ENDOSOME

作品数：26被引量：87H指数：6
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相关领域：医药卫生生物学更多>>
相关机构：中国医学科学院北京协和医学院更多>>
相关期刊：《Open Journal of Genetics》《Science China(Life Sciences)》《中国组织化学与细胞化学杂志》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Biogenesis of Rab14-positive Endosome Buds at Golgi-endosome Contacts by the RhoBTB3-SHIP164-Vps26B Complex
《Current Medical Science》2024年第4期864-866,共3页Jing-ru WANG Jun-yao ZHANG Wei-Ke JI 
As one of the basic processes of cellular activity,endocytosis sorting determines the fate of many proteins on the endosomal membranes,thus affecting a variety of important cellular processes,such as nutrient uptake,c...
关键词：HOMEOSTASIS ENDO sorting 
KIF5B-mediated internalization of FMDV promotes virus infection
《Virologica Sinica》2024年第3期378-389,共12页Wei Zhang Fan Yang Yang Yang Weijun Cao Wenhua Shao Jiali Wang Mengyao Huang Zhitong Chen Xiaoyi Zhao Weiwei Li Zixiang Zhu Haixue Zheng 
supported by the National Natural Sciences Foundation of China(No.32102639 and 32072831);the National Key Research and Development Program of China(No.2021YFD1800300);the Gansu Science Foundation for Distinguished Young Scholars(No.21JR7RA026);the Earmarked Fund for CARS-35,the Strategic Priority Research Program of the National Center of Technology Innovation for Pigs(No.NCTIP-XD/C03);the Science and Technology Major Project of Gansu Province(No.22ZD6NA001);the Natural Science Foundation of Gansu Province(No.22JR5RA034 and 23JRRA549);the open competition program of top ten critical priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province(No.2023SDZG02);the Fundamental Research Funds for the Central Universities(No.lzujbky-2022-ey20).
Foot-and-mouth disease(FMD)is a highly contagious and economically important disease,which is caused by the FMD virus(FMDV).Although the cell receptor for FMDV has been identified,the specific mechanism of FMDV intern...
关键词：FMDV VP1 protein KIF5B ENDOSOME CLATHRIN 
Calmodulin-like 5 promotes PEDV replication by regulating late-endosome synthesis and innate immune response被引量：1
《Virologica Sinica》2024年第3期501-512,共12页Wen-Jun Tian Xiu-Zhong Zhang Jing Wang Jian-Feng Liu Fu-Huang Li Xiao-Jia Wang 
supported by the National Key R&D Program of China(2023YFD1801100);the National Natural Science Foundation of China(32172821);a CAU-Grant for the Prevention and Control of Immunosuppressive Disease in Animals(CAU-G-PCIDA)of the China Agricultural University.
The infection caused by porcine epidemic diarrhea virus(PEDV)is associated with high mortality in piglets worldwide.Host factors involved in the efficient replication of PEDV,however,remain largely unknown.Our recent ...
关键词：Porcine epidemic diarrhea virus(PEDV) EF-hand protein calmodulin-like 5(CALML5) Late endosomes Innate immune response 
Stay in touch with the endoplasmic reticulum被引量：2
《Science China(Life Sciences)》2024年第2期230-257,共28页Sha Sun Gan Zhao Mingkang Jia Qing Jiang Shulin Li Haibin Wang Wenjing Li Yunyun Wang Xin Bian Yan G.Zhao Xun Huang Ge Yang Huaqing Cai Jose C.Pastor-Pareja Liang Ge Chuanmao Zhang Junjie Hu 
supported by the National Natural Science Foundation of China(92254305);supported by the National Natural Science Foundation of China(92254305,91854204,32130026);supported by National Natural Science Foundation of China(92254302,32225013,32130023);supported by the National Natural Science Foundation of China(91954201,31971289);supported by grants from the National Natural Science Foundation of China(91954207);supported by the National Natural Science Foundation of China(32170753);supported by the National Natural Science Foundation of China(32170692,92154001);supported by grants from the National Natural Science Foundation of China(92254303,32170701);supported by grants from the National Natural Science Foundation of China(32101000,32271273);the Strategic Priority Research Program(XDB39000000);Project for Young Scientists in Basic Research(YSBR-075)of the Chinese Academy of Sciences;the National Key Research and Development Program of China(2021YFA1300800);National Key Research and Development Program of China(2021YFA0804802,2019YFA0508602);Beijing Natural Science Foundation(JQ20028);New Cornerstone Science Foundation(Xplorer Prize);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37020304);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37040402);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA24030205);the National Key Research and Development Program of China(2021YFA1300301);the National Key Research and Development Program of China(2018YFA0506902);the Fundamental Research Funds for the Central Universities(63213104,63223043);the Talent Training Project at Nankai University(035-BB042112);supported by the Beijing Municipal Science&Technology Commission(5202022)。
The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic cells.As a result,it engages a variety of organelles by est...
关键词：endoplasmic reticulum nuclear envelope MITOCHONDRIA Golgi apparatus ENDOSOME LYSOSOME lipid droplets AUTOPHAGOSOME plasma membrane membrane contact site 
Lipid carriers for mRNA delivery被引量：7
《Acta Pharmaceutica Sinica B》2023年第10期4105-4126,共22页Wanting Zhang Yuxin Jiang Yonglong He Hamza Boucetta Jun Wu Zhongjian Chen Wei He 
supported by the National Natural Science Foundation of China(Nos.81872823,82073782);the Double First-Class(CPU2018PZQ13,China)of the CPU;the Shanghai Science and Technology Committee(19430741500,China);Natural Science Foundation of the Jiangsu Higher Education Institutions of China(21KJA320003);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine(zdsys-202103)。
Messenger RNA(mRNA)is the template for protein biosynthesis and is emerging as an essential active molecule to combat various diseases,including viral infection and cancer.Especially,mRNA-based vaccines,as a new type ...
关键词：MRNA Lipid carriers Drug delivery Endosome escape NANOPARTICLES Encapsulation efficiency VACCINE COVID-19 
Converging links between adult-onset neurodegenerative Alzheimer’s disease and early life neurodegenerative neuronal ceroid lipofuscinosis?被引量：1
《Neural Regeneration Research》2023年第7期1463-1471,共9页Marcel Klein Guido Hermey 
supported by the Deutsche Forschungsgemeinschaft(DFG,425373668,HE 3220/4-1)(to GH).
Evidence from genetics and from analyzing cellular and animal models have converged to suggest links between neurodegenerative disorders of early and late life.Here,we summarize emerging links between the most common ...
关键词：Alzheimer’s disease autophagy Batten disease CLN3 disease dementia ENDOSOME LYSOSOME neurodegeneration neuronal ceroid lipofuscinosis PRESENILIN 
siRNA-functionalized lanthanide nanoparticle enables efficient endosomal escape and cancer treatment被引量：3
《Nano Research》2022年第10期9160-9168,共9页Chanchan Yu Kun Li Lin Xu Bo Li Chunhui Li Shuai Guo Ziyue Li Yuquan Zhang Abid Hussain Hong Tan Mengyu Zhang Yongxiang Zhao Yuanyu Huang Xing-Jie Liang 
supported by the Beijing Nova Program from Beijing Municipal Science&Technology Commission(No.Z201100006820005);the Beijing-Tianjin-Hebei Basic Research Cooperation Project(No.19JCZDJC64100);the National Key Research&Development Program of China(Nos.2018YFE0117800,2021YFA1201000,and 2021YFE0106900);the National Natural Science Foundation of China(Nos.32030060 and 31871003);the Natural Science Foundation of China international collaboration key project(No.51861135103).
Attaching DNA/RNA to nanomaterials is the basis for nucleic acid-based assembly and drug delivery.Herein,we report that small interfering RNA(siRNA)effectively coordinates with ligand-free lanthanide nanoparticles(NaG...
关键词：coordination chemistry nuclei acid lanthanide nanomaterials small interfering RNA(siRNA)delivery endosome escape 
The RING E3 ligase CLG1 targets GS3 for degradation via the endosome pathway to determine grain size in rice被引量：9
《Molecular Plant》2021年第10期1699-1713,共15页Wensi Yang Kun Wu Bo Wang Huanhuan Liu Siyi Guo Xiaoyu Guo Wei Luo Shengyuan Sun Yidan Ouyang Xiangdong Fu Kang Chong Qifa Zhang Yunyuan Xu 
This work was supported by grants from the National Key Research and Development Program(2016YFD0100901 and 2016YFD0100903);the Earmarked Fund for the China Agricultural Research System(CARS-01-05).
G-protein signaling and ubiquitin-dependent degradation are both involved in grain development in rice,but how these pathways are coordinated in regulating this process is unknown.Here,we show that Chang Li Geng 1(CLG...
关键词：grain size CLG1 GS3 E3 ligase ENDOSOME 
AAV8 transduction capacity is reduced by prior exposure to endosome-like pH conditions
《Neural Regeneration Research》2021年第5期851-855,共5页Jeffrey ALowell Kar Men Mah John LBixby Vance PLemmon 
This work was supported by grants to JLB and VPL from the National Institutes of Health(NS100531);the Craig H.Neilsen Foundation(598684);the Miami Project to Cure Paralysis.VPL holds the Walter G.Ross Distinguished Chair in Developmental Neuroscience.
Adeno-associated virus(AAV)is an essential instrument in the neuroscientist’s toolkit,which allows delivery of DNA to provide labeling with fluorescent proteins or genetic instructions to regulate gene expression.In ...
关键词：adeno-associated virus autolytic CAPSID low pH PROTEASE PROTEOLYTIC temperature TRAFFICKING TRANSDUCTION viral inactivation 
CDK11 negatively regulates Wnt/β-catenin signaling in the endosomal compartment by affecting microtubule stability被引量：1
《Cancer Biology & Medicine》2020年第2期328-342,共15页Danmin Ou Lin Chen Jiang He Zhuoxian Rong Jie Gao Liyu Liu Feiyu Tang Jiang Li Yuezhen Deng Lunquan Sun 
grants from the National Natural Science Foundation of China(Grant No.81530084,81874200,and 81572750);the Hunan Science and Technology Department(Grant No.2018RS3028);Central South University(Grant No.20170033010007);The Strategy-Orientated Special Project of Central South University(Grant No.ZLXD2017003).
Objectives:Improper activation of Wnt/β-catenin signaling has been implicated in human diseases.Beyond the well-studied glycogen synthase kinase 3p(GSK3p)and casein kinase 1(CK1),other kinases affecting Wnt/β-cateni...
关键词：Wnt/β-catenin signaling CDK11 ENDOSOME MICROTUBULE SIRT2 
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