AUTOPHAGOSOME

作品数：45被引量：469H指数：9
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相关领域：医药卫生生物学更多>>
相关作者：金娟何强李一乔龚建光魏富鑫更多>>
相关机构：浙江省人民医院空军军医大学（第四军医大学）中山大学附属第一医院美国德州大学更多>>
相关期刊：《解剖学杂志》《Neuroscience Bulletin》《World Journal of Biological Chemistry》《Yangtze Medicine》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家教育部博士点基金更多>>
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The plant retromer components SNXs bind to ATG8 and CLASP to mediate autophagosome movement along microtubules
《Molecular Plant》2025年第3期416-436,共21页Yanglan Liao Xibao Li Wenlong Ma Xinyi Lin Jiayi Kuang Xuanang Zheng Zien Li Fanfan Qiao Chuanliang Liu Jun Zhou Faqiang Li Ruixi Li Byung-Ho Kang Hongbo Li Caiji Gao 
supported by grants from the National Natural Science Foundation of China(32270291,32061160467,32470797,and 31870171);the Guangdong Province Rural Revitalization Strategy Special Funding for Seed Industry Vitalization to C.G.,the NSFC grant(32000365,32370329);Guangdong Basic and Applied Basic Research Foundation(2021A1515010913,2024B1515020043);H.L.,and the Research Grant Council of Hong Kong(GRF14113921,GRF14109222,GRF14110823,N_CUHK462/22,and C4014-23G)to B.-H.K.
In eukaryotic cells,autophagosomes are double-membrane vesicles that are highly mobile and traffic along cytoskeletal tracks.While core autophagy-related proteins(ATGs)and other regulators involved in autophagosome bi...
关键词：autophagy SNX CLASP MICROTUBULE autophagosome trafficking Arabidopsis thaliana 
Exogenous estrogen partially rescues progesterone deficiency and autophagosome enlargement in Mcoln1^(-/-)mouse model with lysosomal storage disorder
《Reproductive and Developmental Medicine》2024年第4期197-205,共9页Zidao Wang Yuehuan Li Christian L.Andersen Ahmed E.El Zowalaty Jonathan M.Hancock Taylor E.Martin Elizabeth W.Howerth Suvitha Viswanathan Haeyeun Byun Xiaoqin Ye 
the Offfce of the Vice President for Research,Interdisciplinary Toxicology Program,and Department of Physiology and Pharmacology at the University of Georgia,and the National Institutes of Health(grants NIH R01HD065939[co-funded by ORWH and NICHD],R03HD097384,and R03 HD100652 to X.Y.)for ffnancial support;Serum P4 and E2 levels were determined at The University of Virginia Center for Research in Reproduction Ligand Assay and Analysis Core,which is supported by the Eunice Kennedy Shriver NICHD/NIH(NCTRI)Grant P50-HD28934.
Objective:FemaleMcoln1^(-/-)mice exhibit progressive progesterone(P4)deficiency,luteal cell degeneration,and premature embryo implantation failure at 5 months old.We attempted to rescue embryo implantation in non-virg...
关键词：TRPML1/Mcoln1 Corpus luteum PROGESTERONE ESTROGEN Heat shock protein 60 Collagen IV Transmission electron microscopy AUTOPHAGOSOME Lipid droplet 
Ultrasound-activated in situ click chemistry to trigger autophagosome tracking for enhanced autophagy blockade and synergistic cancer therapy
《Aggregate》2024年第4期386-398,共13页Weixi Jiang Jingxue Wang Li Chen Xiaoling Qiu Chier Du Hongjin An Xun Guo Xiaoting Wang Junrui Wang Pan Li Zhigang Wang Haitao Ran Zhiyi Zhou Xiaoyuan Chen Jingjing Zhang Jianli Ren 
China Postdoctoral Science Foundation,Grant/Award Numbers:2022TQ0396,2023MD744153;National Natural Science Foundation of China,Grant/Award Numbers:82302218,82171946;CQMU Program for Youth Innovation in Future Medicine,Grant/Award Number:W0026;Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University,Grant/Award Number:KR2023Y044;Chongqing Science and Health Joint Medical Research Project-Young and Middle-Aged High-Level Talent Project,Grant/Award Number:2020GDRC011。
The blockade of cytoprotective autophagy has been demonstrated to effectively enhance the efficacy of sonodynamic therapy(SDT).However,the limited recognition of antiautophagy agents for autophagosomes impedes the cli...
关键词：autophagosomes tracking autophagy blockade click reaction sonodynamic therapy synergy 
Pyrimethamine upregulates BNIP3 to interfere SNARE-mediated autophagosome-lysosomal fusion in hepatocellular carcinoma被引量：1
《Journal of Pharmaceutical Analysis》2024年第2期211-224,共14页Jingjing Wang Qi Su Kun Chen Qing Wu Jiayan Ren Wenjuan Tang Yu Hu Zeren Zhu Cheng Cheng Kaihui Tu Huaizhen He Yanmin Zhang 
supported by the National Natural Science Foundation of China(Grant No:81903643);the“Young Talent Support Plan”of Xi'an Jiaotong University,the Shaanxi Province Science and Technology Development Plan Project(Grant No.:2022ZDLSF05-05);the Project of Shaanxi Provincial Administration of Traditional Chinese Medicine(Project No.:2021-03-ZZ-002);the Shaanxi Province Science Fund for Distinguished Young Scholars(Grant No:2023-JC-JQ-59).
Hepatocellular carcinoma (HCC) is one of the most common tumor types and remains a major clinical challenge. Increasing evidence has revealed that mitophagy inhibitors can enhance the effect of chemotherapy on HCC. Ho...
关键词：PYRIMETHAMINE BNIP3 SNARE Autophagosome-lysosome fusion Hepatocellular carcinoma Sorafenib 
The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome–lysosome fusion被引量：1
《Cell Research》2024年第2期151-168,共18页Fenglei Jian Shen Wang Rui Tian Yufen Wang Chuangpeng Li Yan Li Shixuan Wang Chao Fang Cong Ma Yueguang Rong 
supported by grants from NSFC (92254302, 91854116, 32170685 and 31771529 to Y.R.);supported by the Fundamental Research Funds for the Central Universities (5003510089 and 2023BR028 to Y.R.).
Autophagosome–lysosome fusion mediated by SNARE complexes is an essential step in autophagy.Two SNAP29-containing SNARE complexes have been extensively studied in starvation-induced bulk autophagy,while the relevant ...
关键词：conditions. complex. domain. 
Stay in touch with the endoplasmic reticulum被引量：2
《Science China(Life Sciences)》2024年第2期230-257,共28页Sha Sun Gan Zhao Mingkang Jia Qing Jiang Shulin Li Haibin Wang Wenjing Li Yunyun Wang Xin Bian Yan G.Zhao Xun Huang Ge Yang Huaqing Cai Jose C.Pastor-Pareja Liang Ge Chuanmao Zhang Junjie Hu 
supported by the National Natural Science Foundation of China(92254305);supported by the National Natural Science Foundation of China(92254305,91854204,32130026);supported by National Natural Science Foundation of China(92254302,32225013,32130023);supported by the National Natural Science Foundation of China(91954201,31971289);supported by grants from the National Natural Science Foundation of China(91954207);supported by the National Natural Science Foundation of China(32170753);supported by the National Natural Science Foundation of China(32170692,92154001);supported by grants from the National Natural Science Foundation of China(92254303,32170701);supported by grants from the National Natural Science Foundation of China(32101000,32271273);the Strategic Priority Research Program(XDB39000000);Project for Young Scientists in Basic Research(YSBR-075)of the Chinese Academy of Sciences;the National Key Research and Development Program of China(2021YFA1300800);National Key Research and Development Program of China(2021YFA0804802,2019YFA0508602);Beijing Natural Science Foundation(JQ20028);New Cornerstone Science Foundation(Xplorer Prize);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37020304);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37040402);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA24030205);the National Key Research and Development Program of China(2021YFA1300301);the National Key Research and Development Program of China(2018YFA0506902);the Fundamental Research Funds for the Central Universities(63213104,63223043);the Talent Training Project at Nankai University(035-BB042112);supported by the Beijing Municipal Science&Technology Commission(5202022)。
The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic cells.As a result,it engages a variety of organelles by est...
关键词：endoplasmic reticulum nuclear envelope MITOCHONDRIA Golgi apparatus ENDOSOME LYSOSOME lipid droplets AUTOPHAGOSOME plasma membrane membrane contact site 
S670,an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid,induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome被引量：1
《Acta Pharmacologica Sinica》2024年第1期209-222,共14页Yi-hui Yang Wan Li Li-wen Ren Hong Yang Yi-zhi Zhang Sen Zhang Yue Hao Dong-ke Yu Rong-sheng Tong Guan-hua Du Jian-you Shi Jin-hua Wang 
supported by Bejing Natural Science Foundation(7212157);supported by CAMS Innovation Fund for Medical Sciences(2021-12M-1-029 and 2022-12M-JB-011);National Natural Science Foundation of China(81703536,82073311);Natural Science Foundation of Sichuan Province(2022JDTD0025).
Glioblastoma(GBM)is the most common malignant tumor in the brain with temozolomide(TMZ)as the only approved chemotherapy agent.GBM is characterized by susceptibility to radiation and chemotherapy resistance and recurr...
关键词：GLIOBLASTOMA 3-O-acetyl-11-keto-β-boswellic acid S670 ferroptosis fusion of autophagosome and lysosome STX17 
Porphyromonas gingivalis,a periodontal pathogen,impairs post-infarcted myocardium by inhibiting autophagosome–lysosome fusion被引量：2
《International Journal of Oral Science》2023年第4期626-639,共14页Yuka Shiheido-Watanabe Yasuhiro Maejima Shun Nakagama Qintao Fan Natsuko Tamura Tetsuo Sasano 
supported by Japan Society for the Promotion of Science (JSPS) KAKENHI Grant-in-Aid for Scientific Research (C) 20K08399 (to Yasuhiro Maejima);KAKENHI 19K18985,Grant-in-Aid for JSPS Fellows;MSD Life Science Foundation;Public Interest Incorporated Foundation (to Yuka Shiheido-Watanabe)
While several previous studies have indicated the link between periodontal disease (PD) and myocardial infarction (MI), theunderlying mechanisms remain unclear. Autophagy, a cellular quality control process that is ac...
关键词：INHIBITING MYOCARDIUM PERIODONTAL 
Reconstitution of membrane contact by unilamellar vesicles
《Biophysics Reports》2023年第4期188-194,共7页Shulin Li Min Zhang Liang Ge 
funded by National Natural Science Foundation of China(32225013,32130023,9225430003,31872832);Ministry of Science and Technology of the People’s Republic of China(2021YFA0804802,2019YFA0508602);Beijing Natural Science Foundation(JQ20028);supported by Vanke Special Fund for Public Health and Health Discipline Development,Tsinghua University(2022Z82WKJ009)
Eukaryotic cells compartmentalize diverse biochemical functions within organelles defined by intracellular membranes.Recent focus has intensified on studying the interactions among organelles and the role of membrane ...
关键词：Membrane contacts Organelle interaction network Giant unilamellar vesicle(GUV) Liposome ER-Golgi intermediate compartment(ERGIC) ER-exit sites(ERES) COPII TMED9 SEC12 Autophagy AUTOPHAGOSOME 
Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer被引量：3
《Cancer Communications》2023年第5期582-612,共31页Yan Guo Yuqing Cui Yangyang Li Xiaoying Jin Dandan Wang Mengxia Lei Fengzhi Chen Yali Liu Jinwen Xu Guanyu Yao Guangchun Zeng Xuesong Chen 
National Natural Science Foundation of China,Grant/Award Numbers:81573001,81773295;Haiyan Research Fund Project of Harbin Medical University Cancer Hospital,Grant/Award Number:JJZD2023-04;Beijing Kechuang Medical Development Foundation,Grant/Award Number:KC2021-JF-0055-06。
Background:Nuclear Yes1-associated transcriptional regulator(YAP1)promotes tumor progression.However,the function of cytoplasmic YAP1 in breast cancer cells and its impact on the survival of breast cancer patients rem...
关键词：Autophagosome closure Autophagy Breast cancer CHMP2B Cytoplasmic YAP1 EGCG ESCRT-III Hippo pathway NEDD4L UBIQUITIN VPS4B 
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