A1515011881,2023A1515010737,China);Leading team for entrepreneurship in Guangzhou,Guangdong Province(No.201809020004,China);Fundamental Research Funds for the Central Universities(No.22ykqb12,China);Pioneering talents project of Guangzhou Development Zone,Guangdong Province(2020-L036,China);Natural Science Foundation of Guangdong Province(No.2022A1515011056,China).
Oncolytic viruses(OVs),a group of replication-competent viruses that can selectively infect and kill cancer cells while leaving healthy cells intact,are emerging as promising living anticancer agents.Unlike traditiona...
关键词：PHARMACOKINETICS Oncolytic virus JAK-STAT ANTICANCER 
JAK-STAT信号通路抑制剂在皮肤病治疗中的应用被引量：1
《中国中西医结合皮肤性病学杂志》2024年第2期188-191,共4页陈立新 廉佳 王莹 李钦峰 
Janus激酶-信号转导及转录激活因子(JAK-STAT)信号通路可参与众多炎症性皮肤病的发病,大量临床研究证明,该通路抑制剂可用于银屑病、特应性皮炎(AD)、斑秃、白癜风等皮肤病的治疗。本文就其在上述疾病发病机制中的作用及应用进展进行综述。
关键词：Janus激酶-信号转导及转录激活因子 JAK抑制剂 皮肤科 银屑病 特应性皮炎 斑秃 白癜风 
Corrigendum to“3Cpro of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation”[Virol Sin 38(2023)387–397]
《Virologica Sinica》2024年第2期351-354,共4页Xiangju Wu Lei Chen Chao Sui Yue Hu Dandan Jiang Fan Yang Laura C.Miller Juntong Li Xiaoyan Cong Nataliia Hrabchenko Changhee Lee Yijun Du Jing Qi 
Due to our negligence,the original version of this article,published online on Mar 14,2023,contained some mistakes in several Figs.In Fig.2D,the positions of the bands for protein 3A and 3B were incorrectly shifted.Th...
关键词：STAT1 FMDV BANDS 
Identification and functional analysis of CG3526 in spermatogenesis of Drosophila melanogaster
《Insect Science》2024年第1期79-90,共12页Qihao Hu Yanhong Xiao Runnan Wei Ting Tang Liang Wen Yuzhen Lu Xiao-Qiang Yu 
This work was supported by the National Natural Science Foundation of China(No.31970474 and No.32272606);China Postdoctoral Science Foundation(No.2022M721219).
Spermatogenesis is a critical part of reproduction in insects;however,its molecular mechanism is still largely unknown.In this study,we identified a testis-specific gene CG3526 in Drosophila melanogaster.Bioinformatic...
关键词：CG3526 JAK-STAT SPERMATOGENESIS STAT92E TESTIS 
A multifunctional nanoaggregate-based system for detection of rheumatoid arthritis via Optoacoustic/NIR-Ⅱ fluorescent imaging and therapy via inhibiting JAK-STAT/NF-κB/NLRP3 pathways
《Aggregate》2024年第1期353-366,共14页Junjie Chen Longqi Chen Zunpan She Fang Zeng Shuizhu Wu 
NSFC,Grant/Award Numbers:22274057,21875069,21788102;Guangdong Provincial Basic and Applied Basic Research Fund Regional Joint Fund Project(Youth Fund Project),Grant/Award Number:2022A1515110842;Chinese Postdoctoral Science Foundation,Grant/Award Number:2022M711194。
Rheumatoid arthritis(RA)is a debilitating autoimmune disease that causes chronic pain and serious complications,presenting a significant challenge to treat.Promising approaches for treating RA involve signaling pathwa...
关键词：aggregation-induced emission dual-stimuli response multispectral optoacoustic tomography imaging multitargeting NIR-II fluorescence imaging rheumatoid arthritis 
Janus激酶-信号转导及转录激活因子信号通路抑制剂在白癜风治疗中的新进展被引量：1
《中华皮肤科杂志》2024年第1期71-75,共5页古丽孜巴·图尔荪 屈园园 
中国研究型医院学会科研课题 (Y2021FH-PFK06)。
近年来,随着对白癜风发病机制的深入研究,Janus激酶(JAK)-信号转导及转录激活因子(STAT)信号通路越来越受到关注.本文综述了JAK-STAT信号通路在白癜风发生过程中的作用,并回顾了目前正在研究或已用于治疗白癜风的JAK-STAT抑制剂.
关键词：白癜风 Janus激酶类 STAT转录因子类 JAK-STAT抑制剂 治疗 
Reactive oxygen species and nitric oxide scavenging nanoparticles alleviating rheumatoid arthritis through adjusting the seeds and growing soils
《Acta Pharmaceutica Sinica B》2023年第12期5016-5029,共14页Peng Hua Ruifeng Liang Yanbei Tu Yuying Yin Man-Kay Law Meiwan Chen 
supported by the National Natural Science Foundation of China(51922111,82204724);the Science and Technology Development Fund,Macao SAR(File no.0124/2019/A3 and SKL-QRCM(UM)-2023-2025,China);the University of Macao(File no.MYRG2022-00203-ICMS,China).
Normalizing inflamed soils including reactive oxygen species(ROS),nitric oxide(NO),cellfree DNA,and regulating infammation-related seeds such as macrophages,neutrophils,fibroblasts,represent a promising strategy to ma...
关键词：BILIRUBIN O-PHENYLENEDIAMINE Notopterol ROS and NO scavenging JAK-STATpathway ANTI-INFLAMMATORY Cartilage protection Rheumatoid arthritis 
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