COPII

作品数:10被引量:12H指数:2
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相关领域:生物学农业科学更多>>
相关作者:徐晓峰莫蓓莘严建兵李慧余小彬更多>>
相关机构:深圳大学北京大学华中农业大学中国科学院大学更多>>
相关期刊:《生命科学》《Acta Biochimica et Biophysica Sinica》《Biophysics Reports》《生理学报》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划北京市自然科学基金更多>>
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TMEM39A and TMEM131 facilitate bulk transport of ECM proteins through large COPII vesicle formation
《Journal of Genetics and Genomics》2025年第2期189-203,共15页Jee Young Sung Ga-Eun Lim Jarim Goo Kyung Jin Jung Jeong Min Chung Hyun Suk Jung Yong-Nyun Kim Jaegal Shim 
supported by the National Institutes of Health-Office of Research Infrastructure Programs(P40 OD010440);supported in part by grants from the National Cancer Center of Korea(NCC-2110160,NCC-2110263,and NCC-2310750);supported by the Basic Science Research Program of the National Research Foundation of Korea,funded by the Ministry of Science,ICT,and Future Planning(NRF-2015R1C1A1A01053611).
The growth of Caenorhabditis elegans involves multiple molting processes,during which old cuticles are shed and new cuticles are rapidly formed.This process requires the regulated bulk secretion of cuticle components....
关键词:Bulk secretion COLLAGEN COPII ECM TMEM39A TMEM131 
Reconstitution of membrane contact by unilamellar vesicles
《Biophysics Reports》2023年第4期188-194,共7页Shulin Li Min Zhang Liang Ge 
funded by National Natural Science Foundation of China(32225013,32130023,9225430003,31872832);Ministry of Science and Technology of the People’s Republic of China(2021YFA0804802,2019YFA0508602);Beijing Natural Science Foundation(JQ20028);supported by Vanke Special Fund for Public Health and Health Discipline Development,Tsinghua University(2022Z82WKJ009)
Eukaryotic cells compartmentalize diverse biochemical functions within organelles defined by intracellular membranes.Recent focus has intensified on studying the interactions among organelles and the role of membrane ...
关键词:Membrane contacts Organelle interaction network Giant unilamellar vesicle(GUV) Liposome ER-Golgi intermediate compartment(ERGIC) ER-exit sites(ERES) COPII TMED9 SEC12 Autophagy AUTOPHAGOSOME 
Biogenesis of autophagosomes from the ERGIC membrane system被引量:1
《Journal of Genetics and Genomics》2023年第1期3-6,共4页Yaping Han Shulin Li Liang Ge 
funded by Beijing Natural Science Foundation(JQ20028);the National Natural Science Foundation of China(32130023,91854114,32061143009);Ministry of Science and Technology of the People’s Republic of China(2019YFA0508602,2021YFA0804802)。
Introduction Macroautophagy(hereafter referred as autophagy)is a process of cellular self-degradation.In response to nutrient deprivation or other stimuli,a nascent double-membrane autophagosome,encapsulating intracel...
关键词:ERGIC COPII vesicle Autophagosome biogenesis Autophagy ERES 
Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions被引量:1
《Journal of Genetics and Genomics》2022年第6期519-522,共4页Tiantian Ma Feng Zhang Yaqing Wang Zhiheng Xu 
supported by grants from the National Natural Science Foundation of China(91854118,31921002,31730108,32061143026);the major projects of the Ministry of Science and Technology(2021ZD0202300);Chinese Academy of Sciences(XDB32020100,YJKYYQ20200052)。
Coat protein complex Ⅱ(COPⅡ)-coated vesicles are responsible for transporting the cargoes from the endoplasmic reticulum(ER) to different destinations. c TAGE5/MEA6 is essential for the development and function of d...
关键词:cTAGE5/MEA6 COPII ER Cargo secretion 
ER exit pathways and the control of proteostasis:Crucial role of the UPR,COPII,and ER-phagy in the secretory pathway
《BIOCELL》2022年第5期1131-1137,共7页GIUSEPPINA AMODIO VALENTINA PAGLIARA PAOLO REMONDELLI ORNELLA MOLTEDO 
This work was supported by POR FERS Regione Campania 2014–2020 ASSE 1 O.S 1.2;grant System Innovation for Cancer Early Diagnosis(SICED).
The endoplasmic reticulum(ER)is the site of entry of all proteins that function in the secretory pathway including the extracellular environment.Because it controls the folding of newly synthesized secretory proteins,...
关键词:PROTEOSTASIS ER stress Unfolded protein response COPII ER-phagy 
COPII mitigates ER stress by promoting formation of ER whorls被引量:5
《Cell Research》2021年第2期141-156,共16页Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu 
the Ministry of Science and Technology of China(2017YFA0503404 and 2016YFA0500202);L.Y.,the National Natural Science Foundation of China(31790401);the Natural Science Foundation of China international cooperation and exchange program(31561143002);the Independent Research of Tsinghua University(20161080135)to L.Y.
Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorl...
关键词:STRESS ). environment. 
A COPII subunit interacting with ER-phagy receptor:a new potential avenue to maintaining neuronal homeostasis被引量:1
《Acta Biochimica et Biophysica Sinica》2020年第6期698-700,共3页Shifang Huang Mingzhu Tang Honglu Jiang Yuting Li Haoliang Hu 
the grants from the Scientific Research Project of Education Department of Hunan Province,China(Nos.18C1748 and 19B578).
Endoplasmic reticulum(ER)-associated degradation(ERAD)plays an essential role in protein quality control in the ER.It acts through recognizing misfolded or unassembled proteins and retrotranslocating them across the E...
关键词:HOMEOSTASIS shaped POTENTIAL 
Mea6 controls VLDL transport through the coordinated regulation of COPil assembly被引量:5
《Cell Research》2016年第7期787-804,共18页Yaqing Wang Liang Liu Hongsheng Zhang Junwan Fan FengZhang Mei Yu Lei Shi Lin Yang Sin Man Lam Huimin Wang Xiaowei Chen Yingchun Wang Fei Gao Guanghou Shui Zhiheng Xu 
Lipid accumulation, which may be caused by the disturbance in very low density lipoprotein (VLDL) secretion in the liver, can lead to fatty liver disease. VLDL is synthesized in endoplasmic reticulum (ER) and tran...
关键词:Mea6 fatty liver lipid transport and VLDL secretion COPII machinery 
COPII各组分在蛋白质分泌途径中的功能被引量:1
《生命科学》2016年第4期442-451,共10页徐晓峰 普雪娇 莫蓓莘 
国家自然科学基金项目(31571332)
细胞质被膜复合体II(COPII)介导蛋白质从内质网(ER)运向高尔基体(Golgi)。它是真核生物蛋白质分泌途径中的重要组分,在保持细胞内各个细胞器动态平衡中发挥重要功能。COPII小泡由5种高度保守的细胞质蛋白组成:胞质GTP酶Ras相关蛋白1(Sa...
关键词:COPII 蛋白质分泌途径 亚单位 冗余 
转运蛋白颗粒复合体在囊泡拴系中的作用与相关疾病(英文)
《生理学报》2014年第1期1-6,共6页李春满 余小彬 
在真核细胞中,囊泡介导的蛋白质转运是一个高度可控的多步骤过程。在囊泡与靶细胞器膜成分融合之前,许多因子参与了它们之间的特异性识别和拴系。其中大部分由多亚基复合体或卷曲螺旋蛋白构成的拴系因子,在小G蛋白的协助下,介导了囊泡...
关键词:转运蛋白颗粒复合体 囊泡 COPII衣被蛋白 精神发育迟滞 肢带型肌营养不良症 
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