Stay in touch with the endoplasmic reticulum  

作　　者：Sha Sun Gan Zhao Mingkang Jia Qing Jiang Shulin Li Haibin Wang Wenjing Li Yunyun Wang Xin Bian Yan G.Zhao Xun Huang Ge Yang Huaqing Cai Jose C.Pastor-Pareja Liang Ge Chuanmao Zhang Junjie Hu 

机构地区：[1]National Laboratory of Biomacromolecules,Institute of Biophysics,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Beijing 100101,China [2]The Ministry of Education Key Laboratory of Cell Proliferation and Differentiation,College of Life Sciences,Peking University,Beijing 100871,China [3]State Key Laboratory of Membrane Biology,Tsinghua-Peking Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing 100084,China [4]Laboratory of Computational Biology&Machine Intelligence,School of Artificial Intelligence,University of Chinese Academy of Sciences,Beijing 100049,China [5]State Key Laboratory of Medicinal Chemical Biology,College of Life Sciences,Nankai University,Tianjin 300071,China [6]Brain Research Center,Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen 518055,China [7]State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Innovation Academy for Seed Design,Chinese Academy of Sciences,Beijing 100101,China [8]Institute of Neurosciences,Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández,San Juan de Alicante 03550,Spain

出　　处：《Science China(Life Sciences)》2024年第2期230-257,共28页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(92254305);supported by the National Natural Science Foundation of China(92254305,91854204,32130026);supported by National Natural Science Foundation of China(92254302,32225013,32130023);supported by the National Natural Science Foundation of China(91954201,31971289);supported by grants from the National Natural Science Foundation of China(91954207);supported by the National Natural Science Foundation of China(32170753);supported by the National Natural Science Foundation of China(32170692,92154001);supported by grants from the National Natural Science Foundation of China(92254303,32170701);supported by grants from the National Natural Science Foundation of China(32101000,32271273);the Strategic Priority Research Program(XDB39000000);Project for Young Scientists in Basic Research(YSBR-075)of the Chinese Academy of Sciences;the National Key Research and Development Program of China(2021YFA1300800);National Key Research and Development Program of China(2021YFA0804802,2019YFA0508602);Beijing Natural Science Foundation(JQ20028);New Cornerstone Science Foundation(Xplorer Prize);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37020304);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37040402);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA24030205);the National Key Research and Development Program of China(2021YFA1300301);the National Key Research and Development Program of China(2018YFA0506902);the Fundamental Research Funds for the Central Universities(63213104,63223043);the Talent Training Project at Nankai University(035-BB042112);supported by the Beijing Municipal Science&Technology Commission(5202022)。

摘　　要：The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic cells.As a result,it engages a variety of organelles by establishing membrane contact sites(MCSs).These contacts regulate organelle positioning and remodeling,including fusion and fission,facilitate precise lipid exchange,and couple vital signaling events.Here,we systematically review recent advances and converging themes on ER-involved organellar contact.The molecular basis,cellular influence,and potential physiological functions for ER/nuclear envelope contacts with mitochondria,Golgi,endosomes,lysosomes,lipid droplets,autophagosomes,and plasma membrane are summarized.

关 键 词：endoplasmic reticulum nuclear envelope MITOCHONDRIA Golgi apparatus ENDOSOME LYSOSOME lipid droplets AUTOPHAGOSOME plasma membrane membrane contact site 

分 类 号：Q25[生物学—细胞生物学]