supported by the National Natural Sciences Foundation of China(No.32102639 and 32072831);the National Key Research and Development Program of China(No.2021YFD1800300);the Gansu Science Foundation for Distinguished Young Scholars(No.21JR7RA026);the Earmarked Fund for CARS-35,the Strategic Priority Research Program of the National Center of Technology Innovation for Pigs(No.NCTIP-XD/C03);the Science and Technology Major Project of Gansu Province(No.22ZD6NA001);the Natural Science Foundation of Gansu Province(No.22JR5RA034 and 23JRRA549);the open competition program of top ten critical priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province(No.2023SDZG02);the Fundamental Research Funds for the Central Universities(No.lzujbky-2022-ey20).
Foot-and-mouth disease(FMD)is a highly contagious and economically important disease,which is caused by the FMD virus(FMDV).Although the cell receptor for FMDV has been identified,the specific mechanism of FMDV intern...