supported by the National Institutes of Health-Office of Research Infrastructure Programs(P40 OD010440);supported in part by grants from the National Cancer Center of Korea(NCC-2110160,NCC-2110263,and NCC-2310750);supported by the Basic Science Research Program of the National Research Foundation of Korea,funded by the Ministry of Science,ICT,and Future Planning(NRF-2015R1C1A1A01053611).
The growth of Caenorhabditis elegans involves multiple molting processes,during which old cuticles are shed and new cuticles are rapidly formed.This process requires the regulated bulk secretion of cuticle components....
funded by National Natural Science Foundation of China(32225013,32130023,9225430003,31872832);Ministry of Science and Technology of the People’s Republic of China(2021YFA0804802,2019YFA0508602);Beijing Natural Science Foundation(JQ20028);supported by Vanke Special Fund for Public Health and Health Discipline Development,Tsinghua University(2022Z82WKJ009)
Eukaryotic cells compartmentalize diverse biochemical functions within organelles defined by intracellular membranes.Recent focus has intensified on studying the interactions among organelles and the role of membrane ...
funded by Beijing Natural Science Foundation(JQ20028);the National Natural Science Foundation of China(32130023,91854114,32061143009);Ministry of Science and Technology of the People’s Republic of China(2019YFA0508602,2021YFA0804802)。
Introduction Macroautophagy(hereafter referred as autophagy)is a process of cellular self-degradation.In response to nutrient deprivation or other stimuli,a nascent double-membrane autophagosome,encapsulating intracel...
supported by grants from the National Natural Science Foundation of China(91854118,31921002,31730108,32061143026);the major projects of the Ministry of Science and Technology(2021ZD0202300);Chinese Academy of Sciences(XDB32020100,YJKYYQ20200052)。
Coat protein complex Ⅱ(COPⅡ)-coated vesicles are responsible for transporting the cargoes from the endoplasmic reticulum(ER) to different destinations. c TAGE5/MEA6 is essential for the development and function of d...
This work was supported by POR FERS Regione Campania 2014–2020 ASSE 1 O.S 1.2;grant System Innovation for Cancer Early Diagnosis(SICED).
The endoplasmic reticulum(ER)is the site of entry of all proteins that function in the secretory pathway including the extracellular environment.Because it controls the folding of newly synthesized secretory proteins,...
the Ministry of Science and Technology of China(2017YFA0503404 and 2016YFA0500202);L.Y.,the National Natural Science Foundation of China(31790401);the Natural Science Foundation of China international cooperation and exchange program(31561143002);the Independent Research of Tsinghua University(20161080135)to L.Y.
Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorl...
the grants from the Scientific Research Project of Education Department of Hunan Province,China(Nos.18C1748 and 19B578).
Endoplasmic reticulum(ER)-associated degradation(ERAD)plays an essential role in protein quality control in the ER.It acts through recognizing misfolded or unassembled proteins and retrotranslocating them across the E...
Lipid accumulation, which may be caused by the disturbance in very low density lipoprotein (VLDL) secretion in the liver, can lead to fatty liver disease. VLDL is synthesized in endoplasmic reticulum (ER) and tran...